Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent

Christopher Hübel; Héléna A Gaspar; Jonathan R I Coleman; Ken B Hanscombe; Kirstin Purves; Inga Prokopenko; Mariaelisa Graff; Julius S Ngwa; Tsegaselassie Workalemahu; Paul F O'Reilly; Cynthia M Bulik; Gerome Breen; ADHD Working Group of the Psychiatric Genomics Consortium; Eating Disorders Working Group of the Psychiatric Genomics Consortium

doi:10.1038/s41467-019-13544-0

Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent

Christopher Hübel
, Héléna A Gaspar
, Jonathan R I Coleman
, Ken B Hanscombe
, Kirstin Purves
, Inga Prokopenko
, Mariaelisa Graff
, Julius S Ngwa
, Tsegaselassie Workalemahu
, Paul F O'Reilly
, Cynthia M Bulik
, Gerome Breen
, ADHD Working Group of the Psychiatric Genomics Consortium
, Eating Disorders Working Group of the Psychiatric Genomics Consortium

King's College London
University of Surrey
University of North Carolina at Charlotte
Johns Hopkins Bloomberg School of Public Health
National Institutes of Health
Karolinska Institutet

Research output: Contribution to journal › Article › peer-review

76 Citations (Scopus)

10 Downloads (Pure)

Abstract

Body composition is often altered in psychiatric disorders. Using genome-wide common genetic variation data, we calculate sex-specific genetic correlations amongst body fat %, fat mass, fat-free mass, physical activity, glycemic traits and 17 psychiatric traits (up to N = 217,568). Two patterns emerge: (1) anorexia nervosa, schizophrenia, obsessive-compulsive disorder, and education years are negatively genetically correlated with body fat % and fat-free mass, whereas (2) attention-deficit/hyperactivity disorder (ADHD), alcohol dependence, insomnia, and heavy smoking are positively correlated. Anorexia nervosa shows a stronger genetic correlation with body fat % in females, whereas education years is more strongly correlated with fat mass in males. Education years and ADHD show genetic overlap with childhood obesity. Mendelian randomization identifies schizophrenia, anorexia nervosa, and higher education as causal for decreased fat mass, with higher body fat % possibly being a causal risk factor for ADHD and heavy smoking. These results suggest new possibilities for targeted preventive strategies.

Original language	English
Pages (from-to)	5765
Number of pages	12
Journal	Nature Communications
Volume	10
Issue number	1
Early online date	18 Dec 2019
DOIs	https://doi.org/10.1038/s41467-019-13544-0
Publication status	Published - 18 Dec 2019

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Age Factors
Blood Glucose/genetics
Body Composition/genetics
Comorbidity
Educational Status
Female
Genetic Variation
Genome-Wide Association Study
Humans
Male
Mental Disorders/epidemiology
Middle Aged
Multifactorial Inheritance/genetics
Overweight/epidemiology
Phenotype
Physical Fitness
Risk Factors
Sex Factors

Access to Document

10.1038/s41467-019-13544-0Licence: CC BY

Hubel_etal_NC_Genetic_Correlations_Of_VoR
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Final published version, 862 KBLicence: CC BY

Cite this

Hübel, C., Gaspar, H. A., Coleman, J. R. I., Hanscombe, K. B., Purves, K., Prokopenko, I., Graff, M., Ngwa, J. S., Workalemahu, T., O'Reilly, P. F., Bulik, C. M., Breen, G., ADHD Working Group of the Psychiatric Genomics Consortium, & Eating Disorders Working Group of the Psychiatric Genomics Consortium (2019). Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent. Nature Communications, 10(1), 5765. https://doi.org/10.1038/s41467-019-13544-0

Hübel, C, Gaspar, HA, Coleman, JRI, Hanscombe, KB, Purves, K, Prokopenko, I, Graff, M, Ngwa, JS, Workalemahu, T, O'Reilly, PF, Bulik, CM, Breen, G, ADHD Working Group of the Psychiatric Genomics Consortium & Eating Disorders Working Group of the Psychiatric Genomics Consortium 2019, 'Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent', Nature Communications, vol. 10, no. 1, pp. 5765. https://doi.org/10.1038/s41467-019-13544-0

@article{11c2afc8869c4d378182563f1fd010b9,

title = "Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent",

abstract = "Body composition is often altered in psychiatric disorders. Using genome-wide common genetic variation data, we calculate sex-specific genetic correlations amongst body fat \%, fat mass, fat-free mass, physical activity, glycemic traits and 17 psychiatric traits (up to N = 217,568). Two patterns emerge: (1) anorexia nervosa, schizophrenia, obsessive-compulsive disorder, and education years are negatively genetically correlated with body fat \% and fat-free mass, whereas (2) attention-deficit/hyperactivity disorder (ADHD), alcohol dependence, insomnia, and heavy smoking are positively correlated. Anorexia nervosa shows a stronger genetic correlation with body fat \% in females, whereas education years is more strongly correlated with fat mass in males. Education years and ADHD show genetic overlap with childhood obesity. Mendelian randomization identifies schizophrenia, anorexia nervosa, and higher education as causal for decreased fat mass, with higher body fat \% possibly being a causal risk factor for ADHD and heavy smoking. These results suggest new possibilities for targeted preventive strategies.",

keywords = "Age Factors, Blood Glucose/genetics, Body Composition/genetics, Comorbidity, Educational Status, Female, Genetic Variation, Genome-Wide Association Study, Humans, Male, Mental Disorders/epidemiology, Middle Aged, Multifactorial Inheritance/genetics, Overweight/epidemiology, Phenotype, Physical Fitness, Risk Factors, Sex Factors",

author = "Christopher H{\"u}bel and Gaspar, \{H{\'e}l{\'e}na A\} and Coleman, \{Jonathan R I\} and Hanscombe, \{Ken B\} and Kirstin Purves and Inga Prokopenko and Mariaelisa Graff and Ngwa, \{Julius S\} and Tsegaselassie Workalemahu and O'Reilly, \{Paul F\} and Bulik, \{Cynthia M\} and Gerome Breen and \{ADHD Working Group of the Psychiatric Genomics Consortium\} and \{Eating Disorders Working Group of the Psychiatric Genomics Consortium\} and Kirsty Kiezebrink",

year = "2019",

month = dec,

day = "18",

doi = "10.1038/s41467-019-13544-0",

language = "English",

volume = "10",

pages = "5765",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Research",

number = "1",

}

TY - JOUR

T1 - Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent

AU - Hübel, Christopher

AU - Gaspar, Héléna A

AU - Coleman, Jonathan R I

AU - Hanscombe, Ken B

AU - Purves, Kirstin

AU - Prokopenko, Inga

AU - Graff, Mariaelisa

AU - Ngwa, Julius S

AU - Workalemahu, Tsegaselassie

AU - O'Reilly, Paul F

AU - Bulik, Cynthia M

AU - Breen, Gerome

AU - ADHD Working Group of the Psychiatric Genomics Consortium

AU - Eating Disorders Working Group of the Psychiatric Genomics Consortium

AU - Kiezebrink, Kirsty

PY - 2019/12/18

Y1 - 2019/12/18

N2 - Body composition is often altered in psychiatric disorders. Using genome-wide common genetic variation data, we calculate sex-specific genetic correlations amongst body fat %, fat mass, fat-free mass, physical activity, glycemic traits and 17 psychiatric traits (up to N = 217,568). Two patterns emerge: (1) anorexia nervosa, schizophrenia, obsessive-compulsive disorder, and education years are negatively genetically correlated with body fat % and fat-free mass, whereas (2) attention-deficit/hyperactivity disorder (ADHD), alcohol dependence, insomnia, and heavy smoking are positively correlated. Anorexia nervosa shows a stronger genetic correlation with body fat % in females, whereas education years is more strongly correlated with fat mass in males. Education years and ADHD show genetic overlap with childhood obesity. Mendelian randomization identifies schizophrenia, anorexia nervosa, and higher education as causal for decreased fat mass, with higher body fat % possibly being a causal risk factor for ADHD and heavy smoking. These results suggest new possibilities for targeted preventive strategies.

AB - Body composition is often altered in psychiatric disorders. Using genome-wide common genetic variation data, we calculate sex-specific genetic correlations amongst body fat %, fat mass, fat-free mass, physical activity, glycemic traits and 17 psychiatric traits (up to N = 217,568). Two patterns emerge: (1) anorexia nervosa, schizophrenia, obsessive-compulsive disorder, and education years are negatively genetically correlated with body fat % and fat-free mass, whereas (2) attention-deficit/hyperactivity disorder (ADHD), alcohol dependence, insomnia, and heavy smoking are positively correlated. Anorexia nervosa shows a stronger genetic correlation with body fat % in females, whereas education years is more strongly correlated with fat mass in males. Education years and ADHD show genetic overlap with childhood obesity. Mendelian randomization identifies schizophrenia, anorexia nervosa, and higher education as causal for decreased fat mass, with higher body fat % possibly being a causal risk factor for ADHD and heavy smoking. These results suggest new possibilities for targeted preventive strategies.

KW - Age Factors

KW - Blood Glucose/genetics

KW - Body Composition/genetics

KW - Comorbidity

KW - Educational Status

KW - Female

KW - Genetic Variation

KW - Genome-Wide Association Study

KW - Humans

KW - Male

KW - Mental Disorders/epidemiology

KW - Middle Aged

KW - Multifactorial Inheritance/genetics

KW - Overweight/epidemiology

KW - Phenotype

KW - Physical Fitness

KW - Risk Factors

KW - Sex Factors

U2 - 10.1038/s41467-019-13544-0

DO - 10.1038/s41467-019-13544-0

M3 - Article

C2 - 31852892

SN - 2041-1723

VL - 10

SP - 5765

JO - Nature Communications

JF - Nature Communications

IS - 1

ER -

Genetic correlations of psychiatric traits with body composition and glycemic traits are sex- and age-dependent

Abstract

UN SDGs

Keywords

Access to Document

Fingerprint

Cite this