Genome stability and the processing of damaged replication forks by RecG

Peter McGlynn; R. G. Lloyd

doi:10.1016/S0168-9525(02)02720-8

Genome stability and the processing of damaged replication forks by RecG

Peter McGlynn, R. G. Lloyd

Medical Sciences

Research output: Contribution to journal › Editorial › peer-review

123 Citations (Scopus)

Abstract

Chromosomal duplication faces many blocks to replication fork progression that could destabilize the genome and prove fatal if not overcome. Overcoming such blocks requires interplay between DNA replication, recombination and repair. The Recta protein of Escherichia coli promotes rescue of damaged forks by catalysing their unwinding and conversion to Holliday junctions. Subsequent processing of this structure allows repair or bypass of the fork block, enabling replication to resume without recourse to potentially mutagenic translesion synthesis or recombination. Such direct rescue of stalled forks might help safeguard genome integrity in all organisms.

Original language	English
Pages (from-to)	413-419
Number of pages	6
Journal	Trends in Genetics
Volume	18
Issue number	8
DOIs	https://doi.org/10.1016/S0168-9525(02)02720-8
Publication status	Published - 2002

Keywords

ESCHERICHIA-COLI K-12
BRANCH MIGRATION PROTEIN
STABLE DNA-REPLICATION
LAGGING-STRAND
HOLLIDAY JUNCTIONS
R-LOOPS
RECOMBINATION
RUVABC
REPAIR
PRIA

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title = "Genome stability and the processing of damaged replication forks by RecG",

abstract = "Chromosomal duplication faces many blocks to replication fork progression that could destabilize the genome and prove fatal if not overcome. Overcoming such blocks requires interplay between DNA replication, recombination and repair. The Recta protein of Escherichia coli promotes rescue of damaged forks by catalysing their unwinding and conversion to Holliday junctions. Subsequent processing of this structure allows repair or bypass of the fork block, enabling replication to resume without recourse to potentially mutagenic translesion synthesis or recombination. Such direct rescue of stalled forks might help safeguard genome integrity in all organisms.",

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TY - JOUR

T1 - Genome stability and the processing of damaged replication forks by RecG

AU - McGlynn, Peter

AU - Lloyd, R. G.

PY - 2002

Y1 - 2002

N2 - Chromosomal duplication faces many blocks to replication fork progression that could destabilize the genome and prove fatal if not overcome. Overcoming such blocks requires interplay between DNA replication, recombination and repair. The Recta protein of Escherichia coli promotes rescue of damaged forks by catalysing their unwinding and conversion to Holliday junctions. Subsequent processing of this structure allows repair or bypass of the fork block, enabling replication to resume without recourse to potentially mutagenic translesion synthesis or recombination. Such direct rescue of stalled forks might help safeguard genome integrity in all organisms.

AB - Chromosomal duplication faces many blocks to replication fork progression that could destabilize the genome and prove fatal if not overcome. Overcoming such blocks requires interplay between DNA replication, recombination and repair. The Recta protein of Escherichia coli promotes rescue of damaged forks by catalysing their unwinding and conversion to Holliday junctions. Subsequent processing of this structure allows repair or bypass of the fork block, enabling replication to resume without recourse to potentially mutagenic translesion synthesis or recombination. Such direct rescue of stalled forks might help safeguard genome integrity in all organisms.

KW - ESCHERICHIA-COLI K-12

KW - BRANCH MIGRATION PROTEIN

KW - STABLE DNA-REPLICATION

KW - LAGGING-STRAND

KW - HOLLIDAY JUNCTIONS

KW - R-LOOPS

KW - RECOMBINATION

KW - RUVABC

KW - REPAIR

KW - PRIA

U2 - 10.1016/S0168-9525(02)02720-8

DO - 10.1016/S0168-9525(02)02720-8

M3 - Editorial

SN - 0168-9525

VL - 18

SP - 413

EP - 419

JO - Trends in Genetics

JF - Trends in Genetics

IS - 8

ER -

Genome stability and the processing of damaged replication forks by RecG

Abstract

Keywords

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