Greasing the path to BAX/BAK activation

Emilie Hollville; Seamus J. Martin

doi:10.1016/j.cell.2012.02.006

Greasing the path to BAX/BAK activation

Emilie Hollville
, Seamus J. Martin^*

^*Corresponding author for this work

Medical Sciences

Research output: Contribution to journal › Short survey › peer-review

5 Citations (Scopus)

Abstract

BAX/BAK activation leading to mitochondrial outer-membrane permeabilization is a key commitment point in apoptosis. Chipuk et al. now identify two sphingolipids as specific cofactors for BAX/BAK activation that lower the threshold for apoptosis-associated cytochrome c release. Association of mitochondria with other cellular membrane compartments is required for BAK/BAX exposure to these sphingolipids.

Original language	English
Pages (from-to)	845-846
Number of pages	2
Journal	Cell
Volume	148
Issue number	5
DOIs	https://doi.org/10.1016/j.cell.2012.02.006
Publication status	Published - 2 Mar 2012

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10.1016/j.cell.2012.02.006

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@article{accacb554bba473bad823f9f27ea81eb,

title = "Greasing the path to BAX/BAK activation",

abstract = "BAX/BAK activation leading to mitochondrial outer-membrane permeabilization is a key commitment point in apoptosis. Chipuk et al. now identify two sphingolipids as specific cofactors for BAX/BAK activation that lower the threshold for apoptosis-associated cytochrome c release. Association of mitochondria with other cellular membrane compartments is required for BAK/BAX exposure to these sphingolipids.",

author = "Emilie Hollville and Martin, \{Seamus J.\}",

year = "2012",

month = mar,

day = "2",

doi = "10.1016/j.cell.2012.02.006",

language = "English",

volume = "148",

pages = "845--846",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier BV",

number = "5",

}

TY - JOUR

T1 - Greasing the path to BAX/BAK activation

AU - Hollville, Emilie

AU - Martin, Seamus J.

PY - 2012/3/2

Y1 - 2012/3/2

N2 - BAX/BAK activation leading to mitochondrial outer-membrane permeabilization is a key commitment point in apoptosis. Chipuk et al. now identify two sphingolipids as specific cofactors for BAX/BAK activation that lower the threshold for apoptosis-associated cytochrome c release. Association of mitochondria with other cellular membrane compartments is required for BAK/BAX exposure to these sphingolipids.

AB - BAX/BAK activation leading to mitochondrial outer-membrane permeabilization is a key commitment point in apoptosis. Chipuk et al. now identify two sphingolipids as specific cofactors for BAX/BAK activation that lower the threshold for apoptosis-associated cytochrome c release. Association of mitochondria with other cellular membrane compartments is required for BAK/BAX exposure to these sphingolipids.

UR - https://www.scopus.com/pages/publications/84857870690

U2 - 10.1016/j.cell.2012.02.006

DO - 10.1016/j.cell.2012.02.006

M3 - Short survey

AN - SCOPUS:84857870690

SN - 0092-8674

VL - 148

SP - 845

EP - 846

JO - Cell

JF - Cell

IS - 5

ER -

Greasing the path to BAX/BAK activation

Abstract

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