Growth hormone in the critically ill

Nigel R. Webster*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


Negative nitrogen balance is common in critically ill patients with prolonged intensive care unit stay. Growth hormone supplementation associated with adequate nutritional support in other patient groups resulted in preserved nitrogen balance. Despite the initial promising results of small trials, the large multicenter randomized controlled trial by Takala and colleagues showed that supranormal growth hormone supplementation in critically ill patients increased mortality and morbidity. Therefore, the use of growth hormone in intensive care unit in adult patients who are not known to be severely deficient is still considered inappropriate.

Original languageEnglish
Title of host publicationReducing Mortality in Critically Ill Patients
EditorsGiovanni Landoni, Marta Mucchetti, Alberto Zangrillo, Rinaldo Bellomo
PublisherSpringer International Publishing
Number of pages4
ISBN (Print)9783319175157, 9783319175140
Publication statusPublished - 2015


  • Critically ill
  • Growth hormone
  • Mortality


Dive into the research topics of 'Growth hormone in the critically ill'. Together they form a unique fingerprint.

Cite this