Haematological and Clinical Parameters in Assessing Activity in Hodgkin's Disease and Other Malignant Lymphornas

A. V. Simmons, A. S.D. Spiers, Peter Fayers

Research output: Contribution to journalArticlepeer-review

Abstract

The neutrophil alkaline phosphatase (NAP) levels have been studied in 135 patients with malignant lymphomas on 363 occasions. Elevated NAP levels are relatively common in active Hodgkin's disease and uncommon in other lymphomas. In Hodgkin's disease, activity of the neoplastic process is correlated with elevated NAP scores, but the test has no apparent advantage over estimation of the ESR. Serial estimation of both NAP and ESR may provide a useful index of the recurrence of Hodgkin's disease in the treated patient.
Original languageEnglish
Pages (from-to)111-124
Number of pages14
JournalQJM
Volume42
Issue number1
DOIs
Publication statusPublished - 1 Jan 1973

Bibliographical note

ACKNOWLEDGEMENTS
We are grateful to Professor T. A. J. Prankerd, Professor Sir Richard Doll, and
Professor D. R. Laurence for help and advice in the design and carrying out of this
project. Professor Prankerd, Dr. J. N. Godlee, and Dr. E. W. Emery kindly permitted
us to study patients under their care. We thank the technical staff of the
Haematology Department, University College Hospital, for their help in carrying
out the white blood cell counts and ESR determinations. During part of this
investigation A. S. D. S. was in receipt of a Fellowship from the Nuffield Foundation.

Keywords

  • alkaline phosphatase
  • Hodgkin's disease
  • lymphoma
  • neoplastic processes
  • neutrophils

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