Hederacine A and Hederacine B from Glechoma hederaceae 
Inhibit the growth of Colorectal Cancer Cells in vitro

Y. Kumarasamy; L. Nahar; P. Kong-Thu-Lin; Marcel Jaspars; S. D. Sarker

Hederacine A and Hederacine B from Glechoma hederaceae Inhibit the growth of Colorectal Cancer Cells in vitro

Y. Kumarasamy
, L. Nahar
, P. Kong-Thu-Lin
, Marcel Jaspars
, S. D. Sarker

Chemistry

Research output: Contribution to journal › Article › peer-review

18 Citations (Web of Science)

Abstract

The cytotoxic activity of the tropane alkaloids, hederacine A (1) and hederacine B (2), previously isolated from the methanol extract of the aerial parts of Glechoma hederaceae, was assessed by the MTT cytotoxicity assay using colon cancer cell line (CaCo-2). The IC50 values for 1 and 2 were found to be 86.6 and 301.0 mu M, respectively.

Original language	English
Pages (from-to)	33-35
Number of pages	2
Journal	Natural Product Communications
Volume	1
Issue number	1
Publication status	Published - 2006

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

glechoma hederaceae
Lamiaceae
hederacine A
hederacine 13
tropane alkaloid
colon cancer
MTT
STRUCTURE ELUCIDATION
MULTIDRUG-RESISTANCE

Cite this

@article{1b3297be9cb7457a96031855b2707b79,

title = "Hederacine A and Hederacine B from Glechoma hederaceae Inhibit the growth of Colorectal Cancer Cells in vitro",

abstract = "The cytotoxic activity of the tropane alkaloids, hederacine A (1) and hederacine B (2), previously isolated from the methanol extract of the aerial parts of Glechoma hederaceae, was assessed by the MTT cytotoxicity assay using colon cancer cell line (CaCo-2). The IC50 values for 1 and 2 were found to be 86.6 and 301.0 mu M, respectively.",

keywords = "glechoma hederaceae, Lamiaceae, hederacine A, hederacine 13, tropane alkaloid, colon cancer, MTT, STRUCTURE ELUCIDATION, MULTIDRUG-RESISTANCE",

author = "Y. Kumarasamy and L. Nahar and P. Kong-Thu-Lin and Marcel Jaspars and Sarker, \{S. D.\}",

year = "2006",

language = "English",

volume = "1",

pages = "33--35",

journal = "Natural Product Communications",

issn = "1934-578X",

publisher = "SAGE Publications Inc.",

number = "1",

}

TY - JOUR

T1 - Hederacine A and Hederacine B from Glechoma hederaceae Inhibit the growth of Colorectal Cancer Cells in vitro

AU - Kumarasamy, Y.

AU - Nahar, L.

AU - Kong-Thu-Lin, P.

AU - Jaspars, Marcel

AU - Sarker, S. D.

PY - 2006

Y1 - 2006

N2 - The cytotoxic activity of the tropane alkaloids, hederacine A (1) and hederacine B (2), previously isolated from the methanol extract of the aerial parts of Glechoma hederaceae, was assessed by the MTT cytotoxicity assay using colon cancer cell line (CaCo-2). The IC50 values for 1 and 2 were found to be 86.6 and 301.0 mu M, respectively.

AB - The cytotoxic activity of the tropane alkaloids, hederacine A (1) and hederacine B (2), previously isolated from the methanol extract of the aerial parts of Glechoma hederaceae, was assessed by the MTT cytotoxicity assay using colon cancer cell line (CaCo-2). The IC50 values for 1 and 2 were found to be 86.6 and 301.0 mu M, respectively.

KW - glechoma hederaceae

KW - Lamiaceae

KW - hederacine A

KW - hederacine 13

KW - tropane alkaloid

KW - colon cancer

KW - MTT

KW - STRUCTURE ELUCIDATION

KW - MULTIDRUG-RESISTANCE

M3 - Article

SN - 1934-578X

VL - 1

SP - 33

EP - 35

JO - Natural Product Communications

JF - Natural Product Communications

IS - 1

ER -

Hederacine A and Hederacine B from Glechoma hederaceae Inhibit the growth of Colorectal Cancer Cells in vitro

Abstract

UN SDGs

Keywords

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