Human tumor necrosis factor α influences rainbow trout Oncorhynchus mykiss leucocyte responses

Laura J. Hardie; Leslie H. Chappell; Christopher J. Secombes

doi:10.1016/0165-2427(94)90016-7

Human tumor necrosis factor α influences rainbow trout Oncorhynchus mykiss leucocyte responses

Laura J. Hardie^*
, Leslie H. Chappell
, Christopher J. Secombes

^*Corresponding author for this work

Aberdeen Centre For Environmental Sustainability

University of Aberdeen
Department of Zoology

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Abstract

Human recombinant tumor necrosis factor α (rTNFα) and rainbow trout macrophage activating factor (postulated γ-interferon (γ-IFN) analogue) synergised to elevate the respiratory burst activity of trout macrophages. This elevated response may parallel phenomena described in mammals where TNFα and γ-IFN commonly synergise. Human rTNFα also synergised with mitogenic stimuli to heighten proliferation responses of trout head kidney leucocytes. These data are indicative of a conserved TNFα receptor on trout leucocytes (and possibly the TNFα molecule itself) and support the notion of an interactive cytokine network regulating immune responses in fish.

Original language	English
Pages (from-to)	73-84
Number of pages	12
Journal	Veterinary Immunology and Immunopathology
Volume	40
Issue number	1
DOIs	https://doi.org/10.1016/0165-2427(94)90016-7
Publication status	Published - Jan 1994

Funding

This work was supportebdy a grant( AG1/551) from AFRC.

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abstract = "Human recombinant tumor necrosis factor α (rTNFα) and rainbow trout macrophage activating factor (postulated γ-interferon (γ-IFN) analogue) synergised to elevate the respiratory burst activity of trout macrophages. This elevated response may parallel phenomena described in mammals where TNFα and γ-IFN commonly synergise. Human rTNFα also synergised with mitogenic stimuli to heighten proliferation responses of trout head kidney leucocytes. These data are indicative of a conserved TNFα receptor on trout leucocytes (and possibly the TNFα molecule itself) and support the notion of an interactive cytokine network regulating immune responses in fish.",

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AB - Human recombinant tumor necrosis factor α (rTNFα) and rainbow trout macrophage activating factor (postulated γ-interferon (γ-IFN) analogue) synergised to elevate the respiratory burst activity of trout macrophages. This elevated response may parallel phenomena described in mammals where TNFα and γ-IFN commonly synergise. Human rTNFα also synergised with mitogenic stimuli to heighten proliferation responses of trout head kidney leucocytes. These data are indicative of a conserved TNFα receptor on trout leucocytes (and possibly the TNFα molecule itself) and support the notion of an interactive cytokine network regulating immune responses in fish.

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ER -

Human tumor necrosis factor α influences rainbow trout Oncorhynchus mykiss leucocyte responses

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