Hysteroscopic resection of a uterine caesarean scar defect (niche) in women with postmenstrual spotting: a randomised controlled trial

A. J.M.W. Vervoort, L. F. van der Voet, W. J.K. Hehenkamp, A. L. Thurkow, P. J.M. van Kesteren, H. Quartero, W. Kuchenbecker, M. Bongers, P. Geomini, L. H.M. de Vleeschouwer, M. H.A. van Hooff, H. van Vliet, S. Veersema, W. B. Renes, K. Oude Rengerink, S. E. Zwolsman, H. A.M. Brölmann, B. W.J. Mol, J. A.F. Huirne* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Objective: To compare the effectiveness of a hysteroscopic niche resection versus no treatment in women with postmenstrual spotting and a uterine caesarean scar defect. Design: Multicentre randomised controlled trial. Setting: Eleven hospitals collaborating in a consortium for women's health research in the Netherlands. Population: Women reporting postmenstrual spotting after a caesarean section who had a niche with a residual myometrium of ≥3 mm, measured during sonohysterography. Methods: Women were randomly allocated to hysteroscopic niche resection or expectant management for 6 months. Main outcome measures: The primary outcome was the number of days of postmenstrual spotting 6 months after randomisation. Secondary outcomes were spotting at the end of menstruation, intermenstrual spotting, dysuria, sonographic niche measurements, surgical parameters, quality of lifel.macrae@abdn.ac.uk, women's satisfaction, sexual function, and additional therapy. Outcomes were measured at 3 months and, except for niche measurements, also at 6 months after randomisation. Results: We randomised 52 women to hysteroscopic niche resection and 51 women to expectant management. The median number of days of postmenstrual spotting at baseline was 8 days in both groups. At 6 months after randomisation, the median number of days of postmenstrual spotting was 4 days (interquartile range, IQR 2–7 days) in the intervention group and 7 days (IQR 3–10 days) in the control group (P = 0.04); on a scale of 0–10, discomfort as a result of spotting had a median score of 2 (IQR 0–7) in the intervention group, compared with 7 (IQR 0–8) in the control group (P = 0.02). Conclusions: In women with a niche with a residual myometrium of ≥3 mm, hysteroscopic niche resection reduced postmenstrual spotting and spotting-related discomfort. Tweetable abstract: A hysteroscopic niche resection is an effective treatment to reduce niche-related spotting.

Original languageEnglish
Pages (from-to)326-334
Number of pages9
JournalBJOG: An International Journal of Obstetrics and Gynaecology
Issue number3
Early online date5 Jul 2017
Publication statusPublished - Feb 2018

Bibliographical note

This study is funded by ZonMw, a Dutch organization for Health Research and Development (project number 80-82305-97-12030) and was co-funded by the VU University Medical Centre Amsterdam. These sponsors had no role in the study design, data collection, data analysis, data interpretation or writing of this article.

Data Availability Statement

Additional Supporting Information may be found in the online version of this article


  • Abnormal uterine bleeding
  • caesarean section
  • hysteroscopic resection
  • niche
  • postmenstrual spotting


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