Immunohistochemical detection of ERβ in breast cancer: Towards more detailed receptor profiling?

G. P. Skliris; P. J. Carder; M. R.J. Lansdown; V. Speirs

doi:10.1054/bjoc.2001.1721

Immunohistochemical detection of ERβ in breast cancer: Towards more detailed receptor profiling?

G. P. Skliris
, P. J. Carder
, M. R.J. Lansdown
, V. Speirs^*

^*Corresponding author for this work

University of Leeds
St James's University Hospital

Research output: Contribution to journal › Article › peer-review

86 Citations (Scopus)

Abstract

Oestrogen receptor (ER) is used routinely to predict endocrine responsiveness in patients with breast cancer. A second ER, ERβ has been described but its significance remains undefined; most studies have described mRNA levels rather than protein expression. Here, we demonstrate for the first time, immunohistochemical detection of ERβ in archival breast tumours.

Original language	English
Pages (from-to)	1095-1098
Number of pages	4
Journal	British Journal of Cancer
Volume	84
Issue number	8
DOIs	https://doi.org/10.1054/bjoc.2001.1721
Publication status	Published - 20 Apr 2001
Externally published	Yes

Funding

We thank Yorkshire Cancer Research and Northern and Yorkshire NHS Executive for financial support. Thanks to Jane Ramsdale for technical assistance.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Breast cancer
ERβ
Formalin-fixed
Immunohistochemistry
Paraffin-embedded material

Access to Document

10.1054/bjoc.2001.1721Licence: CC BY

Cite this

@article{eb256b43d1ba40f3a17269305ae139af,

title = "Immunohistochemical detection of ERβ in breast cancer: Towards more detailed receptor profiling?",

abstract = "Oestrogen receptor (ER) is used routinely to predict endocrine responsiveness in patients with breast cancer. A second ER, ERβ has been described but its significance remains undefined; most studies have described mRNA levels rather than protein expression. Here, we demonstrate for the first time, immunohistochemical detection of ERβ in archival breast tumours.",

keywords = "Breast cancer, ERβ, Formalin-fixed, Immunohistochemistry, Paraffin-embedded material",

author = "Skliris, \{G. P.\} and Carder, \{P. J.\} and Lansdown, \{M. R.J.\} and V. Speirs",

year = "2001",

month = apr,

day = "20",

doi = "10.1054/bjoc.2001.1721",

language = "English",

volume = "84",

pages = "1095--1098",

journal = "British Journal of Cancer",

issn = "0007-0920",

publisher = "Springer Nature",

number = "8",

}

TY - JOUR

T1 - Immunohistochemical detection of ERβ in breast cancer

T2 - Towards more detailed receptor profiling?

AU - Skliris, G. P.

AU - Carder, P. J.

AU - Lansdown, M. R.J.

AU - Speirs, V.

PY - 2001/4/20

Y1 - 2001/4/20

N2 - Oestrogen receptor (ER) is used routinely to predict endocrine responsiveness in patients with breast cancer. A second ER, ERβ has been described but its significance remains undefined; most studies have described mRNA levels rather than protein expression. Here, we demonstrate for the first time, immunohistochemical detection of ERβ in archival breast tumours.

AB - Oestrogen receptor (ER) is used routinely to predict endocrine responsiveness in patients with breast cancer. A second ER, ERβ has been described but its significance remains undefined; most studies have described mRNA levels rather than protein expression. Here, we demonstrate for the first time, immunohistochemical detection of ERβ in archival breast tumours.

KW - Breast cancer

KW - ERβ

KW - Formalin-fixed

KW - Immunohistochemistry

KW - Paraffin-embedded material

UR - https://www.scopus.com/pages/publications/0035918141

U2 - 10.1054/bjoc.2001.1721

DO - 10.1054/bjoc.2001.1721

M3 - Article

C2 - 11308260

AN - SCOPUS:0035918141

SN - 0007-0920

VL - 84

SP - 1095

EP - 1098

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 8

ER -

Immunohistochemical detection of ERβ in breast cancer: Towards more detailed receptor profiling?

Abstract

Funding

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this