In utero exposure to cigarette smoke and NAFLD pathways: Sex and age specific effects in the human fetus

C. Talia; P. Filis; U. Soffientini; B. Lucendo-Villarin; A. Douglas; D. Hay; S. Shaw; J. P. Iredale; M. J. Swortwood; M. A. Huestis; M. Bellingham; L. Connolly; P. J. O'Shaughnessy; P. A. Fowler

doi:10.1016/j.toxlet.2018.06.064

In utero exposure to cigarette smoke and NAFLD pathways: Sex and age specific effects in the human fetus

C. Talia^* (Corresponding Author), P. Filis, U. Soffientini, B. Lucendo-Villarin, A. Douglas, D. Hay, S. Shaw, J. P. Iredale, M. J. Swortwood, M. A. Huestis, M. Bellingham, L. Connolly, P. J. O'Shaughnessy, P. A. Fowler

^*Corresponding author for this work

Research output: Contribution to journal › Abstract › peer-review

Abstract

Background: Non-alcoholic fatty liver disease (NAFLD) is the major cause of chronic liver disease worldwide. In utero exposure to endocrine disruptors might cause obesogenic effects and the reprogramming of hepatic set points, influencing the initiation of the disease later in life. Maternal smoking, a unique model of real early-life exposure, is associated with increased risk of obesity and metabolic syndrome in offspring. We investigated effects of maternal smoking on human fetal liver pathways related to NAFLD pathogenesis.

Original language	English
Pages (from-to)	S63-S64
Number of pages	2
Journal	Toxicology Letters
Volume	295
Issue number	Supplement 1
Early online date	12 Sept 2018
DOIs	https://doi.org/10.1016/j.toxlet.2018.06.064
Publication status	Published - 10 Oct 2018
Event	54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box - Brussels, Belgium Duration: 2 Sept 2018 → 5 Sept 2018

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Part of special issue:
ABSTRACTS of the 54th Congress of the European Societies of Toxicology (EUROTOX 2018) TOXICOLOGY OUT OF THE BOX Brussels, Belgium, 2nd – 5th of September, 2018

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Talia, C., Filis, P., Soffientini, U., Lucendo-Villarin, B., Douglas, A., Hay, D., Shaw, S., Iredale, J. P., Swortwood, M. J., Huestis, M. A., Bellingham, M., Connolly, L., O'Shaughnessy, P. J., & Fowler, P. A. (2018). In utero exposure to cigarette smoke and NAFLD pathways: Sex and age specific effects in the human fetus. Toxicology Letters, 295(Supplement 1), S63-S64. https://doi.org/10.1016/j.toxlet.2018.06.064

Talia, C, Filis, P, Soffientini, U, Lucendo-Villarin, B, Douglas, A, Hay, D, Shaw, S, Iredale, JP, Swortwood, MJ, Huestis, MA, Bellingham, M, Connolly, L, O'Shaughnessy, PJ & Fowler, PA 2018, 'In utero exposure to cigarette smoke and NAFLD pathways: Sex and age specific effects in the human fetus', Toxicology Letters, vol. 295, no. Supplement 1, pp. S63-S64. https://doi.org/10.1016/j.toxlet.2018.06.064

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title = "In utero exposure to cigarette smoke and NAFLD pathways: Sex and age specific effects in the human fetus",

abstract = "Background: Non-alcoholic fatty liver disease (NAFLD) is the major cause of chronic liver disease worldwide. In utero exposure to endocrine disruptors might cause obesogenic effects and the reprogramming of hepatic set points, influencing the initiation of the disease later in life. Maternal smoking, a unique model of real early-life exposure, is associated with increased risk of obesity and metabolic syndrome in offspring. We investigated effects of maternal smoking on human fetal liver pathways related to NAFLD pathogenesis.",

author = "C. Talia and P. Filis and U. Soffientini and B. Lucendo-Villarin and A. Douglas and D. Hay and S. Shaw and Iredale, {J. P.} and Swortwood, {M. J.} and Huestis, {M. A.} and M. Bellingham and L. Connolly and O'Shaughnessy, {P. J.} and Fowler, {P. A.}",

note = "Part of special issue: ABSTRACTS of the 54th Congress of the European Societies of Toxicology (EUROTOX 2018) TOXICOLOGY OUT OF THE BOX Brussels, Belgium, 2nd – 5th of September, 2018; 54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box ; Conference date: 02-09-2018 Through 05-09-2018",

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T2 - 54th Congress of the European-Societies-of-Toxicology (EUROTOX) - Toxicology Out of the Box

AU - Talia, C.

AU - Filis, P.

AU - Soffientini, U.

AU - Lucendo-Villarin, B.

AU - Douglas, A.

AU - Hay, D.

AU - Shaw, S.

AU - Iredale, J. P.

AU - Swortwood, M. J.

AU - Huestis, M. A.

AU - Bellingham, M.

AU - Connolly, L.

AU - O'Shaughnessy, P. J.

AU - Fowler, P. A.

N1 - Part of special issue: ABSTRACTS of the 54th Congress of the European Societies of Toxicology (EUROTOX 2018) TOXICOLOGY OUT OF THE BOX Brussels, Belgium, 2nd – 5th of September, 2018

PY - 2018/10/10

Y1 - 2018/10/10

N2 - Background: Non-alcoholic fatty liver disease (NAFLD) is the major cause of chronic liver disease worldwide. In utero exposure to endocrine disruptors might cause obesogenic effects and the reprogramming of hepatic set points, influencing the initiation of the disease later in life. Maternal smoking, a unique model of real early-life exposure, is associated with increased risk of obesity and metabolic syndrome in offspring. We investigated effects of maternal smoking on human fetal liver pathways related to NAFLD pathogenesis.

AB - Background: Non-alcoholic fatty liver disease (NAFLD) is the major cause of chronic liver disease worldwide. In utero exposure to endocrine disruptors might cause obesogenic effects and the reprogramming of hepatic set points, influencing the initiation of the disease later in life. Maternal smoking, a unique model of real early-life exposure, is associated with increased risk of obesity and metabolic syndrome in offspring. We investigated effects of maternal smoking on human fetal liver pathways related to NAFLD pathogenesis.

U2 - 10.1016/j.toxlet.2018.06.064

DO - 10.1016/j.toxlet.2018.06.064

M3 - Abstract

SN - 0378-4274

VL - 295

SP - S63-S64

JO - Toxicology Letters

JF - Toxicology Letters

IS - Supplement 1

Y2 - 2 September 2018 through 5 September 2018

ER -

In utero exposure to cigarette smoke and NAFLD pathways: Sex and age specific effects in the human fetus

Abstract

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