Abstract
Background and objective: With the introduction of the antifibrotic drugs targeting progressive pulmonary fibroses, it becomes imperative to provide reliable contemporary estimates of the most common interstitial lung diseases.
We then aimed at providing contemporary estimates of the incidence and survival of idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis (HP) and connective tissue disease associated interstitial lung disease (CTD-ILDs), and to compare their survival to that of the general population.
To do this we have used data extracted from the Optimum Patient Care Research Database (OPCRD).
Methods: In this matched cohort study, we extracted incident cases of HP, CTD-ILD and IPF, and age and sex matched controls for each case, for the years 2010-2019. We calculated annual incidence rates, and analysed incidence trends over time using segmented regression modelling. We estimated survival for cases and controls using the Kaplan–Meier model.
Results: We extracted data for 18,914 incident cases of interstitial lung diseases between 2010 and 2019 from the OPRCD. Incidence rates varied across the different diseases, with rates of 18.12, 7.96, and 2.63 per 100,000 person-years for IPF, CTD-ILD and HP, respectively. 5-year survival for IPF, CTD-ILD and HP was 40%, 54% and 66% respectively, and this was generally approximately 50%
51 lower than that of the general population.
Conclusion: Our population-based study emphasizes the considerable burden of interstitial lung diseases, with more than 20,000 new cases diagnosed each year in the UK, many of who will be eligible for antifibrotic drugs.
We then aimed at providing contemporary estimates of the incidence and survival of idiopathic pulmonary fibrosis (IPF), hypersensitivity pneumonitis (HP) and connective tissue disease associated interstitial lung disease (CTD-ILDs), and to compare their survival to that of the general population.
To do this we have used data extracted from the Optimum Patient Care Research Database (OPCRD).
Methods: In this matched cohort study, we extracted incident cases of HP, CTD-ILD and IPF, and age and sex matched controls for each case, for the years 2010-2019. We calculated annual incidence rates, and analysed incidence trends over time using segmented regression modelling. We estimated survival for cases and controls using the Kaplan–Meier model.
Results: We extracted data for 18,914 incident cases of interstitial lung diseases between 2010 and 2019 from the OPRCD. Incidence rates varied across the different diseases, with rates of 18.12, 7.96, and 2.63 per 100,000 person-years for IPF, CTD-ILD and HP, respectively. 5-year survival for IPF, CTD-ILD and HP was 40%, 54% and 66% respectively, and this was generally approximately 50%
51 lower than that of the general population.
Conclusion: Our population-based study emphasizes the considerable burden of interstitial lung diseases, with more than 20,000 new cases diagnosed each year in the UK, many of who will be eligible for antifibrotic drugs.
| Original language | English |
|---|---|
| Journal | ERJ Open Research |
| Publication status | Accepted/In press - 2 Oct 2024 |
Data Availability Statement
The data set supporting the conclusions of this article was derived from the Optimum Patient Care Research Database (www.opcrd.co.uk). The authors do not have permission to give public access to the study data set; researchers may request access to OPCRD data for their own purposes. Access to OPCRD can be made via the OPCRD website (https://opcrd.co.uk/our-database/ data-requests/) orvia the enquiries email [email protected].
Keywords
- Interstitial lung disease
- epidemiology
- Idiopathic
- Pulmonary Fibrosis
- Hypersensitivity Pneumonitis
- Connective Tissue Disease-interstitial lung disease
- incidence
- survival