Increased Body Mass Index is Associated with Sarcopenia and Related Outcomes

Nurul Nabilah Akmal Hashim; Sumaiyah Mat; Phyo Kyaw Myint; Sheng Hui Kioh; Mirela Delibegovic; Ai-Vyrn  Chin; Shahrul Bahyah  Kamaruzzaman; Noran Naqiah  Hair; Selina  Khoo; Tan Maw Pin

doi:10.1111/eci.13874

Increased Body Mass Index is Associated with Sarcopenia and Related Outcomes

Nurul Nabilah Akmal Hashim, Sumaiyah Mat, Phyo Kyaw Myint, Sheng Hui Kioh, Mirela Delibegovic, Ai-Vyrn Chin, Shahrul Bahyah Kamaruzzaman, Noran Naqiah Hair, Selina Khoo, Tan Maw Pin^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

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Abstract

Sarcopenia, characterized by loss of lean body mass, muscle strength and physical performance in older adults, is a geriatric syndrome. Physical inactivity, increasing sedentary behaviour, as well as poor nutritional and health status enhance the progressive decline of muscle function and strength among older adults. Previous studies have highlighted being underweight as an important risk factor for sarcopenia which may be compounded by progressive loss of body mass and muscle strength during ageing. However, total body fat is known to increase with age. Sarcopenia and excessive adiposity may, therefore, share similar pathophysiology since both involve low-grade inflammation with accelerated muscle catabolism.

Original language	English
Article number	e13874
Number of pages	8
Journal	European Journal of Clinical Investigation
Volume	53
Issue number	2
Early online date	25 Sept 2022
DOIs	https://doi.org/10.1111/eci.13874
Publication status	Published - 1 Feb 2023

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Acknowledgement
This study was supported by grant from the Ministry of Higher Education Malaysia, Fundamental Research Grant Scheme (FRGS/1/2019/SKK02/UM/01/1).

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title = "Increased Body Mass Index is Associated with Sarcopenia and Related Outcomes",

abstract = "Sarcopenia, characterized by loss of lean body mass, muscle strength and physical performance in older adults, is a geriatric syndrome. Physical inactivity, increasing sedentary behaviour, as well as poor nutritional and health status enhance the progressive decline of muscle function and strength among older adults. Previous studies have highlighted being underweight as an important risk factor for sarcopenia which may be compounded by progressive loss of body mass and muscle strength during ageing. However, total body fat is known to increase with age. Sarcopenia and excessive adiposity may, therefore, share similar pathophysiology since both involve low-grade inflammation with accelerated muscle catabolism.",

author = "Hashim, {Nurul Nabilah Akmal} and Sumaiyah Mat and Myint, {Phyo Kyaw} and Kioh, {Sheng Hui} and Mirela Delibegovic and Ai-Vyrn Chin and Kamaruzzaman, {Shahrul Bahyah} and Hair, {Noran Naqiah} and Selina Khoo and Pin, {Tan Maw}",

note = "Acknowledgement This study was supported by grant from the Ministry of Higher Education Malaysia, Fundamental Research Grant Scheme (FRGS/1/2019/SKK02/UM/01/1). ",

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doi = "10.1111/eci.13874",

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T1 - Increased Body Mass Index is Associated with Sarcopenia and Related Outcomes

AU - Hashim, Nurul Nabilah Akmal

AU - Mat, Sumaiyah

AU - Myint, Phyo Kyaw

AU - Kioh, Sheng Hui

AU - Delibegovic, Mirela

AU - Chin, Ai-Vyrn

AU - Kamaruzzaman, Shahrul Bahyah

AU - Hair, Noran Naqiah

AU - Khoo, Selina

AU - Pin, Tan Maw

N1 - Acknowledgement This study was supported by grant from the Ministry of Higher Education Malaysia, Fundamental Research Grant Scheme (FRGS/1/2019/SKK02/UM/01/1).

PY - 2023/2/1

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N2 - Sarcopenia, characterized by loss of lean body mass, muscle strength and physical performance in older adults, is a geriatric syndrome. Physical inactivity, increasing sedentary behaviour, as well as poor nutritional and health status enhance the progressive decline of muscle function and strength among older adults. Previous studies have highlighted being underweight as an important risk factor for sarcopenia which may be compounded by progressive loss of body mass and muscle strength during ageing. However, total body fat is known to increase with age. Sarcopenia and excessive adiposity may, therefore, share similar pathophysiology since both involve low-grade inflammation with accelerated muscle catabolism.

AB - Sarcopenia, characterized by loss of lean body mass, muscle strength and physical performance in older adults, is a geriatric syndrome. Physical inactivity, increasing sedentary behaviour, as well as poor nutritional and health status enhance the progressive decline of muscle function and strength among older adults. Previous studies have highlighted being underweight as an important risk factor for sarcopenia which may be compounded by progressive loss of body mass and muscle strength during ageing. However, total body fat is known to increase with age. Sarcopenia and excessive adiposity may, therefore, share similar pathophysiology since both involve low-grade inflammation with accelerated muscle catabolism.

U2 - 10.1111/eci.13874

DO - 10.1111/eci.13874

M3 - Letter

C2 - 36120810

SN - 0014-2972

VL - 53

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

IS - 2

M1 - e13874

ER -

Increased Body Mass Index is Associated with Sarcopenia and Related Outcomes

Abstract

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