Inhibitors of PTP1B/NCK1 interaction and methods of making and using same

Mirela Delibegovic; Sergio Dall'Angelo; Meghan Marie Hamer; Ruta Dekeryte; Andrew Robert McEwan; Iain Greig

Inhibitors of PTP1B/NCK1 interaction and methods of making and using same

Mirela Delibegovic (Inventor), Sergio Dall'Angelo (Inventor), Meghan Marie Hamer (Inventor), Ruta Dekeryte (Inventor), Andrew Robert McEwan (Inventor), Iain Greig (Inventor)

Research output: Patent

Abstract

The invention relates generally to synthetic peptides which bind NCK1. The invention further relates to methods of using the peptides for inhibiting an interaction between NCK1 and PTP1B, and for treating a disease or disorder associated with insulin resistance, including type 2 diabetes and obesity.

Original language	English
Patent number	WO/2024/178250
IPC	C07K 7/06 2006.1,A61K 38/00 2006.1 ,A61K 38/08 2019.1 ,A61P 3/10 2006.1 ,A61P 43/00 2006.1 ,C07K 7/08 2006.1
Priority date	22/02/23
Filing date	22/02/24
Publication status	Published - 29 Aug 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2024178250&_cid=P10-M0FOXW-70692-1Licence: Unspecified

Cite this

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title = "Inhibitors of PTP1B/NCK1 interaction and methods of making and using same",

abstract = "The invention relates generally to synthetic peptides which bind NCK1. The invention further relates to methods of using the peptides for inhibiting an interaction between NCK1 and PTP1B, and for treating a disease or disorder associated with insulin resistance, including type 2 diabetes and obesity.",

author = "Mirela Delibegovic and Sergio Dall'Angelo and Hamer, {Meghan Marie} and Ruta Dekeryte and McEwan, {Andrew Robert} and Iain Greig",

year = "2024",

month = aug,

day = "29",

language = "English",

publisher = "Radella Pharmaceuticals LLC",

type = "Patent",

note = "WO/2024/178250; C07K 7/06 2006.1,A61K 38/00 2006.1 ,A61K 38/08 2019.1 ,A61P 3/10 2006.1 ,A61P 43/00 2006.1 ,C07K 7/08 2006.1",

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TY - PAT

T1 - Inhibitors of PTP1B/NCK1 interaction and methods of making and using same

AU - Delibegovic, Mirela

AU - Dall'Angelo, Sergio

AU - Hamer, Meghan Marie

AU - Dekeryte, Ruta

AU - McEwan, Andrew Robert

AU - Greig, Iain

PY - 2024/8/29

Y1 - 2024/8/29

N2 - The invention relates generally to synthetic peptides which bind NCK1. The invention further relates to methods of using the peptides for inhibiting an interaction between NCK1 and PTP1B, and for treating a disease or disorder associated with insulin resistance, including type 2 diabetes and obesity.

AB - The invention relates generally to synthetic peptides which bind NCK1. The invention further relates to methods of using the peptides for inhibiting an interaction between NCK1 and PTP1B, and for treating a disease or disorder associated with insulin resistance, including type 2 diabetes and obesity.

M3 - Patent

M1 - WO/2024/178250

Y2 - 2024/02/22

PB - Radella Pharmaceuticals LLC

ER -

Inhibitors of PTP1B/NCK1 interaction and methods of making and using same

Abstract

UN SDGs

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