Inverse Association Between Gluteofemoral Obesity and Risk of Barrett's Esophagus in a Pooled Analysis

Bradley J. Kendall; Joel H. Rubenstein; Michael B. Cook; Thomas L. Vaughan; Lesley A. Anderson; Liam J. Murray; Nicholas J. Shaheen; Douglas A. Corley; Apoorva K. Chandar; Li Li; Katarina B. Greer; Amitabh Chak; Hashem B. El-Serag; David C. Whiteman; Aaron P. Thrift

doi:10.1016/j.cgh.2016.05.032

Inverse Association Between Gluteofemoral Obesity and Risk of Barrett's Esophagus in a Pooled Analysis

Bradley J. Kendall, Joel H. Rubenstein, Michael B. Cook, Thomas L. Vaughan, Lesley A. Anderson, Liam J. Murray, Nicholas J. Shaheen, Douglas A. Corley, Apoorva K. Chandar, Li Li, Katarina B. Greer, Amitabh Chak, Hashem B. El-Serag, David C. Whiteman, Aaron P. Thrift^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Background & Aims Gluteofemoral obesity (determined by measurement of subcutaneous fat in the hip and thigh regions) could reduce risks of cardiovascular and diabetic disorders associated with abdominal obesity. We evaluated whether gluteofemoral obesity also reduces the risk of Barrett's esophagus (BE), a premalignant lesion associated with abdominal obesity. Methods We collected data from non-Hispanic white participants in 8 studies in the Barrett's and Esophageal Adenocarcinoma Consortium. We compared measures of hip circumference (as a proxy for gluteofemoral obesity) from cases of BE (n = 1559) separately with 2 control groups: 2557 population-based controls and 2064 individuals with gastroesophageal reflux disease (GERD controls). Study-specific odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated using individual participant data and multivariable logistic regression and combined using a random-effects meta-analysis. Results We found an inverse relationship between hip circumference and BE (OR per 5-cm increase, 0.88; 95% CI, 0.81–0.96), compared with population-based controls in a multivariable model that included waist circumference. This association was not observed in models that did not include waist circumference. Similar results were observed in analyses stratified by frequency of GERD symptoms. The inverse association with hip circumference was statistically significant only among men (vs population-based controls: OR, 0.85; 95% CI, 0.76–0.96 for men; OR, 0.93; 95% CI, 0.74–1.16 for women). For men, within each category of waist circumference, a larger hip circumference was associated with a decreased risk of BE. Increasing waist circumference was associated with an increased risk of BE in the mutually adjusted population-based and GERD control models. Conclusions Although abdominal obesity is associated with an increased risk of BE, there is an inverse association between gluteofemoral obesity and BE, particularly among men.

Original language	English
Pages (from-to)	1412-1419.e3
Number of pages	11
Journal	Clinical Gastroenterology and Hepatology
Volume	14
Issue number	10
Early online date	2 Jun 2016
DOIs	https://doi.org/10.1016/j.cgh.2016.05.032
Publication status	Published - 1 Oct 2016

Bibliographical note

Funding: This work was supported by the National Institutes of Health RO1 DK63616 (D.A.C.), 1R21DK077742 (N.J.S. and D.A.C.), K23DK59311 (N.J.S.), R03 DK75842 (N.J.S.), K23DK079291 (J.H.R.), R01 CA116845 (H.B.E.-S.), K24-04-107 (H.B.E.-S.); NCI grant U54CA163060 (A.C.); the Intramural Program of the National Institutes of Health (M.B.C.); an Ireland–Northern Ireland cooperation research project grant sponsored by the Northern Ireland Research and Development Office and the Health Research Board, Ireland (Factors Influencing the Barrett’s/Adenocarcinoma Relationship) (RES/1699/01N/S to L.J.M.); the Study of Digestive Health grant NCI RO1 CA 001833 (D.C.W.); the Study of Reflux Disease grant NCI R01 CA72866 (T.L.V.); the Established Investigator Award in Cancer Prevention and Control grant K05 CA124911 (T.L.V.); the US Department of Veterans Affairs grant CSRD Merit I01-CX000899 (J.H.R.); and US Public Health Service research grant R21 CA135692 (A.C.).

Keywords

BEACON
Epidemiology
Esophageal Cancer
Obesity
Risk Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Kendall, B. J., Rubenstein, J. H., Cook, M. B., Vaughan, T. L., Anderson, L. A., Murray, L. J., Shaheen, N. J., Corley, D. A., Chandar, A. K., Li, L., Greer, K. B., Chak, A., El-Serag, H. B., Whiteman, D. C., & Thrift, A. P. (2016). Inverse Association Between Gluteofemoral Obesity and Risk of Barrett's Esophagus in a Pooled Analysis. Clinical Gastroenterology and Hepatology, 14(10), 1412-1419.e3. https://doi.org/10.1016/j.cgh.2016.05.032

Kendall, BJ, Rubenstein, JH, Cook, MB, Vaughan, TL, Anderson, LA, Murray, LJ, Shaheen, NJ, Corley, DA, Chandar, AK, Li, L, Greer, KB, Chak, A, El-Serag, HB, Whiteman, DC & Thrift, AP 2016, 'Inverse Association Between Gluteofemoral Obesity and Risk of Barrett's Esophagus in a Pooled Analysis', Clinical Gastroenterology and Hepatology, vol. 14, no. 10, pp. 1412-1419.e3. https://doi.org/10.1016/j.cgh.2016.05.032

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title = "Inverse Association Between Gluteofemoral Obesity and Risk of Barrett's Esophagus in a Pooled Analysis",

abstract = "Background & Aims Gluteofemoral obesity (determined by measurement of subcutaneous fat in the hip and thigh regions) could reduce risks of cardiovascular and diabetic disorders associated with abdominal obesity. We evaluated whether gluteofemoral obesity also reduces the risk of Barrett's esophagus (BE), a premalignant lesion associated with abdominal obesity. Methods We collected data from non-Hispanic white participants in 8 studies in the Barrett's and Esophageal Adenocarcinoma Consortium. We compared measures of hip circumference (as a proxy for gluteofemoral obesity) from cases of BE (n = 1559) separately with 2 control groups: 2557 population-based controls and 2064 individuals with gastroesophageal reflux disease (GERD controls). Study-specific odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated using individual participant data and multivariable logistic regression and combined using a random-effects meta-analysis. Results We found an inverse relationship between hip circumference and BE (OR per 5-cm increase, 0.88; 95% CI, 0.81–0.96), compared with population-based controls in a multivariable model that included waist circumference. This association was not observed in models that did not include waist circumference. Similar results were observed in analyses stratified by frequency of GERD symptoms. The inverse association with hip circumference was statistically significant only among men (vs population-based controls: OR, 0.85; 95% CI, 0.76–0.96 for men; OR, 0.93; 95% CI, 0.74–1.16 for women). For men, within each category of waist circumference, a larger hip circumference was associated with a decreased risk of BE. Increasing waist circumference was associated with an increased risk of BE in the mutually adjusted population-based and GERD control models. Conclusions Although abdominal obesity is associated with an increased risk of BE, there is an inverse association between gluteofemoral obesity and BE, particularly among men.",

keywords = "BEACON, Epidemiology, Esophageal Cancer, Obesity, Risk Factors",

author = "Kendall, {Bradley J.} and Rubenstein, {Joel H.} and Cook, {Michael B.} and Vaughan, {Thomas L.} and Anderson, {Lesley A.} and Murray, {Liam J.} and Shaheen, {Nicholas J.} and Corley, {Douglas A.} and Chandar, {Apoorva K.} and Li Li and Greer, {Katarina B.} and Amitabh Chak and El-Serag, {Hashem B.} and Whiteman, {David C.} and Thrift, {Aaron P.}",

note = "Funding: This work was supported by the National Institutes of Health RO1 DK63616 (D.A.C.), 1R21DK077742 (N.J.S. and D.A.C.), K23DK59311 (N.J.S.), R03 DK75842 (N.J.S.), K23DK079291 (J.H.R.), R01 CA116845 (H.B.E.-S.), K24-04-107 (H.B.E.-S.); NCI grant U54CA163060 (A.C.); the Intramural Program of the National Institutes of Health (M.B.C.); an Ireland–Northern Ireland cooperation research project grant sponsored by the Northern Ireland Research and Development Office and the Health Research Board, Ireland (Factors Influencing the Barrett{\textquoteright}s/Adenocarcinoma Relationship) (RES/1699/01N/S to L.J.M.); the Study of Digestive Health grant NCI RO1 CA 001833 (D.C.W.); the Study of Reflux Disease grant NCI R01 CA72866 (T.L.V.); the Established Investigator Award in Cancer Prevention and Control grant K05 CA124911 (T.L.V.); the US Department of Veterans Affairs grant CSRD Merit I01-CX000899 (J.H.R.); and US Public Health Service research grant R21 CA135692 (A.C.).",

year = "2016",

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doi = "10.1016/j.cgh.2016.05.032",

language = "English",

volume = "14",

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TY - JOUR

T1 - Inverse Association Between Gluteofemoral Obesity and Risk of Barrett's Esophagus in a Pooled Analysis

AU - Kendall, Bradley J.

AU - Rubenstein, Joel H.

AU - Cook, Michael B.

AU - Vaughan, Thomas L.

AU - Anderson, Lesley A.

AU - Murray, Liam J.

AU - Shaheen, Nicholas J.

AU - Corley, Douglas A.

AU - Chandar, Apoorva K.

AU - Li, Li

AU - Greer, Katarina B.

AU - Chak, Amitabh

AU - El-Serag, Hashem B.

AU - Whiteman, David C.

AU - Thrift, Aaron P.

N1 - Funding: This work was supported by the National Institutes of Health RO1 DK63616 (D.A.C.), 1R21DK077742 (N.J.S. and D.A.C.), K23DK59311 (N.J.S.), R03 DK75842 (N.J.S.), K23DK079291 (J.H.R.), R01 CA116845 (H.B.E.-S.), K24-04-107 (H.B.E.-S.); NCI grant U54CA163060 (A.C.); the Intramural Program of the National Institutes of Health (M.B.C.); an Ireland–Northern Ireland cooperation research project grant sponsored by the Northern Ireland Research and Development Office and the Health Research Board, Ireland (Factors Influencing the Barrett’s/Adenocarcinoma Relationship) (RES/1699/01N/S to L.J.M.); the Study of Digestive Health grant NCI RO1 CA 001833 (D.C.W.); the Study of Reflux Disease grant NCI R01 CA72866 (T.L.V.); the Established Investigator Award in Cancer Prevention and Control grant K05 CA124911 (T.L.V.); the US Department of Veterans Affairs grant CSRD Merit I01-CX000899 (J.H.R.); and US Public Health Service research grant R21 CA135692 (A.C.).

PY - 2016/10/1

Y1 - 2016/10/1

N2 - Background & Aims Gluteofemoral obesity (determined by measurement of subcutaneous fat in the hip and thigh regions) could reduce risks of cardiovascular and diabetic disorders associated with abdominal obesity. We evaluated whether gluteofemoral obesity also reduces the risk of Barrett's esophagus (BE), a premalignant lesion associated with abdominal obesity. Methods We collected data from non-Hispanic white participants in 8 studies in the Barrett's and Esophageal Adenocarcinoma Consortium. We compared measures of hip circumference (as a proxy for gluteofemoral obesity) from cases of BE (n = 1559) separately with 2 control groups: 2557 population-based controls and 2064 individuals with gastroesophageal reflux disease (GERD controls). Study-specific odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated using individual participant data and multivariable logistic regression and combined using a random-effects meta-analysis. Results We found an inverse relationship between hip circumference and BE (OR per 5-cm increase, 0.88; 95% CI, 0.81–0.96), compared with population-based controls in a multivariable model that included waist circumference. This association was not observed in models that did not include waist circumference. Similar results were observed in analyses stratified by frequency of GERD symptoms. The inverse association with hip circumference was statistically significant only among men (vs population-based controls: OR, 0.85; 95% CI, 0.76–0.96 for men; OR, 0.93; 95% CI, 0.74–1.16 for women). For men, within each category of waist circumference, a larger hip circumference was associated with a decreased risk of BE. Increasing waist circumference was associated with an increased risk of BE in the mutually adjusted population-based and GERD control models. Conclusions Although abdominal obesity is associated with an increased risk of BE, there is an inverse association between gluteofemoral obesity and BE, particularly among men.

AB - Background & Aims Gluteofemoral obesity (determined by measurement of subcutaneous fat in the hip and thigh regions) could reduce risks of cardiovascular and diabetic disorders associated with abdominal obesity. We evaluated whether gluteofemoral obesity also reduces the risk of Barrett's esophagus (BE), a premalignant lesion associated with abdominal obesity. Methods We collected data from non-Hispanic white participants in 8 studies in the Barrett's and Esophageal Adenocarcinoma Consortium. We compared measures of hip circumference (as a proxy for gluteofemoral obesity) from cases of BE (n = 1559) separately with 2 control groups: 2557 population-based controls and 2064 individuals with gastroesophageal reflux disease (GERD controls). Study-specific odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated using individual participant data and multivariable logistic regression and combined using a random-effects meta-analysis. Results We found an inverse relationship between hip circumference and BE (OR per 5-cm increase, 0.88; 95% CI, 0.81–0.96), compared with population-based controls in a multivariable model that included waist circumference. This association was not observed in models that did not include waist circumference. Similar results were observed in analyses stratified by frequency of GERD symptoms. The inverse association with hip circumference was statistically significant only among men (vs population-based controls: OR, 0.85; 95% CI, 0.76–0.96 for men; OR, 0.93; 95% CI, 0.74–1.16 for women). For men, within each category of waist circumference, a larger hip circumference was associated with a decreased risk of BE. Increasing waist circumference was associated with an increased risk of BE in the mutually adjusted population-based and GERD control models. Conclusions Although abdominal obesity is associated with an increased risk of BE, there is an inverse association between gluteofemoral obesity and BE, particularly among men.

KW - BEACON

KW - Epidemiology

KW - Esophageal Cancer

KW - Obesity

KW - Risk Factors

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DO - 10.1016/j.cgh.2016.05.032

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AN - SCOPUS:84991035798

SN - 1542-3565

VL - 14

SP - 1412-1419.e3

JO - Clinical Gastroenterology and Hepatology

JF - Clinical Gastroenterology and Hepatology

IS - 10

ER -

Inverse Association Between Gluteofemoral Obesity and Risk of Barrett's Esophagus in a Pooled Analysis

Abstract

Bibliographical note

Keywords

UN SDGs

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