Kidney biopsy findings in primary Sjögren syndrome

Dana Kidder* (Corresponding Author), Elaine Rutherford, David Kipgen, Stewart Fleming, Colin Geddes, Graham A. Stewart

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


Background: Renal involvement is rare in primary Sjögren syndrome (PSS). In this study, we examined renal biopsy findings in patients with PSS and correlated them with their clinical and renal findings. Methods: Twenty-five patients with PSS who underwent renal biopsies from two renal units in Scotland between 1978 and 2013 were identified from renal biopsy database. We examined the renal morphologic, clinical and renal findings at the time of renal biopsy, renal and patient outcomes. Results: The diagnosis of PSS preceded renal biopsy in 18/25 patients. In this group, the median duration of the disease was 5.5 years. Significant proteinuria, combined microscopic haematuria and proteinuria and reduced renal excretory function were found in 76, 56 and 84% of patients, respectively. The 3-year actuarial patient survival was significantly lower in patients with glomerulonephritis as compared with tubulointerstitial nephritis (66 versus 100%, P = 0.02). There was no difference in 3-year actuarial renal survival between these two groups (92 versus 92%, P = 1.0). Conclusions: Renal biopsy is rare in PSS and often reveals diverse pathological findings. Glomerulonephritis, as compared with tubulointerstitial nephritis, is associated with higher early mortality. Further studies are needed to evaluate the utility of renal biopsy and its impact on disease management.
Original languageEnglish
Pages (from-to)1363-1369
Number of pages7
JournalNephrology Dialysis Transplantation
Issue number8
Early online date27 Mar 2015
Publication statusPublished - 1 Aug 2015

Bibliographical note

The cost of publication of this article is funded by the Endowment fund of the Renal Unit, Ninewells Hospital, Dundee, Scotland.


  • glomerulonephritis
  • immunosuppression
  • kidney biopsy
  • primary Sjögren syndrome
  • tubulointerstitial nephritis


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