Lectin Receptors Expressed on Myeloid Cells

Gordon D Brown, Paul R Crocker

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)


Lectins recognize a diverse array of carbohydrate structures and perform numerous essential biological functions. Here we focus on only two families of lectins, the Siglecs and C-type lectins. Triggering of intracellular signaling cascades following ligand recognition by these receptors can have profound effects on the induction and modulation of immunity. In this chapter, we provide a brief overview of each family and then focus on selected examples that highlight how these lectins can influence myeloid cell functioning in health and disease. Receptors that are discussed include Sn (Siglec-1), CD33 (Siglec-3), and Siglec-5, -7, -8, -9, -10, -11, -14, -15, -E, -F, and -G as well as Dectin-1, MICL, Dectin-2, Mincle/MCL, and the macrophage mannose receptor.

Original languageEnglish
Article numberMCHD-0036-2016
JournalMicrobiology spectrum
Issue number5
Early online date23 Sept 2016
Publication statusPublished - Oct 2016

Bibliographical note

The authors thank the Wellcome Trust, Medical Research Council, and Arthritis Research UK for funding.


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