Markers of low field NMR relaxation features of tissues

Karol  Kołodziejski; Elzbieta Masiewicz; Amnah Saad S Alamri; Vasileios Zampetoulas; Leslie Samuel; Graeme Murray; David Lurie; Lionel Broche; Danuta Kruk

doi:10.1038/s41598-024-74055-7

Markers of low field NMR relaxation features of tissues

Karol Kołodziejski, Elzbieta Masiewicz, Amnah Saad S Alamri, Vasileios Zampetoulas, Leslie Samuel, Graeme Murray, David Lurie, Lionel Broche^* (Corresponding Author), Danuta Kruk

^*Corresponding author for this work

University of Warmia and Mazury in Olsztyn

Research output: Contribution to journal › Article › peer-review

3 Downloads (Pure)

Abstract

This work presents an approach to exploiting Nuclear Magnetic Resonance (NMR) relaxometry data (1H spin-lattice relaxation rates covering the frequency range from below 1 kHz to 10 MHz) for the purpose of differentiating between pathological and reference tissues. Characteristic quantities (markers) that can be obtained in a straightforward manner, not resorting to an advanced analysis of 1H spin-lattice relaxation data, have been identified and compared for pathological and reference colon tissues. Moreover, the relaxation data have been parametrised in terms of Lorentzian spectral densities and the possibility of using the obtained dipolar relaxation constants and correlation times as biomarkers to assess the state of tissues has been discussed. It has also been demonstrated that the relaxation data for the reference and the pathological tissues can be attributed to two groups (for each case). The studies are a step towards exploiting the potential of NMR relaxometry for characterisation of pathological changes in tissues.

Original language	English
Article number	24901
Number of pages	12
Journal	Scientific Reports
Volume	14
Issue number	1
Early online date	22 Oct 2024
DOIs	https://doi.org/10.1038/s41598-024-74055-7
Publication status	Published - 22 Oct 2024

Funding

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 668119 (project “IDentIFY”).This work received support from the EURELAX COST Action CA15209, supported by COST (European Cooperation in Science and Technology).

Funders	Funder number
European Commission	668119

Keywords

Biological physics
Biomarkers
Biophysics
Tumour biomarkers

Access to Document

10.1038/s41598-024-74055-7Licence: CC BY

Kołodziejski_etal_SR_Markers_Of_Low_VoR
This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
Final published version, 2.51 MBLicence: CC BY

Cite this

@article{ed494add4361475cbdc0dd4e936d1183,

title = "Markers of low field NMR relaxation features of tissues",

abstract = "This work presents an approach to exploiting Nuclear Magnetic Resonance (NMR) relaxometry data (1H spin-lattice relaxation rates covering the frequency range from below 1 kHz to 10 MHz) for the purpose of differentiating between pathological and reference tissues. Characteristic quantities (markers) that can be obtained in a straightforward manner, not resorting to an advanced analysis of 1H spin-lattice relaxation data, have been identified and compared for pathological and reference colon tissues. Moreover, the relaxation data have been parametrised in terms of Lorentzian spectral densities and the possibility of using the obtained dipolar relaxation constants and correlation times as biomarkers to assess the state of tissues has been discussed. It has also been demonstrated that the relaxation data for the reference and the pathological tissues can be attributed to two groups (for each case). The studies are a step towards exploiting the potential of NMR relaxometry for characterisation of pathological changes in tissues.",

keywords = "Biological physics, Biomarkers, Biophysics, Tumour biomarkers",

author = "Karol Ko{\l}odziejski and Elzbieta Masiewicz and Alamri, {Amnah Saad S} and Vasileios Zampetoulas and Leslie Samuel and Graeme Murray and David Lurie and Lionel Broche and Danuta Kruk",

year = "2024",

month = oct,

day = "22",

doi = "10.1038/s41598-024-74055-7",

language = "English",

volume = "14",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

number = "1",

}

TY - JOUR

T1 - Markers of low field NMR relaxation features of tissues

AU - Kołodziejski, Karol

AU - Masiewicz, Elzbieta

AU - Alamri, Amnah Saad S

AU - Zampetoulas, Vasileios

AU - Samuel, Leslie

AU - Murray, Graeme

AU - Lurie, David

AU - Broche, Lionel

AU - Kruk, Danuta

PY - 2024/10/22

Y1 - 2024/10/22

N2 - This work presents an approach to exploiting Nuclear Magnetic Resonance (NMR) relaxometry data (1H spin-lattice relaxation rates covering the frequency range from below 1 kHz to 10 MHz) for the purpose of differentiating between pathological and reference tissues. Characteristic quantities (markers) that can be obtained in a straightforward manner, not resorting to an advanced analysis of 1H spin-lattice relaxation data, have been identified and compared for pathological and reference colon tissues. Moreover, the relaxation data have been parametrised in terms of Lorentzian spectral densities and the possibility of using the obtained dipolar relaxation constants and correlation times as biomarkers to assess the state of tissues has been discussed. It has also been demonstrated that the relaxation data for the reference and the pathological tissues can be attributed to two groups (for each case). The studies are a step towards exploiting the potential of NMR relaxometry for characterisation of pathological changes in tissues.

AB - This work presents an approach to exploiting Nuclear Magnetic Resonance (NMR) relaxometry data (1H spin-lattice relaxation rates covering the frequency range from below 1 kHz to 10 MHz) for the purpose of differentiating between pathological and reference tissues. Characteristic quantities (markers) that can be obtained in a straightforward manner, not resorting to an advanced analysis of 1H spin-lattice relaxation data, have been identified and compared for pathological and reference colon tissues. Moreover, the relaxation data have been parametrised in terms of Lorentzian spectral densities and the possibility of using the obtained dipolar relaxation constants and correlation times as biomarkers to assess the state of tissues has been discussed. It has also been demonstrated that the relaxation data for the reference and the pathological tissues can be attributed to two groups (for each case). The studies are a step towards exploiting the potential of NMR relaxometry for characterisation of pathological changes in tissues.

KW - Biological physics

KW - Biomarkers

KW - Biophysics

KW - Tumour biomarkers

U2 - 10.1038/s41598-024-74055-7

DO - 10.1038/s41598-024-74055-7

M3 - Article

C2 - 39438494

SN - 2045-2322

VL - 14

JO - Scientific Reports

JF - Scientific Reports

IS - 1

M1 - 24901

ER -

Markers of low field NMR relaxation features of tissues

Abstract

Funding

Keywords

Access to Document

Fingerprint

Cite this