Maternal iron supplementation in pregnancy and asthma in the offspring: Follow-up of a randomised trial in Finland

Seif O. Shaheen*, Mika Gissler, Mika Gissler, Graham Devereux, Maijaliisa Erkkola, Tarja I. Kinnunen, Harry Mcardle, Aziz Sheikh, Elina Hemminki, Bright I. Nwaru, Bright I. Nwaru, Bright I. Nwaru, Bright I. Nwaru

*Corresponding author for this work

Research output: Contribution to journalLetterpeer-review

7 Citations (Scopus)



Evidence for the hypothesis that prenatal nutrition may influence the risk of childhood respiratory and atopic disorders has strengthened in recent years. For example, randomised controlled trials (RCTs) have suggested that maternal supplementation with vitamin D or fish oil in pregnancy could prevent early childhood wheezing and asthma in the offspring [1, 2]. Another nutrient of interest is iron. Animal experiments have implicated iron in fetal airway development [3]. In two UK population-based birth cohorts, using different approaches, we have found evidence suggesting that lower maternal iron levels in pregnancy may increase the risk of wheezing, atopy and lower lung function in the offspring [4–7]. However, the possibility that unmeasured or residual confounding might explain these observational findings cannot be ruled out. A study in the USA reported that maternal anaemia was associated with an increased risk of childhood asthma in offspring of mothers with asthma, but not in those whose mothers did not have asthma [8], although we did not confirm such effect modification [5].
Original languageEnglish
Article number1902335
JournalEuropean Respiratory Journal
Issue number6
Early online date4 Jun 2020
Publication statusPublished - Jun 2020

Bibliographical note

Support statement: This study was funded by the Tampere Tuberculosis Foundation. B.I. Nwaru acknowledges the support of the Knut and Alice Wallenberg Foundation, the Wallenberg Centre for Molecular and Translational Medicine, and the VBG Group Herman Krefting Foundation on Asthma and Allergy. A. Sheikh is supported by the Asthma UK Centre for Applied Research. Ethics approval was obtained from the Finnish Institute for Health and Welfare. Funding information for this article has been deposited with the Crossref Funder Registry.




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