Metabolic changes in hypertrophic cardiomyopathies: Scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

Jolanda van der Velden; Carlo Gabriele Tocchetti; Gilda Varricchi; Anna Bianco; Vasco Sequeira; Denise Hilfiker-Kleiner; Nazha Hamdani; Adelino Leite-Moreira; Manuel Mayr; Ines Falcão-Pires; Thomas Thum; Dana K Dawson; Jean-Luc Balligand; Stephane Heymans

doi:10.1093/cvr/cvy147

Metabolic changes in hypertrophic cardiomyopathies: Scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

Jolanda van der Velden
, Carlo Gabriele Tocchetti
, Gilda Varricchi
, Anna Bianco
, Vasco Sequeira
, Denise Hilfiker-Kleiner
, Nazha Hamdani
, Adelino Leite-Moreira
, Manuel Mayr
, Ines Falcão-Pires
, Thomas Thum
, Dana K Dawson
, Jean-Luc Balligand
, Stephane Heymans

Applied Medicine

Netherlands Heart Institute, Utrecht, The Netherlands.
University of Naples Federico II
Maastricht University Medical Center
Vrije University Medical Center
Hannover Medical School
Ruhr University Bochum
University of Porto
UNIVERSITY OF LONDON
Institut de Recherche Experimentale et Clinique (IREC)
University of Leuven, Leuven
Université catholique de Louvain
Cliniques Universitaires St Luc

Research output: Contribution to journal › Article › peer-review

94 Citations (Scopus)

11 Downloads (Pure)

Abstract

Disturbed metabolism as a consequence of obesity and diabetes may cause cardiac diseases (recently highlighted in the CVR spotlight issue on Metabolic cardiomyopathies).1 In turn, the metabolism of the heart may also be disturbed in genetic and acquired forms of hypertrophic cardiac disease. Here, we provide an overview of recent insights on metabolic changes in genetic hypertrophic cardiomyopathy (HCM) and discuss several therapies which may be explored to target disturbed metabolism and prevent onset of cardiac hypertrophy.

Original language	English
Pages (from-to)	1273-1280
Number of pages	8
Journal	Cardiovascular Research
Volume	114
Issue number	10
Early online date	15 Jun 2018
DOIs	https://doi.org/10.1093/cvr/cvy147
Publication status	Published - 1 Aug 2018

Bibliographical note

JV is supported by the Netherlands Cardiovascular Research Initiative, an initiative with support of the Dutch Heart Foundation, CVON2014-40 DOSIS. SH has received funding from the European Union Commission’s Seventh Framework programme under grant agreement N° 305507 (HOMAGE), N° 602904 (FIBROTARGETS) and FP7-Health-2013- Innovations-1 N° 602156 (HECATOS). . We acknowledge the support from the Netherlands Cardiovascular Research Initiative, an initiative with support of the Dutch Heart Foundation, CVON2011-ARENA, CVON2016-Early HFPEF, and ShePREDICTS. This research is cofinanced as a PPP-allowance Research and Innovation by the Ministry of Economic Affairs within Top Sector Life sciences & Health. This research was co-funded by the C3 project “Vision Core Leuven” of the Leuven University

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Journal Article
hypertrophic cardiomyopathy
mutations
metabolism

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10.1093/cvr/cvy147Licence: CC BY-NC

Metabolic changes in hypertrophic cardiomyopathies
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact [email protected]
Final published version, 437 KBLicence: CC BY-NC

Cite this

van der Velden, J., Gabriele Tocchetti, C., Varricchi, G., Bianco, A., Sequeira, V., Hilfiker-Kleiner, D., Hamdani, N., Leite-Moreira, A., Mayr, M., Falcão-Pires, I., Thum, T., Dawson, D. K., Balligand, J.-L., & Heymans, S. (2018). Metabolic changes in hypertrophic cardiomyopathies: Scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. Cardiovascular Research, 114(10), 1273-1280. https://doi.org/10.1093/cvr/cvy147

Metabolic changes in hypertrophic cardiomyopathies: Scientific update from the Working Group of Myocardial Function of the European Society of Cardiology. / van der Velden, Jolanda; Gabriele Tocchetti, Carlo; Varricchi, Gilda et al.
In: Cardiovascular Research, Vol. 114, No. 10, 01.08.2018, p. 1273-1280.

Research output: Contribution to journal › Article › peer-review

van der Velden, J, Gabriele Tocchetti, C, Varricchi, G, Bianco, A, Sequeira, V, Hilfiker-Kleiner, D, Hamdani, N, Leite-Moreira, A, Mayr, M, Falcão-Pires, I, Thum, T, Dawson, DK, Balligand, J-L & Heymans, S 2018, 'Metabolic changes in hypertrophic cardiomyopathies: Scientific update from the Working Group of Myocardial Function of the European Society of Cardiology', Cardiovascular Research, vol. 114, no. 10, pp. 1273-1280. https://doi.org/10.1093/cvr/cvy147

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abstract = "Disturbed metabolism as a consequence of obesity and diabetes may cause cardiac diseases (recently highlighted in the CVR spotlight issue on Metabolic cardiomyopathies).1 In turn, the metabolism of the heart may also be disturbed in genetic and acquired forms of hypertrophic cardiac disease. Here, we provide an overview of recent insights on metabolic changes in genetic hypertrophic cardiomyopathy (HCM) and discuss several therapies which may be explored to target disturbed metabolism and prevent onset of cardiac hypertrophy.",

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AU - Hilfiker-Kleiner, Denise

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Metabolic changes in hypertrophic cardiomyopathies: Scientific update from the Working Group of Myocardial Function of the European Society of Cardiology

Abstract

Bibliographical note

UN SDGs

Keywords

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Cite this