Methodological and statistical issues of quality of life (QoL) and economic evaluation in cancer clinical trials: Report of a workshop

N. Neymark* (Corresponding Author), W. Kiebert, K. Torfs, L. Davies, P. Fayers, B. Hillner, R. Gelber, G. Guyatt, P. Kind, D. Machin, E. Nord, D. Osoba, D. Revicki, K. Schulman, K. Simpson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Citations (Scopus)


In recent years, quality of life (QoL) and economic evaluations have become increasingly important as additional outcome measures in cancer clinical trials. However, both fields of research are relatively new and in need of finding solutions to a substantial number of specific methodological problems. This paper reports on the proceedings of a symposium aimed at summarising and discussing some of the most contentious methodological and statistical issues in QoL and economic evaluations. In addition, possible solutions are indicated and the most pertinent areas of research are identified. Issues specific to QoL evaluations that are addressed include clinically meaningful changes in QoL scores; how to analyse QoL data and to handle missing and censored data and integration of length of life and QoL outcomes. Issues specific to economic evaluations are the advantages and disadvantages of various outcome measures; statistical methods to analyse economic data and choice of decision criteria and analytical perspective. How to perform QoL and economic evaluations in large and simple trials and whether the gap between QoL and utility measures can be bridged are also discussed.

Original languageEnglish
Pages (from-to)1317-1333
Number of pages17
JournalEuropean Journal of Cancer
Issue number9
Publication statusPublished - Aug 1998

Bibliographical note

Financial support was received mainly through two EU projects: DG V, SOC 94 201948 05F01 ('Economic evaluation of cancer treatment in Europe: exchange of research experience and education for practitioners in oncology') and DG V,
SOC 94 203301 05F01 (`Evaluation of factors aVecting the QoL of cancer patients and training of cancer treatment professionals in QoL issues').


  • Cancer
  • Costs
  • Economic evaluation
  • Quality of life


Dive into the research topics of 'Methodological and statistical issues of quality of life (QoL) and economic evaluation in cancer clinical trials: Report of a workshop'. Together they form a unique fingerprint.

Cite this