Modulating the early-life gut microbiota using pro-, pre-, and synbiotics to improve gut health, child development, and growth

Benjamin Momo Kadia; Mary Iwaret Otiti; Anouschka S Ramsteijn; Doudou Sow; Babacar Faye; Claire Heffernan; Lindsay J Hall; Joanne P Webster; Alan W Walker; Stephen Allen

doi:10.1093/nutrit/nuad050

Modulating the early-life gut microbiota using pro-, pre-, and synbiotics to improve gut health, child development, and growth

Benjamin Momo Kadia^* (Corresponding Author)
, Mary Iwaret Otiti
, Anouschka S Ramsteijn
, Doudou Sow
, Babacar Faye
, Claire Heffernan
, Lindsay J Hall
, Joanne P Webster
, Alan W Walker
, Stephen Allen

^*Corresponding author for this work

The Rowett Institute of Nutrition and Health

Liverpool School of Tropical Medicine
London International Development Centre
Technical University of Munich
University of London
Université Gaston Berger
Université Cheikh Anta Diop de Dakar
University of East Anglia
Quadram Institute Bioscience

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

8 Downloads (Pure)

Abstract

In children exposed to poor hygiene and sanitation, invasion of the gut by pathogenic microbes can result in a subclinical enteropathy termed "environmental enteric dysfunction" (EED) that contributes to undernutrition, growth faltering, and impaired organ development. EED may already be present by age 6-12 weeks; therefore, interventions that can be started early in life, and used alongside breastfeeding, are needed to prevent or ameliorate EED. A healthy gut microbiota is critical for intestinal development and repair, nutrient digestion and absorption, and resisting colonization or overgrowth by pathogens. However, its development can be impaired by several environmental factors. Dietary supplementation with pro-, pre-, or synbiotics may be a pragmatic and safe means of building the resilience of the developing gut microbiota against adverse environmental factors, thereby preventing EED.

Original language	English
Pages (from-to)	244-247
Number of pages	4
Journal	Nutrition Reviews
Volume	82
Issue number	2
Early online date	11 May 2023
DOIs	https://doi.org/10.1093/nutrit/nuad050
Publication status	Published - Feb 2024

Bibliographical note

Funding. This paper was conceived by the research teams engaged in the Gut Health workstream of the Action Against Stunting Hub (https://actionagainststunting.org/) funded by the United Kingdom Research and Innovation Global Challenges Research Fund (grant number: MR/S01313X/1) and the PRObiotics and SYNbiotics supplementation in infants in Kenya (PROSYNK) study (https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=9798) funded by the Children’s Investment Fund Foundation (grant number: R-1806–02780). A.W.W. also receives core funding support from the Scottish Government’s Rural and Environment Science and Analytical Services Division (RESAS; no grant number).

Data Availability Statement

The following Supporting Information is available through the online version of this article at the publisher’s website: Table S1 Interventions that have been trialed previously to prevent or ameliorate environmental enteric dysfunction.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 2 Zero Hunger

Keywords

environmental enteric dysfunction
gut microbiota
gut pathogens
probiotics
prebiotics
synbiotics

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10.1093/nutrit/nuad050Licence: CC BY

Kadia_etal_NR_Modulating_The_Early_VoR
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/ licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
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Cite this

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title = "Modulating the early-life gut microbiota using pro-, pre-, and synbiotics to improve gut health, child development, and growth",

abstract = "In children exposed to poor hygiene and sanitation, invasion of the gut by pathogenic microbes can result in a subclinical enteropathy termed {"}environmental enteric dysfunction{"} (EED) that contributes to undernutrition, growth faltering, and impaired organ development. EED may already be present by age 6-12 weeks; therefore, interventions that can be started early in life, and used alongside breastfeeding, are needed to prevent or ameliorate EED. A healthy gut microbiota is critical for intestinal development and repair, nutrient digestion and absorption, and resisting colonization or overgrowth by pathogens. However, its development can be impaired by several environmental factors. Dietary supplementation with pro-, pre-, or synbiotics may be a pragmatic and safe means of building the resilience of the developing gut microbiota against adverse environmental factors, thereby preventing EED.",

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note = "Funding. This paper was conceived by the research teams engaged in the Gut Health workstream of the Action Against Stunting Hub (https://actionagainststunting.org/) funded by the United Kingdom Research and Innovation Global Challenges Research Fund (grant number: MR/S01313X/1) and the PRObiotics and SYNbiotics supplementation in infants in Kenya (PROSYNK) study (https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=9798) funded by the Children{\textquoteright}s Investment Fund Foundation (grant number: R-1806{\textendash}02780). A.W.W. also receives core funding support from the Scottish Government{\textquoteright}s Rural and Environment Science and Analytical Services Division (RESAS; no grant number).",

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AU - Faye, Babacar

AU - Heffernan, Claire

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AU - Webster, Joanne P

AU - Walker, Alan W

AU - Allen, Stephen

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Modulating the early-life gut microbiota using pro-, pre-, and synbiotics to improve gut health, child development, and growth

Abstract

Bibliographical note

Data Availability Statement

UN SDGs

Keywords

Access to Document

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