Morbidity After Takotsubo Syndrome: A Report From the Scottish Takotsubo Registry

Amelia Elizabeth Rudd; Graham W. Horgan; Jim McGowan; Arvind Sood; Ross McGeoch; John Irving; Jonathan Watt; Stephen J. Leslie; Mark C. Petrie; Chim C Lang; Nicholas L Mills; David E Newby; Dana Dawson

doi:10.7326/ANNALS-24-01770

Morbidity After Takotsubo Syndrome: A Report From the Scottish Takotsubo Registry

Amelia Elizabeth Rudd
, Graham W. Horgan
, Jim McGowan
, Arvind Sood
, Ross McGeoch
, John Irving
, Jonathan Watt
, Stephen J. Leslie
, Mark C. Petrie
, Chim C Lang
, Nicholas L Mills
, David E Newby
, Dana Dawson^* (Corresponding Author)

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Background: Takotsubo syndrome is characterized by transient left ventricular dysfunction, often precipitated by intense emotional or physical stress. Although its clinical presentation is like that of acute myocardial infarction, there is no culprit or obstructive coronary artery disease on coronary angiography. After the acute phase, the left ventricular ejection fraction fully recovers (1). Despite this, several registries have reported reduced long-term survival after an episode of acute takotsubo syndrome (2–4). The Scottish Takotsubo Registry showed this reduced long-term survival to be specifically attributable to cardiovascular mortality (4). However, the extent and causes of subsequent illness after recovery from an episode of takotsubo syndrome are unknown.
Objective: To explore the incidence and causes of all subsequent hospital readmissions affecting patients with takotsubo syndrome.

Original language	English
Pages (from-to)	754-757
Number of pages	4
Journal	Annals of Internal Medicine
Volume	178
Early online date	25 Mar 2025
DOIs	https://doi.org/10.7326/ANNALS-24-01770
Publication status	Published - May 2025

Bibliographical note

We are grateful to all clinical cardiology colleagues in Scotland who continue to collaborate on takotsubo syndrome research and to the patients. The authors would like to acknowledge the support of the eDRIS Team (Public Health Scotland), in particular to Ms Lizzie Nicholson, Research Coordinator, for their involvement in obtaining approvals, provisioning and linking data, the use of the secure analytical platform within the National Safe Haven, to Dr Ken Lee for curating the clinical demographics of the High-STEACS cohort and to Chris Tuck for managing the approvals to provide the High-STEACS data to the STARR Safe Haven platform.

Data Availability Statement

Reproducible Research Statement: Study protocol: Available fromMs. Rudd (e-mail, [email protected]). Statistical code: Availablefrom Dr. Horgan (e-mail, [email protected]). Data set: Availablefrom Public Health Scotland (e-mail, [email protected])

Funding

This study was funded by the Chief Scientist Office, British Heart Foundation, Chief Scientist Office Scotland Aware CGA-16-4 and the BHF Research Training Fellowship (FS/RTF/20/30009, for Mrs Amelia Rudd), both to D. Dawson. NLM is supported by a Chair Award, Programme Grant, and Research Excellence Award (CH/F/21/90010, RG/20/10/34966, RE/24/130012) from the British Heart Foundation. DEN is supported by the British Heart Foundation (CH/09/002, RG/F/22/110093, RE/24/130012).

Funders	Funder number
Chief Scientist Office of the Scottish Government	CGA-16-4
British Heart Foundation	FS/RTF/20/30009, CH/F/21/90010, RG/20/10/34966, RE/24/130012, CH/09/002, RG/F/22/110093, RE/24/130012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

arrhythmia
confidence intervals
hazard ratio
heart
morbidity
myocardial infarction
population statistics
population statistics Prevention, policy, and public health
psychiatry and mental health
research reporting guidelines
scientists

Access to Document

10.7326/ANNALS-24-01770Licence: Unspecified

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This manuscript has been made open access under a Creative Commons Attribution (CC BY) licence under the terms of the University of Aberdeen Research Publications Policy. https://creativecommons.org/licenses/by/4.0/
Accepted author manuscript, 422 KBLicence: CC BY

Cite this

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title = "Morbidity After Takotsubo Syndrome: A Report From the Scottish Takotsubo Registry",

abstract = "Background: Takotsubo syndrome is characterized by transient left ventricular dysfunction, often precipitated by intense emotional or physical stress. Although its clinical presentation is like that of acute myocardial infarction, there is no culprit or obstructive coronary artery disease on coronary angiography. After the acute phase, the left ventricular ejection fraction fully recovers (1). Despite this, several registries have reported reduced long-term survival after an episode of acute takotsubo syndrome (2–4). The Scottish Takotsubo Registry showed this reduced long-term survival to be specifically attributable to cardiovascular mortality (4). However, the extent and causes of subsequent illness after recovery from an episode of takotsubo syndrome are unknown. Objective: To explore the incidence and causes of all subsequent hospital readmissions affecting patients with takotsubo syndrome. ",

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note = "We are grateful to all clinical cardiology colleagues in Scotland who continue to collaborate on takotsubo syndrome research and to the patients. The authors would like to acknowledge the support of the eDRIS Team (Public Health Scotland), in particular to Ms Lizzie Nicholson, Research Coordinator, for their involvement in obtaining approvals, provisioning and linking data, the use of the secure analytical platform within the National Safe Haven, to Dr Ken Lee for curating the clinical demographics of the High-STEACS cohort and to Chris Tuck for managing the approvals to provide the High-STEACS data to the STARR Safe Haven platform. ",

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doi = "10.7326/ANNALS-24-01770",

language = "English",

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pages = "754--757",

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AU - Rudd, Amelia Elizabeth

AU - Horgan, Graham W.

AU - McGowan, Jim

AU - Sood, Arvind

AU - McGeoch, Ross

AU - Irving, John

AU - Watt, Jonathan

AU - Leslie, Stephen J.

AU - Petrie, Mark C.

AU - Lang, Chim C

AU - Mills, Nicholas L

AU - Newby, David E

AU - Dawson, Dana

N1 - We are grateful to all clinical cardiology colleagues in Scotland who continue to collaborate on takotsubo syndrome research and to the patients. The authors would like to acknowledge the support of the eDRIS Team (Public Health Scotland), in particular to Ms Lizzie Nicholson, Research Coordinator, for their involvement in obtaining approvals, provisioning and linking data, the use of the secure analytical platform within the National Safe Haven, to Dr Ken Lee for curating the clinical demographics of the High-STEACS cohort and to Chris Tuck for managing the approvals to provide the High-STEACS data to the STARR Safe Haven platform.

PY - 2025/5

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N2 - Background: Takotsubo syndrome is characterized by transient left ventricular dysfunction, often precipitated by intense emotional or physical stress. Although its clinical presentation is like that of acute myocardial infarction, there is no culprit or obstructive coronary artery disease on coronary angiography. After the acute phase, the left ventricular ejection fraction fully recovers (1). Despite this, several registries have reported reduced long-term survival after an episode of acute takotsubo syndrome (2–4). The Scottish Takotsubo Registry showed this reduced long-term survival to be specifically attributable to cardiovascular mortality (4). However, the extent and causes of subsequent illness after recovery from an episode of takotsubo syndrome are unknown. Objective: To explore the incidence and causes of all subsequent hospital readmissions affecting patients with takotsubo syndrome.

AB - Background: Takotsubo syndrome is characterized by transient left ventricular dysfunction, often precipitated by intense emotional or physical stress. Although its clinical presentation is like that of acute myocardial infarction, there is no culprit or obstructive coronary artery disease on coronary angiography. After the acute phase, the left ventricular ejection fraction fully recovers (1). Despite this, several registries have reported reduced long-term survival after an episode of acute takotsubo syndrome (2–4). The Scottish Takotsubo Registry showed this reduced long-term survival to be specifically attributable to cardiovascular mortality (4). However, the extent and causes of subsequent illness after recovery from an episode of takotsubo syndrome are unknown. Objective: To explore the incidence and causes of all subsequent hospital readmissions affecting patients with takotsubo syndrome.

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KW - confidence intervals

KW - hazard ratio

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KW - morbidity

KW - myocardial infarction

KW - population statistics

KW - population statistics Prevention, policy, and public health

KW - psychiatry and mental health

KW - research reporting guidelines

KW - scientists

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DO - 10.7326/ANNALS-24-01770

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JO - Annals of Internal Medicine

JF - Annals of Internal Medicine

ER -

Morbidity After Takotsubo Syndrome: A Report From the Scottish Takotsubo Registry

Abstract

Bibliographical note

Data Availability Statement

Funding

UN SDGs

Keywords

Access to Document

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Cite this