Neonatal examination and screening trial (NEST): a randomised, controlled, switchback trial of alternative policies for low risk infants

C M A Glazener, C R Ramsay, M K Campbell, P Booth, P Duffty, D J Lloyd, A McDonald, J A Reid

Research output: Contribution to journalArticle

34 Citations (Scopus)


Objective To evaluate the effectiveness of one rather than two hospital neonatal examinations in detection of abnormalities.

Design Randomised controlled switchback trial.

Setting Postnatal wards in a teaching hospital in north east Scotland.

Participants All infants delivered at the hospital between March 1993 and February 1995.

Intervention A policy of one neonatal screening examination compared with a policy of two.

Main outcome measures Congenital conditions diagnosed in hospital; results of community health assessments at 8 weeks and 8 months; outpatient referrals; inpatient admissions; use of general practioner services; focused analysis of outcomes for suspected hip and heart abnormalities.

Results 4835 babies were allocated to receive one screening examination (one screen policy) and 4877 to receive two (two screen policy). More congenital conditions were suspected at discharge among babies examined twice (9.9 v 8.3 diagnoses per 100 babies; 95% confidence interval for difference 0.3 to 2.7). There was no no overall significant difference between the groups in use of community, outpatient, or inpatient resources or in health care received. Although more babies who were examined twice attended orthopaedic outpatient clinics (340 (7%) v 289 (6%)), particularly for suspected congenital dislocation of the hip (176 (3.6/100 babies) v 137 (2.8/100 babies); difference - 0.8; - 1.5 to 0.1), there was no significant difference in the number of babies who required active management (12 (0.2%) v 15 (0.3%)).

Conclusions Despite more suspected abnormalities, there was no evidence of net health gain from a policy of two hospital neonatal examinations, Adoption of a single examination policy would save resources both during the postnatal hospital stay and through fewer outpatient consultations.

Original languageEnglish
Pages (from-to)627-631
Number of pages5
JournalBritish Medical Journal
Issue number7184
Publication statusPublished - 6 Mar 1999


  • congenital dislocation
  • hip


Dive into the research topics of 'Neonatal examination and screening trial (NEST): a randomised, controlled, switchback trial of alternative policies for low risk infants'. Together they form a unique fingerprint.

Cite this