Nitrate and nitrite in biology, nutrition and therapeutics

Jon O. Lundberg; Mark T. Gladwin; Amrita Ahluwalia; Nigel Benjamin; Nathan S. Bryan; Anthony Butler; Pedro Cabrales; Angela Fago; Martin Feelisch; Peter C. Ford; Andrew Freeman; Michael Frenneaux; Joel Friedman; Malte Kelm; Christopher G. Kevil; Daniel B. Kim-Shapiro; Andrey V. Kozlov; Jack R.  Lancaster; David J. Lefer; Kenneth McColl; Kenneth McCurry; Rakesh P. Patel; Joel Petersson; Tienush Rassaf; Valentin P. Reutov; George B. Richter-Addo; Alan Schechter; Sruti Shiva; Koichiro Tsuchiya; Ernst E. van Faassen; Andrew J. Webb; Brian S. Zuckerbraun; Jay L. Zweier; Eddie Weitzberg

doi:10.1038/nchembio.260

Nitrate and nitrite in biology, nutrition and therapeutics

Jon O. Lundberg
, Mark T. Gladwin
, Amrita Ahluwalia
, Nigel Benjamin
, Nathan S. Bryan
, Anthony Butler
, Pedro Cabrales
, Angela Fago
, Martin Feelisch
, Peter C. Ford
, Andrew Freeman
, Michael Frenneaux
, Joel Friedman
, Malte Kelm
, Christopher G. Kevil
, Daniel B. Kim-Shapiro
, Andrey V. Kozlov
, Jack R. Lancaster
, David J. Lefer
, Kenneth McColl

Kenneth McCurry, Rakesh P. Patel, Joel Petersson, Tienush Rassaf, Valentin P. Reutov, George B. Richter-Addo, Alan Schechter, Sruti Shiva, Koichiro Tsuchiya, Ernst E. van Faassen, Andrew J. Webb, Brian S. Zuckerbraun, Jay L. Zweier, Eddie Weitzberg

Applied Medicine

Barts & The London School of Medicine & Dentistry
Peninsula Medical School Universities of Exeter and Plymouth
University of St Andrews
Albert Einstein College of Medicine
Heinrich Heine University Düsseldorf
Ludwig Boltzmann Inst Expt & Clin Traumatol
University of Alabama
University of Glasgow
NIH
Utrecht University
University of Warwick
Wake Forest University
Ohio State University
Karolinska Institutet
Tokushima University
University of Pittsburgh
University of Oklahoma
Russian Academy of Sciences
Uppsala University
Emory University
Louisiana State University
University of California at Santa Barbara
Aarhus University
University of California at San Diego
University of Texas Health Science Center at Houston

Research output: Contribution to journal › Editorial › peer-review

540 Citations (Scopus)

Abstract

Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as an important mediator of blood flow regulation, cell signaling, energetics and tissue responses to hypoxia. The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm.

Original language	English
Pages (from-to)	865-869
Number of pages	5
Journal	Nature Chemical Biology
Volume	5
Issue number	12
DOIs	https://doi.org/10.1038/nchembio.260
Publication status	Published - Dec 2009

Keywords

ischemia-reperfusion injury
dietary nitrate
reductase-activity
blood-pressure
oxide production
humans
deoxyhemoglobin
hemoglobin
physiology
tolerance

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10.1038/nchembio.260

Cite this

Lundberg, J. O., Gladwin, M. T., Ahluwalia, A., Benjamin, N., Bryan, N. S., Butler, A., Cabrales, P., Fago, A., Feelisch, M., Ford, P. C., Freeman, A., Frenneaux, M., Friedman, J., Kelm, M., Kevil, C. G., Kim-Shapiro, D. B., Kozlov, A. V., Lancaster, J. R., Lefer, D. J., ... Weitzberg, E. (2009). Nitrate and nitrite in biology, nutrition and therapeutics. Nature Chemical Biology, 5(12), 865-869. https://doi.org/10.1038/nchembio.260

Lundberg, JO, Gladwin, MT, Ahluwalia, A, Benjamin, N, Bryan, NS, Butler, A, Cabrales, P, Fago, A, Feelisch, M, Ford, PC, Freeman, A, Frenneaux, M, Friedman, J, Kelm, M, Kevil, CG, Kim-Shapiro, DB, Kozlov, AV, Lancaster, JR, Lefer, DJ, McColl, K, McCurry, K, Patel, RP, Petersson, J, Rassaf, T, Reutov, VP, Richter-Addo, GB, Schechter, A, Shiva, S, Tsuchiya, K, van Faassen, EE, Webb, AJ, Zuckerbraun, BS, Zweier, JL & Weitzberg, E 2009, 'Nitrate and nitrite in biology, nutrition and therapeutics', Nature Chemical Biology, vol. 5, no. 12, pp. 865-869. https://doi.org/10.1038/nchembio.260

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title = "Nitrate and nitrite in biology, nutrition and therapeutics",

abstract = "Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as an important mediator of blood flow regulation, cell signaling, energetics and tissue responses to hypoxia. The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm.",

keywords = "ischemia-reperfusion injury, dietary nitrate, reductase-activity, blood-pressure, oxide production, humans, deoxyhemoglobin, hemoglobin, physiology, tolerance",

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AU - Butler, Anthony

AU - Cabrales, Pedro

AU - Fago, Angela

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AU - Ford, Peter C.

AU - Freeman, Andrew

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AU - Kozlov, Andrey V.

AU - Lancaster, Jack R.

AU - Lefer, David J.

AU - McColl, Kenneth

AU - McCurry, Kenneth

AU - Patel, Rakesh P.

AU - Petersson, Joel

AU - Rassaf, Tienush

AU - Reutov, Valentin P.

AU - Richter-Addo, George B.

AU - Schechter, Alan

AU - Shiva, Sruti

AU - Tsuchiya, Koichiro

AU - van Faassen, Ernst E.

AU - Webb, Andrew J.

AU - Zuckerbraun, Brian S.

AU - Zweier, Jay L.

AU - Weitzberg, Eddie

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AB - Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as an important mediator of blood flow regulation, cell signaling, energetics and tissue responses to hypoxia. The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm.

KW - ischemia-reperfusion injury

KW - dietary nitrate

KW - reductase-activity

KW - blood-pressure

KW - oxide production

KW - humans

KW - deoxyhemoglobin

KW - hemoglobin

KW - physiology

KW - tolerance

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SP - 865

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JO - Nature Chemical Biology

JF - Nature Chemical Biology

IS - 12

ER -

Nitrate and nitrite in biology, nutrition and therapeutics

Abstract

Keywords

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