Nitric oxide in a nutshell: Genetics, physiology and pathology

H. F. Galley; N. R. Webster

doi:10.1016/S0953-7112(98)80057-4

Nitric oxide in a nutshell: Genetics, physiology and pathology

H. F. Galley^*
, N. R. Webster

^*Corresponding author for this work

Applied Medicine

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The idea that nitric oxide gas, known from undergraduate chemistry to be a toxic by-product of car exhausts and cigarettes, and the scourge of anaesthetists as a contaminant of nitrous oxide cylinders, could be a biological mediator, was unthinkable 15 years ago. However, in 1987, it was shown that the elusive endothelium-derived relaxing factor was indeed nitric oxide, produced by mammalian cells, with roles in blood pressure regulation, neurotransmission, immunity and cardiovascular function.

Original language	English
Pages (from-to)	209-213
Number of pages	5
Journal	Current Anaesthesia and Critical Care
Volume	9
Issue number	4
DOIs	https://doi.org/10.1016/S0953-7112(98)80057-4
Publication status	Published - 1 Aug 1998

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abstract = "The idea that nitric oxide gas, known from undergraduate chemistry to be a toxic by-product of car exhausts and cigarettes, and the scourge of anaesthetists as a contaminant of nitrous oxide cylinders, could be a biological mediator, was unthinkable 15 years ago. However, in 1987, it was shown that the elusive endothelium-derived relaxing factor was indeed nitric oxide, produced by mammalian cells, with roles in blood pressure regulation, neurotransmission, immunity and cardiovascular function.",

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AB - The idea that nitric oxide gas, known from undergraduate chemistry to be a toxic by-product of car exhausts and cigarettes, and the scourge of anaesthetists as a contaminant of nitrous oxide cylinders, could be a biological mediator, was unthinkable 15 years ago. However, in 1987, it was shown that the elusive endothelium-derived relaxing factor was indeed nitric oxide, produced by mammalian cells, with roles in blood pressure regulation, neurotransmission, immunity and cardiovascular function.

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Nitric oxide in a nutshell: Genetics, physiology and pathology

Abstract

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