No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke

M J  MacLeod; M T  Dahiyat; A  Cumming; D  Meiklejohn; D  Shaw; D  St Clair

No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke

M J MacLeod
, M T Dahiyat
, A Cumming
, D Meiklejohn
, D Shaw
, D St Clair

Research output: Contribution to journal › Article

Abstract

Endothelial nitric oxide synthase (NOS3) gene has been shown to modulate the degree of cerebral ischemia following stroke in animal models and is thus a candidate genetic risk factor for stroke, We compared 265 ischemic stroke cases with 293 controls and found no difference in distribution of the common structural variant Glu/Asp in codon 298 of exon 7 in the NOS3 gene. Our data do not support the hypothesis that NOS3 is a genetic risk factor for stroke.

Original language	English
Pages (from-to)	418-420
Number of pages	3
Journal	Neurology
Volume	53
Publication status	Published - 1999

Keywords

NITRIC-OXIDE SYNTHASE
RAT MODEL
DISEASE

Cite this

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title = "No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke",

abstract = "Endothelial nitric oxide synthase (NOS3) gene has been shown to modulate the degree of cerebral ischemia following stroke in animal models and is thus a candidate genetic risk factor for stroke, We compared 265 ischemic stroke cases with 293 controls and found no difference in distribution of the common structural variant Glu/Asp in codon 298 of exon 7 in the NOS3 gene. Our data do not support the hypothesis that NOS3 is a genetic risk factor for stroke.",

keywords = "NITRIC-OXIDE SYNTHASE, RAT MODEL, DISEASE",

author = "MacLeod, \{M J\} and Dahiyat, \{M T\} and A Cumming and D Meiklejohn and D Shaw and \{St Clair\}, D",

year = "1999",

language = "English",

volume = "53",

pages = "418--420",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

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TY - JOUR

T1 - No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke

AU - MacLeod, M J

AU - Dahiyat, M T

AU - Cumming, A

AU - Meiklejohn, D

AU - Shaw, D

AU - St Clair, D

PY - 1999

Y1 - 1999

N2 - Endothelial nitric oxide synthase (NOS3) gene has been shown to modulate the degree of cerebral ischemia following stroke in animal models and is thus a candidate genetic risk factor for stroke, We compared 265 ischemic stroke cases with 293 controls and found no difference in distribution of the common structural variant Glu/Asp in codon 298 of exon 7 in the NOS3 gene. Our data do not support the hypothesis that NOS3 is a genetic risk factor for stroke.

AB - Endothelial nitric oxide synthase (NOS3) gene has been shown to modulate the degree of cerebral ischemia following stroke in animal models and is thus a candidate genetic risk factor for stroke, We compared 265 ischemic stroke cases with 293 controls and found no difference in distribution of the common structural variant Glu/Asp in codon 298 of exon 7 in the NOS3 gene. Our data do not support the hypothesis that NOS3 is a genetic risk factor for stroke.

KW - NITRIC-OXIDE SYNTHASE

KW - RAT MODEL

KW - DISEASE

M3 - Article

SN - 0028-3878

VL - 53

SP - 418

EP - 420

JO - Neurology

JF - Neurology

ER -

No association between Glu/Asp polymorphism of NOS3 gene and ischemic stroke

Abstract

Keywords

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