Nonpharmacological interventions to treat physical frailty and sarcopenia in older patients: a systematic overview - the SENATOR Project ONTOP Series

Isabel Lozano-Montoya; Andrea Correa-Pérez; Iosief Abraha; Roy L Soiza; Antonio Cherubini; Denis O'Mahony; Alfonso J Cruz-Jentoft

doi:10.2147/CIA.S132496

Nonpharmacological interventions to treat physical frailty and sarcopenia in older patients: a systematic overview - the SENATOR Project ONTOP Series

Isabel Lozano-Montoya, Andrea Correa-Pérez, Iosief Abraha, Roy L Soiza, Antonio Cherubini, Denis O'Mahony, Alfonso J Cruz-Jentoft

Health Services Research Unit (HSRU)

Research output: Contribution to journal › Review article › peer-review

86 Citations (Scopus)

9 Downloads (Pure)

Abstract

BACKGROUND: Physical frailty (PF) and sarcopenia are predictors of negative health outcomes such as falls, disability, hospitalization, and death. Some systematic reviews (SRs) have been published on different nonpharmacological treatments of frailty and sarcopenia using heterogeneous definitions of them.

OBJECTIVE: To critically appraise the evidence from SRs of the primary studies on nonpharmacological interventions to treat PF (defined by Fried's frailty phenotype) and sarcopenia (defined by the EWGSOP) in older patients.

DESIGN: Overview of SRs and meta-analysis of comparative studies.

DATA SOURCES: PubMed, Cochrane Database of Systematic Reviews, EMBASE, and CINAHL were searched in October 2015.

ELIGIBILITY CRITERIA FOR SELECTING STUDIES: SRs that included at least one comparative study evaluating any nonpharmacological intervention to treat PF or sarcopenia in older patients in any health care setting. Any primary study described in these SRs with experimental design was included.

DATA EXTRACTION AND MANAGEMENT: Two reviewers independently screened titles, abstracts, and full-texts of articles. Quality assessment was carried out by using criteria from the Cochrane Collaboration and the GRADE working group.

RESULTS: Ten SRs with 5 primary studies satisfied the inclusion criteria. The most frequent interventions in the included studies were physical exercise (4) and nutritional supplementation (2). Muscle strength (MS; except for one study in a frail population) and physical performance (PP; except for another study in a frail population) improved with exercise and amino acid supplementation in frail and sarcopenic old adults. Falls and activities of daily living were assessed in two studies with opposite results. The overall quality of the evidence was low.

CONCLUSION: This overview of SRs highlights the importance of exercise interventions with or without nutritional supplementation to improve the PP in community-dwelling patients aged >65 years with PF and sarcopenia. MS improved with multidisciplinary treatment and exercise interventions in this population.

Original language	English
Pages (from-to)	721-740
Number of pages	20
Journal	Clinical interventions in aging
Volume	12
DOIs	https://doi.org/10.2147/CIA.S132496
Publication status	Published - 24 Apr 2017

Bibliographical note

The authors thank the following panel members who participated in the Delphi process to identify relevant outcomes: Hubert Blain, Andrea Corsonello, Giuseppina
Dell’aquila, Adalsteinn Gudmundsson, Gunnar Akner, Mirko Petrovic, Regina Roller-Wirnsberger, Fabio Salvi, and Fabiana Trotta. The research leading to these results has been funded by the European Union Seventh Framework Programme (FP7/2007–2013) under grant agreement No 305930 (SENATOR).

Keywords

Aged
Dietary Supplements
Exercise
Frail Elderly
Humans
Muscle Strength
Sarcopenia
Journal Article
Review

Access to Document

10.2147/CIA.S132496Licence: CC BY-NC

Nonpharmacological interventions to treat
© 2017 Lozano-Montoya et al. This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php)
Final published version, 927 KBLicence: CC BY-NC

Cite this

@article{a515946cc97e41f29520a50345730ffd,

title = "Nonpharmacological interventions to treat physical frailty and sarcopenia in older patients: a systematic overview - the SENATOR Project ONTOP Series",

abstract = "BACKGROUND: Physical frailty (PF) and sarcopenia are predictors of negative health outcomes such as falls, disability, hospitalization, and death. Some systematic reviews (SRs) have been published on different nonpharmacological treatments of frailty and sarcopenia using heterogeneous definitions of them.OBJECTIVE: To critically appraise the evidence from SRs of the primary studies on nonpharmacological interventions to treat PF (defined by Fried's frailty phenotype) and sarcopenia (defined by the EWGSOP) in older patients.DESIGN: Overview of SRs and meta-analysis of comparative studies.DATA SOURCES: PubMed, Cochrane Database of Systematic Reviews, EMBASE, and CINAHL were searched in October 2015.ELIGIBILITY CRITERIA FOR SELECTING STUDIES: SRs that included at least one comparative study evaluating any nonpharmacological intervention to treat PF or sarcopenia in older patients in any health care setting. Any primary study described in these SRs with experimental design was included.DATA EXTRACTION AND MANAGEMENT: Two reviewers independently screened titles, abstracts, and full-texts of articles. Quality assessment was carried out by using criteria from the Cochrane Collaboration and the GRADE working group.RESULTS: Ten SRs with 5 primary studies satisfied the inclusion criteria. The most frequent interventions in the included studies were physical exercise (4) and nutritional supplementation (2). Muscle strength (MS; except for one study in a frail population) and physical performance (PP; except for another study in a frail population) improved with exercise and amino acid supplementation in frail and sarcopenic old adults. Falls and activities of daily living were assessed in two studies with opposite results. The overall quality of the evidence was low.CONCLUSION: This overview of SRs highlights the importance of exercise interventions with or without nutritional supplementation to improve the PP in community-dwelling patients aged >65 years with PF and sarcopenia. MS improved with multidisciplinary treatment and exercise interventions in this population.",

keywords = "Aged, Dietary Supplements, Exercise, Frail Elderly, Humans, Muscle Strength, Sarcopenia, Journal Article, Review",

author = "Isabel Lozano-Montoya and Andrea Correa-P{\'e}rez and Iosief Abraha and Soiza, {Roy L} and Antonio Cherubini and Denis O'Mahony and Cruz-Jentoft, {Alfonso J}",

note = "The authors thank the following panel members who participated in the Delphi process to identify relevant outcomes: Hubert Blain, Andrea Corsonello, Giuseppina Dell{\textquoteright}aquila, Adalsteinn Gudmundsson, Gunnar Akner, Mirko Petrovic, Regina Roller-Wirnsberger, Fabio Salvi, and Fabiana Trotta. The research leading to these results has been funded by the European Union Seventh Framework Programme (FP7/2007–2013) under grant agreement No 305930 (SENATOR).",

year = "2017",

month = apr,

day = "24",

doi = "10.2147/CIA.S132496",

language = "English",

volume = "12",

pages = "721--740",

journal = "Clinical interventions in aging",

issn = "1176-9092",

publisher = "Dove Medical Press Ltd.",

}

TY - JOUR

T1 - Nonpharmacological interventions to treat physical frailty and sarcopenia in older patients

T2 - a systematic overview - the SENATOR Project ONTOP Series

AU - Lozano-Montoya, Isabel

AU - Correa-Pérez, Andrea

AU - Abraha, Iosief

AU - Soiza, Roy L

AU - Cherubini, Antonio

AU - O'Mahony, Denis

AU - Cruz-Jentoft, Alfonso J

N1 - The authors thank the following panel members who participated in the Delphi process to identify relevant outcomes: Hubert Blain, Andrea Corsonello, Giuseppina Dell’aquila, Adalsteinn Gudmundsson, Gunnar Akner, Mirko Petrovic, Regina Roller-Wirnsberger, Fabio Salvi, and Fabiana Trotta. The research leading to these results has been funded by the European Union Seventh Framework Programme (FP7/2007–2013) under grant agreement No 305930 (SENATOR).

PY - 2017/4/24

Y1 - 2017/4/24

N2 - BACKGROUND: Physical frailty (PF) and sarcopenia are predictors of negative health outcomes such as falls, disability, hospitalization, and death. Some systematic reviews (SRs) have been published on different nonpharmacological treatments of frailty and sarcopenia using heterogeneous definitions of them.OBJECTIVE: To critically appraise the evidence from SRs of the primary studies on nonpharmacological interventions to treat PF (defined by Fried's frailty phenotype) and sarcopenia (defined by the EWGSOP) in older patients.DESIGN: Overview of SRs and meta-analysis of comparative studies.DATA SOURCES: PubMed, Cochrane Database of Systematic Reviews, EMBASE, and CINAHL were searched in October 2015.ELIGIBILITY CRITERIA FOR SELECTING STUDIES: SRs that included at least one comparative study evaluating any nonpharmacological intervention to treat PF or sarcopenia in older patients in any health care setting. Any primary study described in these SRs with experimental design was included.DATA EXTRACTION AND MANAGEMENT: Two reviewers independently screened titles, abstracts, and full-texts of articles. Quality assessment was carried out by using criteria from the Cochrane Collaboration and the GRADE working group.RESULTS: Ten SRs with 5 primary studies satisfied the inclusion criteria. The most frequent interventions in the included studies were physical exercise (4) and nutritional supplementation (2). Muscle strength (MS; except for one study in a frail population) and physical performance (PP; except for another study in a frail population) improved with exercise and amino acid supplementation in frail and sarcopenic old adults. Falls and activities of daily living were assessed in two studies with opposite results. The overall quality of the evidence was low.CONCLUSION: This overview of SRs highlights the importance of exercise interventions with or without nutritional supplementation to improve the PP in community-dwelling patients aged >65 years with PF and sarcopenia. MS improved with multidisciplinary treatment and exercise interventions in this population.

AB - BACKGROUND: Physical frailty (PF) and sarcopenia are predictors of negative health outcomes such as falls, disability, hospitalization, and death. Some systematic reviews (SRs) have been published on different nonpharmacological treatments of frailty and sarcopenia using heterogeneous definitions of them.OBJECTIVE: To critically appraise the evidence from SRs of the primary studies on nonpharmacological interventions to treat PF (defined by Fried's frailty phenotype) and sarcopenia (defined by the EWGSOP) in older patients.DESIGN: Overview of SRs and meta-analysis of comparative studies.DATA SOURCES: PubMed, Cochrane Database of Systematic Reviews, EMBASE, and CINAHL were searched in October 2015.ELIGIBILITY CRITERIA FOR SELECTING STUDIES: SRs that included at least one comparative study evaluating any nonpharmacological intervention to treat PF or sarcopenia in older patients in any health care setting. Any primary study described in these SRs with experimental design was included.DATA EXTRACTION AND MANAGEMENT: Two reviewers independently screened titles, abstracts, and full-texts of articles. Quality assessment was carried out by using criteria from the Cochrane Collaboration and the GRADE working group.RESULTS: Ten SRs with 5 primary studies satisfied the inclusion criteria. The most frequent interventions in the included studies were physical exercise (4) and nutritional supplementation (2). Muscle strength (MS; except for one study in a frail population) and physical performance (PP; except for another study in a frail population) improved with exercise and amino acid supplementation in frail and sarcopenic old adults. Falls and activities of daily living were assessed in two studies with opposite results. The overall quality of the evidence was low.CONCLUSION: This overview of SRs highlights the importance of exercise interventions with or without nutritional supplementation to improve the PP in community-dwelling patients aged >65 years with PF and sarcopenia. MS improved with multidisciplinary treatment and exercise interventions in this population.

KW - Aged

KW - Dietary Supplements

KW - Exercise

KW - Frail Elderly

KW - Humans

KW - Muscle Strength

KW - Sarcopenia

KW - Journal Article

KW - Review

U2 - 10.2147/CIA.S132496

DO - 10.2147/CIA.S132496

M3 - Review article

C2 - 28490866

SN - 1176-9092

VL - 12

SP - 721

EP - 740

JO - Clinical interventions in aging

JF - Clinical interventions in aging

ER -

Nonpharmacological interventions to treat physical frailty and sarcopenia in older patients: a systematic overview - the SENATOR Project ONTOP Series

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this