Novel case of takotsubo cardiomyopathy following COVID-19 vaccination

Caitlin Stewart, David T. Gamble*, Dana Dawson

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


We present an unusual case of takotsubo cardiomyopathy (TTC) following administration of the second dose of the DNA ChadOX1 nCOV-19 (AZD122) vaccination. This woman in her early 50s presented to the emergency department 8 days following her vaccine with central chest pain. Initial investigations revealed a raised troponin and evolving T wave inversion on ECG. Acute coronary syndrome management was commenced. Further investigations revealed non-obstructive coronary arteries on coronary angiography and imaging revealed hypokinesia of the anterior and anterior-septal walls in the apex and midcavity level, myocardial oedema and no infarction, all in keeping with TTC. Given the large-scale roll out of vaccinations during the COVID-19 pandemic better understanding of potential adverse events is essential. This is the first case report of TTC following a second dose of the DNA ChadOX1 nCOV-19 (AZD122) vaccination.

Original languageEnglish
Article numbere247291
Number of pages4
JournalBMJ Case Reports
Issue number1
Early online date18 Jan 2022
Publication statusPublished - 18 Jan 2022

Bibliographical note

Acknowledgements Janaki Srinivasan for preparing the echocardiography images used in this report.
Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.


  • Cardiovascular medicine
  • COVID-19
  • Healthcare improvement and patient safety


Dive into the research topics of 'Novel case of takotsubo cardiomyopathy following COVID-19 vaccination'. Together they form a unique fingerprint.

Cite this