Nuclear Receptors: One Big Family

Research output: Chapter in Book/Report/Conference proceedingChapter

104 Citations (Scopus)


It is just over 20 years since the first steroid receptor cDNAs were cloned, a development that led to the birth of a superfamily of ligand activated transcription factors: the nuclear receptors. Natural ligands for nuclear receptors are generally lipophilic in nature and include steroid hormones, bile acids, fatty acids, thyroid hormones, certain vitamins and prostaglandins. These molecules act as sensors of the extracellular and intracellular environment and play crucial roles controlling development, differentiation, metabolic homeostasis, and reproduction. Since the original cloning experiments considerable progress has been made in our understanding of the structure, mechanisms of action and biology of this important family of proteins.
Original languageEnglish
Title of host publicationThe Nuclear Receptor Superfamily
Subtitle of host publicationMethods and Protocols
PublisherHumana Press
Number of pages16
ISBN (Electronic)978-1-60327-575-0
ISBN (Print)978-1-60327-574-3
Publication statusPublished - 2009


  • steroid hormones
  • glucocorticoid receptors
  • estrogen receptors
  • retinoic acid receptors
  • orphan receptors
  • gene regulation
  • phosphorylation
  • acetylation
  • sumoylation
  • hormone resistance


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