Abstract
Glioblastoma (GBM) is classified as Grade 4 by the WHO as the most aggressive primary brain cancer in adults. Hyaluronic acid (HA) is a major component in
the tissue extracellular matrix (ECM), modulating the growth, proliferation and invasion of cancer cells. Its level is 3 times or even higher in the brain tumours
(Grade 1-4) than that in the normal tissues [1]. However, the impact of HA on interstitial fluid (ISF) flow in all grades of brain tumours is not well understood. In this work, we aim to simulate ISF flow in different grades of brain tumours considering HA’s effect.
the tissue extracellular matrix (ECM), modulating the growth, proliferation and invasion of cancer cells. Its level is 3 times or even higher in the brain tumours
(Grade 1-4) than that in the normal tissues [1]. However, the impact of HA on interstitial fluid (ISF) flow in all grades of brain tumours is not well understood. In this work, we aim to simulate ISF flow in different grades of brain tumours considering HA’s effect.
| Original language | English |
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| Publication status | Published - Jul 2024 |
| Event | 29th Congress of the European Society of Biomechanics - Edinburgh, United Kingdom Duration: 2 Jul 2024 → 4 Jul 2024 https://esbiomech2024.org/ |
Conference
| Conference | 29th Congress of the European Society of Biomechanics |
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| Country/Territory | United Kingdom |
| City | Edinburgh |
| Period | 2/07/24 → 4/07/24 |
| Internet address |
