Abstract
Aims: We examined severe hospitalised hypoglycaemia (SHH) rates in people with type 1 and type 2 diabetes in Scotland during 2016–2022, stratifying by sociodemographics. Methods: Using the Scottish National diabetes register (SCI-Diabetes), we identified people with type 1 and type 2 diabetes alive anytime during 2016–2022. SHH events were determined through linkage to hospital admission and death registry data. We calculated annual SHH rates overall and by age, sex, and socioeconomic status. Summary estimates of time and stratum effects were obtained by fitting adjusted generalised additive models using R package mgcv. Results: Rates for those under 20 with type 1 diabetes reached their minimum at the 2020–2021 transition, 30% below the study period average. A gradual decline over time also occurred among 20–49-year-olds with type 1 diabetes. Overall, females had 15% higher rates than males with type 2 diabetes (rate ratio 1.15, 95% CI 1.08–1.22). People in the most versus least deprived quintile experienced 2.58 times higher rates (95% CI 2.27–2.93) in type 1 diabetes and 2.33 times higher (95% CI 2.08–2.62) in type 2 diabetes. Conclusions: Despite advances in care, SHH remains a significant problem in diabetes. Future efforts must address the large socioeconomic disparities in SHH risks.
| Original language | English |
|---|---|
| Article number | 111642 |
| Number of pages | 11 |
| Journal | DIABETES RESEARCH AND CLINICAL PRACTICE |
| Volume | 210 |
| Early online date | 4 Apr 2024 |
| DOIs | |
| Publication status | Published - Apr 2024 |
Bibliographical note
We are thankful for the contributions of people with diabetes, National Health Service staff, and organisations (the Scottish Care Information-Diabetes Development Team and Steering Group, the Scottish Diabetes Group, the Scottish Diabetes Survey Group, and the diabetes managed clinical networks) involved in providing data and setting up, maintaining, and overseeing collation of data for people with diabetes in Scotland. Data linkage was performed by colleagues at Public Health Scotland.Data Availability Statement
The SDRN-EPI team welcomes external collaborative research proposals that use the research data platform. SDRN-EPI are not data custodians and are not permitted to directly provision data externally. However, the component datasets can be obtained by data governance trained bone fide researchers through the Public Benefit and Privacy Panel for Health and Social Care. See https://www.informationgovernance.scot.nhs.uk/pbpphsc/ for how to apply.Funding
This work was supported by funding from the Innovative Medicines Initiative 2 Joint Undertaking (Agreement no. 777460; Project ref. H2020-GTI-IMI2-2016-10). We acknowledge the financial support of NHS Research Scotland (NRS), through Diabetes Network. The NHS Research Scotland Diabetes Network (formerly Scottish Diabetes Research Network) receives funding from the Chief Scientist Office of the Scottish Government. H.M.C. is supported by an endowed chair from the AXA Research Fund. S.H. was supported by EU IMI HypoRESOLVE programme.
| Funders | Funder number |
|---|---|
| Innovative Medicines Initiative 2 Joint Undertaking | 777460, H2020-GTI-IMI2-2016-10 |
| Chief Scientist Office |
Keywords
- Epidemiology
- Hospital admission
- Hypoglycaemia
- Population-based studies
- Type 1 diabetes
- Type 2 diabetes
Access to Document
- Berthon_etal_DRaCP_Ongoing_Burden_and_Recent_VOR
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