Opportunities and Challenges for Dietary Arsenic Intervention

Keeve E Nachman (Corresponding Author), Tracy Punshon, Laurie Rardin, Antonio J Signes-Pastor, Carolyn J Murray, Brian P Jackson, Mary Lou Guerinot, Thomas A Burke, Celia Y Chen, Habibul Ahsan, Maria Argos, Kathryn L Cottingham, Francesco Cubadda, Gary L Ginsberg, Britton C Goodale, Margaret Kurzius-Spencer, Andrew A Meharg, Mark D Miller, Anne E Nigra, Claire B PendergrastAndrea Raab, Ken Reimer, Kirk G Scheckel, Tanja Schwerdtle, Vivien F Taylor, Erik J Tokar, Todd M Warczak, Margaret R Karagas

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)


The diet is emerging as the dominant source of arsenic exposure for most of the U.S. population. Despite this, limited regulatory efforts have been aimed at mitigating exposure, and the role of diet in arsenic exposure and disease processes remains understudied. In this brief, we discuss the evidence linking dietary arsenic intake to human disease and discuss challenges associated with exposure characterization and efforts to quantify risks. In light of these challenges, and in recognition of the potential longer-term process of establishing regulation, we introduce a framework for shorter-term interventions that employs a field-to-plate food supply chain model to identify monitoring, intervention, and communication opportunities as part of a multisector, multiagency, science-informed, public health systems approach to mitigation of dietary arsenic exposure. Such an approach is dependent on coordination across commodity producers, the food industry, nongovernmental organizations, health professionals, researchers, and the regulatory community. https://doi.org/10.1289/EHP3997.

Original languageEnglish
Article number84503
Number of pages6
JournalEnvironmental Health Perspectives
Issue number8
Publication statusPublished - 31 Aug 2018

Bibliographical note

This paper, a product of the Collaborative on Food with Arsenic and associated Risk and Regulation (C-FARR), is supported by the Dartmouth College Toxic Metals Superfund Research Program through funds from the National Institute of Environmental Health Sciences (NIEHS) of the National Institutes of Health (NIH) under Award Number 1R13ES026493-01 to C. C. and Award Number P42ES007373 to Bruce Stanton, and the Children's Environmental Health and Disease Prevention Research Center at Dartmouth through funds from the NIEHS of the NIH under Award Number P01ES022832 and from the U.S. Environmental Protection Agency RD-83544201 to M. K. The views expressed in this paper are the those of the authors and do not necessarily reflect the official views of any agency of the United States or other government. We are grateful to A. Seyfferth for helpful discussions regarding silica and rice production.


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