Outcome of Multifetal Pregnancy Reduction in Women with a Dichorionic Triamniotic Triplet Pregnancy to a Singleton Pregnancy: A Retrospective Nationwide Cohort Study

L. Van De Mheen; S. M.P. Everwijn; M. C. Haak; G. T.R. Manten; H. A. Zondervan; M. F.C.M. Knapen; M. A.J. Engels; J. J.H.M. Erwich; A. B. Coumans; J. M.G. Van Vugt; C. M. Bilardo; M. G. Van Pampus; C. J.M. De Groot; B. W.J. Mol; E. Pajkrt

doi:10.1159/000441650

Outcome of Multifetal Pregnancy Reduction in Women with a Dichorionic Triamniotic Triplet Pregnancy to a Singleton Pregnancy: A Retrospective Nationwide Cohort Study

L. Van De Mheen, S. M.P. Everwijn, M. C. Haak, G. T.R. Manten, H. A. Zondervan, M. F.C.M. Knapen, M. A.J. Engels, J. J.H.M. Erwich, A. B. Coumans, J. M.G. Van Vugt, C. M. Bilardo, M. G. Van Pampus, C. J.M. De Groot, B. W.J. Mol, E. Pajkrt

Applied Health Sciences

Research output: Contribution to journal › Review article › peer-review

20 Citations (Scopus)

Abstract

Objective: To study the pregnancy outcomes of women with a dichorionic triamniotic triplet pregnancy that was reduced to a singleton pregnancy and to review the literature. Methods: We performed a nationwide retrospective cohort study. We compared time to delivery and perinatal mortality in dichorionic triplet pregnancies reduced to singletons with ongoing dichorionic triplet pregnancies and primary singleton pregnancies. Additionally, we reviewed the literature on the subject. Results: We studied 46 women with a reduced dichorionic triplet pregnancy and 42 women with an ongoing dichorionic triplet pregnancy. Median gestational age at delivery was 38.7 vs. 32.8 weeks, respectively (p < 0.001). Delivery <24 weeks occurred in 9 (19.6%) women with a reduced triplet pregnancy and 4 (9.5%) with an ongoing triplet pregnancy (p = 0.19). Perinatal survival rates between the reduced group and the ongoing triplet group were not significantly different. Conclusion: Multifetal pregnancy reduction in women with a dichorionic triplet pregnancy to a singleton pregnancy prolongs median gestational age at birth. No statistically significant association was found with miscarriage and perinatal survival rates.

Original language	English
Pages (from-to)	94-99
Number of pages	6
Journal	Fetal Diagnosis and Therapy
Volume	40
Issue number	2
DOIs	https://doi.org/10.1159/000441650
Publication status	Published - 1 Aug 2016

Keywords

Monochorionicity
Multifetal pregnancy reduction
Pregnancy outcome
Triplet pregnancy

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10.1159/000441650

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Van De Mheen, L., Everwijn, S. M. P., Haak, M. C., Manten, G. T. R., Zondervan, H. A., Knapen, M. F. C. M., Engels, M. A. J., Erwich, J. J. H. M., Coumans, A. B., Van Vugt, J. M. G., Bilardo, C. M., Van Pampus, M. G., De Groot, C. J. M., Mol, B. W. J., & Pajkrt, E. (2016). Outcome of Multifetal Pregnancy Reduction in Women with a Dichorionic Triamniotic Triplet Pregnancy to a Singleton Pregnancy: A Retrospective Nationwide Cohort Study. Fetal Diagnosis and Therapy, 40(2), 94-99. https://doi.org/10.1159/000441650

Outcome of Multifetal Pregnancy Reduction in Women with a Dichorionic Triamniotic Triplet Pregnancy to a Singleton Pregnancy: A Retrospective Nationwide Cohort Study. / Van De Mheen, L.; Everwijn, S. M.P.; Haak, M. C. et al.
In: Fetal Diagnosis and Therapy, Vol. 40, No. 2, 01.08.2016, p. 94-99.

Research output: Contribution to journal › Review article › peer-review

Van De Mheen, L, Everwijn, SMP, Haak, MC, Manten, GTR, Zondervan, HA, Knapen, MFCM, Engels, MAJ, Erwich, JJHM, Coumans, AB, Van Vugt, JMG, Bilardo, CM, Van Pampus, MG, De Groot, CJM, Mol, BWJ & Pajkrt, E 2016, 'Outcome of Multifetal Pregnancy Reduction in Women with a Dichorionic Triamniotic Triplet Pregnancy to a Singleton Pregnancy: A Retrospective Nationwide Cohort Study', Fetal Diagnosis and Therapy, vol. 40, no. 2, pp. 94-99. https://doi.org/10.1159/000441650

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title = "Outcome of Multifetal Pregnancy Reduction in Women with a Dichorionic Triamniotic Triplet Pregnancy to a Singleton Pregnancy: A Retrospective Nationwide Cohort Study",

abstract = "Objective: To study the pregnancy outcomes of women with a dichorionic triamniotic triplet pregnancy that was reduced to a singleton pregnancy and to review the literature. Methods: We performed a nationwide retrospective cohort study. We compared time to delivery and perinatal mortality in dichorionic triplet pregnancies reduced to singletons with ongoing dichorionic triplet pregnancies and primary singleton pregnancies. Additionally, we reviewed the literature on the subject. Results: We studied 46 women with a reduced dichorionic triplet pregnancy and 42 women with an ongoing dichorionic triplet pregnancy. Median gestational age at delivery was 38.7 vs. 32.8 weeks, respectively (p < 0.001). Delivery <24 weeks occurred in 9 (19.6%) women with a reduced triplet pregnancy and 4 (9.5%) with an ongoing triplet pregnancy (p = 0.19). Perinatal survival rates between the reduced group and the ongoing triplet group were not significantly different. Conclusion: Multifetal pregnancy reduction in women with a dichorionic triplet pregnancy to a singleton pregnancy prolongs median gestational age at birth. No statistically significant association was found with miscarriage and perinatal survival rates.",

keywords = "Monochorionicity, Multifetal pregnancy reduction, Pregnancy outcome, Triplet pregnancy",

author = "{Van De Mheen}, L. and Everwijn, {S. M.P.} and Haak, {M. C.} and Manten, {G. T.R.} and Zondervan, {H. A.} and Knapen, {M. F.C.M.} and Engels, {M. A.J.} and Erwich, {J. J.H.M.} and Coumans, {A. B.} and {Van Vugt}, {J. M.G.} and Bilardo, {C. M.} and {Van Pampus}, {M. G.} and {De Groot}, {C. J.M.} and Mol, {B. W.J.} and E. Pajkrt",

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T1 - Outcome of Multifetal Pregnancy Reduction in Women with a Dichorionic Triamniotic Triplet Pregnancy to a Singleton Pregnancy

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AU - Van De Mheen, L.

AU - Everwijn, S. M.P.

AU - Haak, M. C.

AU - Manten, G. T.R.

AU - Zondervan, H. A.

AU - Knapen, M. F.C.M.

AU - Engels, M. A.J.

AU - Erwich, J. J.H.M.

AU - Coumans, A. B.

AU - Van Vugt, J. M.G.

AU - Bilardo, C. M.

AU - Van Pampus, M. G.

AU - De Groot, C. J.M.

AU - Mol, B. W.J.

AU - Pajkrt, E.

PY - 2016/8/1

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N2 - Objective: To study the pregnancy outcomes of women with a dichorionic triamniotic triplet pregnancy that was reduced to a singleton pregnancy and to review the literature. Methods: We performed a nationwide retrospective cohort study. We compared time to delivery and perinatal mortality in dichorionic triplet pregnancies reduced to singletons with ongoing dichorionic triplet pregnancies and primary singleton pregnancies. Additionally, we reviewed the literature on the subject. Results: We studied 46 women with a reduced dichorionic triplet pregnancy and 42 women with an ongoing dichorionic triplet pregnancy. Median gestational age at delivery was 38.7 vs. 32.8 weeks, respectively (p < 0.001). Delivery <24 weeks occurred in 9 (19.6%) women with a reduced triplet pregnancy and 4 (9.5%) with an ongoing triplet pregnancy (p = 0.19). Perinatal survival rates between the reduced group and the ongoing triplet group were not significantly different. Conclusion: Multifetal pregnancy reduction in women with a dichorionic triplet pregnancy to a singleton pregnancy prolongs median gestational age at birth. No statistically significant association was found with miscarriage and perinatal survival rates.

AB - Objective: To study the pregnancy outcomes of women with a dichorionic triamniotic triplet pregnancy that was reduced to a singleton pregnancy and to review the literature. Methods: We performed a nationwide retrospective cohort study. We compared time to delivery and perinatal mortality in dichorionic triplet pregnancies reduced to singletons with ongoing dichorionic triplet pregnancies and primary singleton pregnancies. Additionally, we reviewed the literature on the subject. Results: We studied 46 women with a reduced dichorionic triplet pregnancy and 42 women with an ongoing dichorionic triplet pregnancy. Median gestational age at delivery was 38.7 vs. 32.8 weeks, respectively (p < 0.001). Delivery <24 weeks occurred in 9 (19.6%) women with a reduced triplet pregnancy and 4 (9.5%) with an ongoing triplet pregnancy (p = 0.19). Perinatal survival rates between the reduced group and the ongoing triplet group were not significantly different. Conclusion: Multifetal pregnancy reduction in women with a dichorionic triplet pregnancy to a singleton pregnancy prolongs median gestational age at birth. No statistically significant association was found with miscarriage and perinatal survival rates.

KW - Monochorionicity

KW - Multifetal pregnancy reduction

KW - Pregnancy outcome

KW - Triplet pregnancy

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Outcome of Multifetal Pregnancy Reduction in Women with a Dichorionic Triamniotic Triplet Pregnancy to a Singleton Pregnancy: A Retrospective Nationwide Cohort Study

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Keywords

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