Abstract
Pain remains a major unmet health need. Rising opioid prescribing has not reduced population pain and has directly contributed to increased morbidity and mortality. Opioid use disorder (OUD) and pain frequently coexist. Many people with OUD experience acute and chronic pain and a substantial proportion of patients prescribed opioids develop OUD. We have contributed to this problem. In this Position Paper, we defend the idea that we must urgently redefine pain medicine as a frontline discipline in opioid use disorder prevention and recovery. Pain management must be reframed as part of the solution for people with or at risk of OUD. Core principles include: early identification of OUD and psychiatric comorbidity, routine incorporation of trauma-informed, stigma-reducing communication and shared decision-making; continuation of opioid agonist therapy during acute care; use of tailored multimodal, opioid-sparing analgesia; and perioperative planning with addiction and primary care follow-up. At a system level, we recommend multidisciplinary opioid stewardship, clear limits on opioid indication, dose and duration, diversion-mitigation strategies and policy changes such as reduced pack sizes and limiting indications for prolonged-released opioids. Research priorities include qualitative studies of lived experience, inclusion of patient-reported outcomes in trials and big-data analyses of prescribing to identify targets for intervention. Integrating clinical best practice, stigma-aware care and system reforms can reduce harm while ensuring equitable, effective pain relief for people with pain and those with or at risk of OUD. SIGNIFICANCE: This position paper synthesises clinical, psychosocial and system-level strategies to manage pain in people with or at risk of OUD. It emphasises our unique responsibility by learning from failures, and constructively sees the future. Treatment continuity, trauma-informed and stigma-reducing communication, integrated care, interdisciplinary coordination and opioid stewardship policies are no longer optional. These recommendations aim to reduce harms, improve pain and mental-health outcomes and guide clinicians and policymakers toward better and more equitable care.
| Original language | English |
|---|---|
| Article number | e70263 |
| Number of pages | 5 |
| Journal | European Journal of Pain |
| Volume | 30 |
| Issue number | 4 |
| Early online date | 4 Apr 2026 |
| DOIs | |
| Publication status | Published - Apr 2026 |
Bibliographical note
Open Access via the Wiley agreementAI-powered application, namely Copilot (Microsoft, United States), was employed for linguistic processing objectives, encompassing grammar correction and the enhancement of word selection. The authors reviewed and edited the final version as needed and take full responsibility for the content of the publication.
All the authors conceptualised the work, wrote together the manuscript, reviewed, edited and approved the final version and have read and confirmed meeting the ICMJE criteria for authorship.
Funding
The authors have nothing to report.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- opioid use disorders
- opioids
- pain management
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