Palmitoylation Controls BK Channel Regulation By Phosphorylation

Lijun Tian; Owen Jeffries; Heather McClafferty; Adam Molyvdas; Iain Rowe; Fozia Saleem; Lie Chen; Michael J. Shipston

doi:10.1016/j.bpj.2008.12.2447

Palmitoylation Controls BK Channel Regulation By Phosphorylation

Lijun Tian, Owen Jeffries, Heather McClafferty, Adam Molyvdas, Iain Rowe, Fozia Saleem, Lie Chen, Michael J. Shipston

Medical Education

University of Edinburgh

Research output: Contribution to journal › Article › peer-review

Abstract

Large conductance calcium- and voltage- gated potassium (BK) channels are important regulators of physiological homeostasis and their function is potently modulated by protein kinase A (PKA) phosphorylation. PKA regulates the channel through phosphorylation of residues within the intracellular C-terminus of the pore-forming α-subunits. However, how PKA phosphorylation of the α-subunit effects changes in channel activity are unknown...

Original language	English
Pages (from-to)	473a
Journal	Biophysical Journal
Volume	4
Issue number	Supplement 1
DOIs	https://doi.org/10.1016/j.bpj.2008.12.2447
Publication status	Published - Feb 2009

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10.1016/j.bpj.2008.12.2447

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@article{963a06ad3a9549a8b97b6c8dfa76ff38,

title = "Palmitoylation Controls BK Channel Regulation By Phosphorylation",

abstract = "Large conductance calcium- and voltage- gated potassium (BK) channels are important regulators of physiological homeostasis and their function is potently modulated by protein kinase A (PKA) phosphorylation. PKA regulates the channel through phosphorylation of residues within the intracellular C-terminus of the pore-forming α-subunits. However, how PKA phosphorylation of the α-subunit effects changes in channel activity are unknown...",

author = "Lijun Tian and Owen Jeffries and Heather McClafferty and Adam Molyvdas and Iain Rowe and Fozia Saleem and Lie Chen and Shipston, {Michael J.}",

year = "2009",

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language = "English",

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journal = "Biophysical Journal",

issn = "0006-3495",

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T1 - Palmitoylation Controls BK Channel Regulation By Phosphorylation

AU - Tian, Lijun

AU - Jeffries, Owen

AU - McClafferty, Heather

AU - Molyvdas, Adam

AU - Rowe, Iain

AU - Saleem, Fozia

AU - Chen, Lie

AU - Shipston, Michael J.

PY - 2009/2

Y1 - 2009/2

N2 - Large conductance calcium- and voltage- gated potassium (BK) channels are important regulators of physiological homeostasis and their function is potently modulated by protein kinase A (PKA) phosphorylation. PKA regulates the channel through phosphorylation of residues within the intracellular C-terminus of the pore-forming α-subunits. However, how PKA phosphorylation of the α-subunit effects changes in channel activity are unknown...

AB - Large conductance calcium- and voltage- gated potassium (BK) channels are important regulators of physiological homeostasis and their function is potently modulated by protein kinase A (PKA) phosphorylation. PKA regulates the channel through phosphorylation of residues within the intracellular C-terminus of the pore-forming α-subunits. However, how PKA phosphorylation of the α-subunit effects changes in channel activity are unknown...

U2 - 10.1016/j.bpj.2008.12.2447

DO - 10.1016/j.bpj.2008.12.2447

M3 - Article

SN - 0006-3495

VL - 4

SP - 473a

JO - Biophysical Journal

JF - Biophysical Journal

IS - Supplement 1

ER -

Palmitoylation Controls BK Channel Regulation By Phosphorylation

Abstract

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