Partitioning the variance in calorie restriction-induced weight and fat loss in outbred mice

Lobke M Vaanholt; Jeffrey E Lane; Bethany Garner; John R Speakman

doi:10.1002/oby.21579

Partitioning the variance in calorie restriction-induced weight and fat loss in outbred mice

Lobke M Vaanholt
, Jeffrey E Lane
, Bethany Garner
, John R Speakman

University of Saskatchewan
University of Aberdeen

Research output: Contribution to journal › Article › peer-review

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Abstract

OBJECTIVE: An increased understanding of the factors influencing interindividual variation in calorie restriction (CR)-induced weight loss is necessary to combat the current obesity epidemic. This study investigated the partitioning of the phenotypic variation in CR-induced wight loss.

METHODS: Two generations of male and female outbred MF1 mice raised by their biological mother or a foster mother were studied. Mice were exposed to 4 weeks of 30% CR when 6 months old.

RESULTS: Heritability was estimated at 0.43 ± 0.12 for CR-induced changes in body mass and 0.24 ± 0.10 for fat mass using mid-parent-offspring regressions. No significant relationships between weight loss in fathers or foster mothers and offspring were observed. Partitioning of phenotypic variance in weight loss using maximum likelihood modeling indicated 19 ± 17% of the variation could be attributed to additive genetic effects, 8 ± 14% to maternal effects during pregnancy, and <1% to maternal effects during lactation. A narrow-sense heritability around 0.50 was observed for ad libitum food intake and general activity.

CONCLUSIONS: A large part of individual variation in CR-induced weight loss could be attributed to additive genetic and maternal effects during pregnancy, but not to maternal effects in lactation. Genetic differences in food intake and general activity may play a role in determining these effects.

Original language	English
Pages (from-to)	2111-2117
Number of pages	7
Journal	Obesity
Volume	24
Issue number	10
Early online date	16 Aug 2016
DOIs	https://doi.org/10.1002/oby.21579
Publication status	Published - Oct 2016

Bibliographical note

Funding agencies: LMV was funded by a Rubicon grant from the Netherlands Organisation for Scientific Research (NWO, 825.08.014). This work was supported by BBSRC grant BB/G009953/1.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

additive genetic effects
maternal effects
lactation

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Accepted Manuscript
This is the peer reviewed version of the following article: Vaanholt, L. M., Lane, J. E., Garner, B. and Speakman, J. R. (2016), Partitioning the variance in calorie restriction-induced weight and fat loss in outbred mice. Obesity, 24: 2111–2117., which has been published in final form at doi:10.1002/oby.21579. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Accepted author manuscript, 101 KBLicence: Unspecified

Cite this

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title = "Partitioning the variance in calorie restriction-induced weight and fat loss in outbred mice",

abstract = "OBJECTIVE: An increased understanding of the factors influencing interindividual variation in calorie restriction (CR)-induced weight loss is necessary to combat the current obesity epidemic. This study investigated the partitioning of the phenotypic variation in CR-induced wight loss.METHODS: Two generations of male and female outbred MF1 mice raised by their biological mother or a foster mother were studied. Mice were exposed to 4 weeks of 30\% CR when 6 months old.RESULTS: Heritability was estimated at 0.43 ± 0.12 for CR-induced changes in body mass and 0.24 ± 0.10 for fat mass using mid-parent-offspring regressions. No significant relationships between weight loss in fathers or foster mothers and offspring were observed. Partitioning of phenotypic variance in weight loss using maximum likelihood modeling indicated 19 ± 17\% of the variation could be attributed to additive genetic effects, 8 ± 14\% to maternal effects during pregnancy, and <1\% to maternal effects during lactation. A narrow-sense heritability around 0.50 was observed for ad libitum food intake and general activity.CONCLUSIONS: A large part of individual variation in CR-induced weight loss could be attributed to additive genetic and maternal effects during pregnancy, but not to maternal effects in lactation. Genetic differences in food intake and general activity may play a role in determining these effects.",

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author = "Vaanholt, \{Lobke M\} and Lane, \{Jeffrey E\} and Bethany Garner and Speakman, \{John R\}",

note = "Funding agencies: LMV was funded by a Rubicon grant from the Netherlands Organisation for Scientific Research (NWO, 825.08.014). This work was supported by BBSRC grant BB/G009953/1.",

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AU - Speakman, John R

N1 - Funding agencies: LMV was funded by a Rubicon grant from the Netherlands Organisation for Scientific Research (NWO, 825.08.014). This work was supported by BBSRC grant BB/G009953/1.

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N2 - OBJECTIVE: An increased understanding of the factors influencing interindividual variation in calorie restriction (CR)-induced weight loss is necessary to combat the current obesity epidemic. This study investigated the partitioning of the phenotypic variation in CR-induced wight loss.METHODS: Two generations of male and female outbred MF1 mice raised by their biological mother or a foster mother were studied. Mice were exposed to 4 weeks of 30% CR when 6 months old.RESULTS: Heritability was estimated at 0.43 ± 0.12 for CR-induced changes in body mass and 0.24 ± 0.10 for fat mass using mid-parent-offspring regressions. No significant relationships between weight loss in fathers or foster mothers and offspring were observed. Partitioning of phenotypic variance in weight loss using maximum likelihood modeling indicated 19 ± 17% of the variation could be attributed to additive genetic effects, 8 ± 14% to maternal effects during pregnancy, and <1% to maternal effects during lactation. A narrow-sense heritability around 0.50 was observed for ad libitum food intake and general activity.CONCLUSIONS: A large part of individual variation in CR-induced weight loss could be attributed to additive genetic and maternal effects during pregnancy, but not to maternal effects in lactation. Genetic differences in food intake and general activity may play a role in determining these effects.

AB - OBJECTIVE: An increased understanding of the factors influencing interindividual variation in calorie restriction (CR)-induced weight loss is necessary to combat the current obesity epidemic. This study investigated the partitioning of the phenotypic variation in CR-induced wight loss.METHODS: Two generations of male and female outbred MF1 mice raised by their biological mother or a foster mother were studied. Mice were exposed to 4 weeks of 30% CR when 6 months old.RESULTS: Heritability was estimated at 0.43 ± 0.12 for CR-induced changes in body mass and 0.24 ± 0.10 for fat mass using mid-parent-offspring regressions. No significant relationships between weight loss in fathers or foster mothers and offspring were observed. Partitioning of phenotypic variance in weight loss using maximum likelihood modeling indicated 19 ± 17% of the variation could be attributed to additive genetic effects, 8 ± 14% to maternal effects during pregnancy, and <1% to maternal effects during lactation. A narrow-sense heritability around 0.50 was observed for ad libitum food intake and general activity.CONCLUSIONS: A large part of individual variation in CR-induced weight loss could be attributed to additive genetic and maternal effects during pregnancy, but not to maternal effects in lactation. Genetic differences in food intake and general activity may play a role in determining these effects.

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KW - maternal effects

KW - lactation

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Partitioning the variance in calorie restriction-induced weight and fat loss in outbred mice

Abstract

Bibliographical note

UN SDGs

Keywords

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