Pharmacist-independent prescriber deprescribing in UK care homes: Contextual factors associated with increased activity

Mohammed Alharthi, Sion Scott* (Corresponding Author), David Phillip Alldred, Richard Holland, Carmel Hughes, Linda Birt, Jeanette Blacklock, Christine Bond, Allan Clark, David Wright

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Aims The Care Home Independent Pharmacist Prescriber Study (CHIPPS) process evaluation hypothesized that contextual factors influenced the likelihood of deprescribing by pharmacist-independent prescribers. The aim of this paper is to test this hypothesis. Methods From CHIPPS study data, medications deprescribed totalled 284 for 370 residents in UK care homes. Regression analysis was used to describe the relationship between the number of medicines stopped and contextual factors (number of residents cared for, pharmacist employment within associated medical practice, previous care home experience, hours active within trial, years? experience as a pharmacist and as a prescriber). Results Number of residents and pharmacist-independent prescriber employment within a medical practice were positive predictors of deprescribing. Conclusion Previous experiences were not related to deprescribing likelihood. Increasing the number of residents increases the opportunity for deprescribing and therefore this relationship is intuitive. The location within a medical practice is an interesting finding that requires further exploration to understand its exact nature.
Original languageEnglish
Pages (from-to)1509-1513
Number of pages5
JournalBritish Journal of Clinical Pharmacology
Issue number4
Early online date23 Dec 2022
Publication statusPublished - 1 Apr 2023

Bibliographical note

We would like to thank the residents, families, pharmacists, medical practice staff and care home staff who contributed to CHIPPS.

Funding information: This study is funded by the National Institute for Health Research (NIHR) for Health Research (NIHR) Translating Research into Policy funding scheme (Award ID: NIHR202053). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care.

Data Availability Statement

The analysed datasets used in the current study are available upon reasonable request from the corresponding author


  • deprescription
  • long-term care facilities
  • medication review
  • medicines optimization
  • nursing home
  • polypharmacy
  • residential home


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