Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation

Charlotte King; Amanda McKenna; Niloufar Farzan; Susanne J. Vijverberg; Marc P. van der Schee; Anke H. Maitland-van der Zee; Lambang Arianto; Hans Bisgaard; Klaus BØnnelykke; Vojko Berce; Uroš Potočnik; Katja Repnik; Bruce Carleton; Denise Daley; Fook Tim Chew; Wen Chin Chiang; Yang Yie Sio; Michelle M. Cloutier; Herman T. Den Dekker; Liesbeth Duijts; Johan C. de Jongste; F. Nicole Dijk; Gerard H. Koppelman; Carlos Flores; Natalia Hernandez-Pacheco; Maria Pino-Yanes; Somnath Mukhopadhyay; Kaninika Basu; Lauren Bignell; Kelan G. Tantisira; Steve Turner; Katia M. Verhamme; Ben Francis; Munir Pirmohamed; Ian Sinha; Daniel B. Hawcutt

doi:10.1038/s41397-019-0140-y

Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation

Charlotte King
, Amanda McKenna
, Niloufar Farzan
, Susanne J. Vijverberg
, Marc P. van der Schee
, Anke H. Maitland-van der Zee
, Lambang Arianto
, Hans Bisgaard
, Klaus BØnnelykke
, Vojko Berce
, Uroš Potočnik
, Katja Repnik
, Bruce Carleton
, Denise Daley
, Fook Tim Chew
, Wen Chin Chiang
, Yang Yie Sio
, Michelle M. Cloutier
, Herman T. Den Dekker
, Liesbeth Duijts

Johan C. de Jongste, F. Nicole Dijk, Gerard H. Koppelman, Carlos Flores, Natalia Hernandez-Pacheco, Maria Pino-Yanes, Somnath Mukhopadhyay, Kaninika Basu, Lauren Bignell, Kelan G. Tantisira, Steve Turner, Katia M. Verhamme, Ben Francis, Munir Pirmohamed, Ian Sinha, Daniel B. Hawcutt^* (Corresponding Author)

^*Corresponding author for this work

University of Amsterdam
University Medical Centre Maribor
University of Maribor
University of British Columbia
National University of Singapore
KK Children’s Hospital
University of Connecticut
Erasmus University Rotterdam
University of Groningen
Hospital Universitario Nuestra Senora de Candelaria
Brighton and Sussex Medical School
Harvard University
Alder Hey Children's NHS Foundation Trust
University of Liverpool
University of Copenhagen

Research output: Contribution to journal › Review article › peer-review

10 Citations (Scopus)

11 Downloads (Pure)

Abstract

A systematic review of pharmacogenomic studies capturing adverse drug reactions (ADRs) related to asthma medications was undertaken, and a survey of Pharmacogenomics in Childhood Asthma (PiCA) consortia members was conducted. Studies were eligible if genetic polymorphisms were compared with suspected ADR(s) in a patient with asthma, as either a primary or secondary outcome. Five studies met the inclusion criteria. The ADRs and polymorphisms identified were change in lung function tests (rs1042713), adrenal suppression (rs591118), and decreased bone mineral density (rs6461639) and accretion (rs9896933, rs2074439). Two of these polymorphisms were replicated within the paper, but none had external replication. Priorities from PiCA consortia members (representing 15 institution in eight countries) for future studies were tachycardia (SABA/LABA), adrenal suppression/crisis and growth suppression (corticosteroids), sleep/behaviour disturbances (leukotriene receptor antagonists), and nausea and vomiting (theophylline). Future pharmacogenomic studies in asthma should collect relevant ADR data as well as markers of efficacy.

Original language	English
Pages (from-to)	621-628
Number of pages	8
Journal	Pharmacogenomics Journal
Volume	20
Early online date	17 Jan 2020
DOIs	https://doi.org/10.1038/s41397-019-0140-y
Publication status	Published - Oct 2020

Bibliographical note

We would like to thank the NIHR Collaboration for Leadership in Applied Health Research and Care North West Coast (CLAHRC) for funding Amanda McKenna’s internship, and Charlotte Kings MPhil, and the members of the PiCA consortia for their help in completing the survey. U. Potočnik, K. Repnik and V. Berce were supported by SysPharmPedia grant, co-financed by Ministry of Education, Science and Sport of the Republic of Slovenia

Author information
These authors contributed equally: Charlotte King, Amanda McKenna
These authors jointly supervised this work: Ian Sinha, Daniel B. Hawcutt

Funding

Acknowledgements We would like to thank the NIHR Collaboration for Leadership in Applied Health Research and Care North West Coast (CLAHRC) for funding Amanda McKenna’s internship, and Charlotte Kings MPhil, and the members of the PiCA consortia for their help in completing the survey. U. Potočnik, K. Repnik and V. Berce were supported by SysPharmPedia grant, co-financed by Ministry of Education, Science and Sport of the Republic of Slovenia

Keywords

CHILDREN
EXACERBATIONS
RISK
POLYMORPHISM
BURDEN

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King, C., McKenna, A., Farzan, N., Vijverberg, S. J., van der Schee, M. P., Maitland-van der Zee, A. H., Arianto, L., Bisgaard, H., BØnnelykke, K., Berce, V., Potočnik, U., Repnik, K., Carleton, B., Daley, D., Chew, F. T., Chiang, W. C., Sio, Y. Y., Cloutier, M. M., Den Dekker, H. T., ... Hawcutt, D. B. (2020). Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation. Pharmacogenomics Journal, 20, 621-628. https://doi.org/10.1038/s41397-019-0140-y

King, C, McKenna, A, Farzan, N, Vijverberg, SJ, van der Schee, MP, Maitland-van der Zee, AH, Arianto, L, Bisgaard, H, BØnnelykke, K, Berce, V, Potočnik, U, Repnik, K, Carleton, B, Daley, D, Chew, FT, Chiang, WC, Sio, YY, Cloutier, MM, Den Dekker, HT, Duijts, L, de Jongste, JC, Dijk, FN, Koppelman, GH, Flores, C, Hernandez-Pacheco, N, Pino-Yanes, M, Mukhopadhyay, S, Basu, K, Bignell, L, Tantisira, KG, Turner, S, Verhamme, KM, Francis, B, Pirmohamed, M, Sinha, I & Hawcutt, DB 2020, 'Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation', Pharmacogenomics Journal, vol. 20, pp. 621-628. https://doi.org/10.1038/s41397-019-0140-y

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abstract = "A systematic review of pharmacogenomic studies capturing adverse drug reactions (ADRs) related to asthma medications was undertaken, and a survey of Pharmacogenomics in Childhood Asthma (PiCA) consortia members was conducted. Studies were eligible if genetic polymorphisms were compared with suspected ADR(s) in a patient with asthma, as either a primary or secondary outcome. Five studies met the inclusion criteria. The ADRs and polymorphisms identified were change in lung function tests (rs1042713), adrenal suppression (rs591118), and decreased bone mineral density (rs6461639) and accretion (rs9896933, rs2074439). Two of these polymorphisms were replicated within the paper, but none had external replication. Priorities from PiCA consortia members (representing 15 institution in eight countries) for future studies were tachycardia (SABA/LABA), adrenal suppression/crisis and growth suppression (corticosteroids), sleep/behaviour disturbances (leukotriene receptor antagonists), and nausea and vomiting (theophylline). Future pharmacogenomic studies in asthma should collect relevant ADR data as well as markers of efficacy.",

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N2 - A systematic review of pharmacogenomic studies capturing adverse drug reactions (ADRs) related to asthma medications was undertaken, and a survey of Pharmacogenomics in Childhood Asthma (PiCA) consortia members was conducted. Studies were eligible if genetic polymorphisms were compared with suspected ADR(s) in a patient with asthma, as either a primary or secondary outcome. Five studies met the inclusion criteria. The ADRs and polymorphisms identified were change in lung function tests (rs1042713), adrenal suppression (rs591118), and decreased bone mineral density (rs6461639) and accretion (rs9896933, rs2074439). Two of these polymorphisms were replicated within the paper, but none had external replication. Priorities from PiCA consortia members (representing 15 institution in eight countries) for future studies were tachycardia (SABA/LABA), adrenal suppression/crisis and growth suppression (corticosteroids), sleep/behaviour disturbances (leukotriene receptor antagonists), and nausea and vomiting (theophylline). Future pharmacogenomic studies in asthma should collect relevant ADR data as well as markers of efficacy.

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Pharmacogenomic associations of adverse drug reactions in asthma: systematic review and research prioritisation

Abstract

Bibliographical note

Funding

Keywords

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