Possible mechanism of action of transfusion effect in renal-transplantation

Alison Murray MacLeod; R. J.  Mason; W. G.  Shewan; D. A.  Power; Keith Nicol Stewart; N.  Edward; G. R. D.  Catto

doi:10.1016/S0140-6736(82)90496-2

Possible mechanism of action of transfusion effect in renal-transplantation

Alison Murray MacLeod, R. J. Mason, W. G. Shewan, D. A. Power, Keith Nicol Stewart, N. Edward, G. R. D. Catto

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Abstract

The mechanism by which blood transfusions given before renal transplantation improves allograft survival was studied in 31 transplant recipients. The presence of non-cytotoxic, Fc receptor blocking antibodies to donor and leukaemic B lymphocytes in pre-transplant sera correlated with both improved graft survival (p<0 ·03 and <0·1, respectively) and the number of blood transfusions given (p<0 ·05 and <0 ·03, respectively). Moreover, 6 out of 10 previously untransfused prospective transplant recipients developed these potentially protective antibodies during a course of elective blood transfusions. These results indicate that such non-cytotoxic, Fc receptor blocking antibodies in pretransplant recipient sera (a) are associated with improved allograft survival, (b) correlate with the number of blood transfusions given, and (c) can develop in response to blood transfusion.

Original language	English
Pages (from-to)	468-470
Number of pages	3
Journal	The Lancet
Volume	2
Issue number	8296
DOIs	https://doi.org/10.1016/S0140-6736(82)90496-2
Publication status	Published - 28 Aug 1982

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title = "Possible mechanism of action of transfusion effect in renal-transplantation",

abstract = "The mechanism by which blood transfusions given before renal transplantation improves allograft survival was studied in 31 transplant recipients. The presence of non-cytotoxic, Fc receptor blocking antibodies to donor and leukaemic B lymphocytes in pre-transplant sera correlated with both improved graft survival (p<0 ·03 and <0·1, respectively) and the number of blood transfusions given (p<0 ·05 and <0 ·03, respectively). Moreover, 6 out of 10 previously untransfused prospective transplant recipients developed these potentially protective antibodies during a course of elective blood transfusions. These results indicate that such non-cytotoxic, Fc receptor blocking antibodies in pretransplant recipient sera (a) are associated with improved allograft survival, (b) correlate with the number of blood transfusions given, and (c) can develop in response to blood transfusion. ",

author = "MacLeod, {Alison Murray} and Mason, {R. J.} and Shewan, {W. G.} and Power, {D. A.} and Stewart, {Keith Nicol} and N. Edward and Catto, {G. R. D.}",

year = "1982",

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T1 - Possible mechanism of action of transfusion effect in renal-transplantation

AU - MacLeod, Alison Murray

AU - Mason, R. J.

AU - Shewan, W. G.

AU - Power, D. A.

AU - Stewart, Keith Nicol

AU - Edward, N.

AU - Catto, G. R. D.

PY - 1982/8/28

Y1 - 1982/8/28

N2 - The mechanism by which blood transfusions given before renal transplantation improves allograft survival was studied in 31 transplant recipients. The presence of non-cytotoxic, Fc receptor blocking antibodies to donor and leukaemic B lymphocytes in pre-transplant sera correlated with both improved graft survival (p<0 ·03 and <0·1, respectively) and the number of blood transfusions given (p<0 ·05 and <0 ·03, respectively). Moreover, 6 out of 10 previously untransfused prospective transplant recipients developed these potentially protective antibodies during a course of elective blood transfusions. These results indicate that such non-cytotoxic, Fc receptor blocking antibodies in pretransplant recipient sera (a) are associated with improved allograft survival, (b) correlate with the number of blood transfusions given, and (c) can develop in response to blood transfusion.

AB - The mechanism by which blood transfusions given before renal transplantation improves allograft survival was studied in 31 transplant recipients. The presence of non-cytotoxic, Fc receptor blocking antibodies to donor and leukaemic B lymphocytes in pre-transplant sera correlated with both improved graft survival (p<0 ·03 and <0·1, respectively) and the number of blood transfusions given (p<0 ·05 and <0 ·03, respectively). Moreover, 6 out of 10 previously untransfused prospective transplant recipients developed these potentially protective antibodies during a course of elective blood transfusions. These results indicate that such non-cytotoxic, Fc receptor blocking antibodies in pretransplant recipient sera (a) are associated with improved allograft survival, (b) correlate with the number of blood transfusions given, and (c) can develop in response to blood transfusion.

U2 - 10.1016/S0140-6736(82)90496-2

DO - 10.1016/S0140-6736(82)90496-2

M3 - Article

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VL - 2

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EP - 470

JO - The Lancet

JF - The Lancet

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ER -

Possible mechanism of action of transfusion effect in renal-transplantation

Abstract

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