Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors: Data from the EuroSpA collaboration

Lykke M. Ørnbjerg, Louise Linde* (Corresponding Author), Stylianos Georgiadis, Simon H. Rasmussen, Ulf Lindström, Johan Askling, Brigitte Michelsen, Daniela Di Giuseppe, Johan K. Wallman, Karel Pavelka, Jakub Závada, Michael J. Nissen, Gareth T. Jones, Heikki Relas, Laura Pirilä, Matija Tomšič, Ziga Rotar, Arni Jon Geirsson, Bjorn Gudbjornsson, Eirik K. KristianslundIrene van sder Horst-Bruinsma, Anne Gitte Loft, Karin Laas, Florenzo Iannone, Addolorata Corrado, Adrian Ciurea, Maria J. Santos, Helena Santos, Catalin Codreanu, Nurullah Akkoc, Ozgul S. Gunduz, Bente Glintborg, Mikkel Østergaard, Merete Lund Hetland

*Corresponding author for this work

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Abstract

Objectives: In patients with axial spondyloarthritis (axSpA) initiating their first tumor necrosis factor alpha-inhibitor (TNFi), we aimed to identify common baseline predictors of Ankylosing Spondylitis Disease Activity Score (ASDAS-CRP) inactive disease (primary objective) and clinically important improvement (CII) at 6 months, and drug retention at 12-months across 15 European registries. Methods: Baseline demographic and clinical characteristics were collected. Outcomes were investigated per registry and in pooled data using logistic regression analyses on multiply imputed data. Results: The consistency of baseline predictors in individual registries justified pooling the data. In the pooled dataset (n = 21,196), the 6-month rates for ASDAS inactive disease and ASDAS CII were 26% and 51%, and the 12-month drug retention rate 65% in patients with available data (n = 9,845, n = 6,948 and n = 21,196, respectively). Nine common baseline predictors of ASDAS inactive disease, ASDAS CII and 12-month drug retention were identified, and the odds ratios (95%-confidence interval) for ASDAS inactive disease were: age, per year: 0.97 (0.97–0.98), men vs. women: 1.88 (1.60–2.22), current vs. non-smoking: 0.76 (0.63–0.91), HLA-B27 positive vs. negative: 1.51 (1.20–1.91), TNF start year 2015–2018 vs. 2009–2014: 1.24 (1.06–1.45), CRP>10 vs. ≤10 mg/l: 1.49 (1.25–1.77), one unit increase in health assessment questionnaire (HAQ): 0.77 (0.58–1.03), one-millimeter (mm) increase in Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) fatigue and spinal pain: 0.99 (0.99–1.00) and 0.99 (0.99–1.99), respectively Conclusion: Common baseline predictors of treatment response and adherence to TNFi could be identified across data from 15 European registries, indicating that they may be universal across different axSpA populations.

Original languageEnglish
Article number152081
Number of pages13
JournalSeminars in arthritis and rheumatism
Volume56
Early online date17 Aug 2022
DOIs
Publication statusPublished - 1 Oct 2022

Bibliographical note

Funding Information
This work was supported by Novartis Pharma AG .

Acknowledgments
The EuroSpA Research Collaboration Network was financially supported by Novartis Pharma AG. Novartis had no influence on the data collection, statistical analyses, manuscript preparation or decision to submit the manuscript. Professor Gary Macfarlane (University of Aberdeen) is Chief Investigator of BSRBR-AS and facilitated access to the UK data used in this study.

Corrigendum to ‘Predictors of ASDAS-CRP inactive disease in axial spondyloarthritis during treatment with TNF-inhibitors: data from the EuroSpA collaboration’ [Seminars in Arthritis and Rheumatism 56 (2022) 1-13/152081]
https://doi.org/10.1016/j.semarthrit.2022.152141

Data Availability Statement

The data in this article was collected in the individual registries and made available for secondary use through the EuroSpA Research Collaboration Network [https://eurospa.eu/#registries] Relevant patient level data may be made available on reasonable request to the corresponding author, but will require approval from all contributing registries.

Supplementary material associated with this article can be found, in the online version, at doi:10.1016/j.semarthrit.2022.152081.

Keywords

  • Ankylosing spondylitis disease activity score
  • Axial spondyloarthritis
  • Predictors
  • TNF-inhibitors

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