Progress and challenges in analyzing rodent energy expenditure

Rodrigo Fernández-Verdejo, Eric Ravussin, John R Speakman, Jose E Galgani*

*Corresponding author for this work

Research output: Contribution to journalComment/debatepeer-review

28 Citations (Scopus)


Whole-body energy expenditure is the summed metabolic activities of tissues and, to remove the influence of body size, ratios of energy expenditure to body mass are often applied but can generate spurious differences. In 2011, a group of experts proposed adoption of ANCOVA for the analysis of metabolic rate but, seven years later, analyses based on ratios remain the most frequent. We discuss some of the barriers to adopting better analytical procedures.
Original languageEnglish
Pages (from-to)797-799
Number of pages3
JournalNature methods
Early online date7 Aug 2019
Publication statusPublished - Sept 2019

Bibliographical note

R.F.V. was supported by Fondecyt #11180361 (Conicyt, Chile). J.E.G was supported by Fondecyt #1170117 (Conicyt, Chile).




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