Progress and challenges in analyzing rodent energy expenditure

Rodrigo Fernández-Verdejo; Eric Ravussin; John R Speakman; Jose E Galgani

doi:10.1038/s41592-019-0513-9

Progress and challenges in analyzing rodent energy expenditure

Rodrigo Fernández-Verdejo, Eric Ravussin, John R Speakman, Jose E Galgani^*

^*Corresponding author for this work

Research output: Contribution to journal › Comment/debate › peer-review

28 Citations (Scopus)

Abstract

Whole-body energy expenditure is the summed metabolic activities of tissues and, to remove the influence of body size, ratios of energy expenditure to body mass are often applied but can generate spurious differences. In 2011, a group of experts proposed adoption of ANCOVA for the analysis of metabolic rate but, seven years later, analyses based on ratios remain the most frequent. We discuss some of the barriers to adopting better analytical procedures.

Original language	English
Pages (from-to)	797-799
Number of pages	3
Journal	Nature methods
Volume	16
Early online date	7 Aug 2019
DOIs	https://doi.org/10.1038/s41592-019-0513-9
Publication status	Published - Sept 2019

Bibliographical note

R.F.V. was supported by Fondecyt #11180361 (Conicyt, Chile). J.E.G was supported by Fondecyt #1170117 (Conicyt, Chile).

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AU - Ravussin, Eric

AU - Speakman, John R

AU - Galgani, Jose E

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N2 - Whole-body energy expenditure is the summed metabolic activities of tissues and, to remove the influence of body size, ratios of energy expenditure to body mass are often applied but can generate spurious differences. In 2011, a group of experts proposed adoption of ANCOVA for the analysis of metabolic rate but, seven years later, analyses based on ratios remain the most frequent. We discuss some of the barriers to adopting better analytical procedures.

AB - Whole-body energy expenditure is the summed metabolic activities of tissues and, to remove the influence of body size, ratios of energy expenditure to body mass are often applied but can generate spurious differences. In 2011, a group of experts proposed adoption of ANCOVA for the analysis of metabolic rate but, seven years later, analyses based on ratios remain the most frequent. We discuss some of the barriers to adopting better analytical procedures.

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Progress and challenges in analyzing rodent energy expenditure

Abstract

Bibliographical note

Keywords

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