Abstract
The central dogma describes the unidirectional flow of genetic information from DNA to proteins, leading to an underappreciation of the potential for the information contained in proteomes (the full set of proteins in an organism) to reflect broader biological processes such as lifespan. Here, this is addressed by examining how the size and composition of 276 proteomes from four vertebrate classes are related to lifespan. After accounting for the relationship between body weight and lifespan, lifespan is negatively correlated with proteome size in birds and, to a weaker extent, in fish, and positively correlated with lifespan in mammals. Proteome composition varies amongst the four vertebrate classes, but there is no evidence that any specific amino acid correlated with lifespan. The findings in relation to the role of dietary amino acid restriction are discussed on lifespan extension and raise questions about evolutionary and structural forces shaping proteome composition across species.
| Original language | English |
|---|---|
| Article number | 2400633 |
| Number of pages | 6 |
| Journal | Advanced Biology |
| Volume | 9 |
| Issue number | 4 |
| Early online date | 17 Feb 2025 |
| DOIs | |
| Publication status | Published - Apr 2025 |
Bibliographical note
Open access via the Wiley AgreementData Availability Statement
Data and code are available in GitHub:https://github.com/jmor2753/advbiol_2025_proteome.
Supporting Information is available from the Wiley Online Library or from the author.
Funding
JM is supported by the Biotechnology and Biological Sciences Research Council [BBSRC: BB/V015249/1].
| Funders | Funder number |
|---|---|
| Biotechnology and Biological Sciences Research Council | BB/V015249/1 |
Keywords
- comparative genetics
- dietary restriction
- trade-offs
- comparative genomics
- Animals
- Proteomics
- Birds/physiology
- Longevity/physiology
- Mammals/physiology
- Proteome/metabolism