Rationale and Design of SCOT-HEART 2 Trial: CT Angiography for the Prevention of Myocardial Infarction

Michael McDermott; Mohammed N. Meah; Phyo Khaing; Kang Ling Wang; Jennifer Ramsay; Gillian Scott; Hannah Rickman; Tom Burt; Ian McGowan; Timothy Fairbairn; Marise Bucukoglu; Russell Bull; Adam Timmis; Edwin J.R. van Beek; Giles Roditi; Philip D. Adamson; Steff Lewis; John Norrie; Brian McKinstry; Bruce Guthrie; Lewis Ritchie; Nicholas L. Mills; Marc R. Dweck; Michelle C. Williams; David E. Newby

doi:10.1016/j.jcmg.2024.05.016

Rationale and Design of SCOT-HEART 2 Trial: CT Angiography for the Prevention of Myocardial Infarction

Michael McDermott^*, Mohammed N. Meah, Phyo Khaing, Kang Ling Wang, Jennifer Ramsay, Gillian Scott, Hannah Rickman, Tom Burt, Ian McGowan, Timothy Fairbairn, Marise Bucukoglu, Russell Bull, Adam Timmis, Edwin J.R. van Beek, Giles Roditi, Philip D. Adamson, Steff Lewis, John Norrie, Brian McKinstry, Bruce GuthrieLewis Ritchie, Nicholas L. Mills, Marc R. Dweck, Michelle C. Williams, David E. Newby^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

3 Citations (Scopus)

Abstract

Coronary artery disease continues to be the leading cause of death globally. Identifying patients who are at risk of coronary artery disease remains a public health priority. At present, the focus of cardiovascular disease prevention relies heavily on probabilistic risk scoring despite no randomized controlled trials demonstrating their efficacy. The concept of using imaging to guide preventative therapy is not new, but has previously focused on indirect measures such as carotid intima-media thickening or coronary artery calcification. In recent trials, patients found to have coronary artery disease on computed tomography (CT) coronary angiography were more likely to be started on preventative therapy and had lower rates of cardiac events. This led to the design of the SCOT-HEART 2 (Scottish Computed Tomography of the Heart 2) trial, which aims to determine whether screening with the use of CT coronary angiography is more clinically effective than cardiovascular risk scoring to guide the use of primary preventative therapies and reduce the risk of myocardial infarction.

Original language	English
Number of pages	12
Journal	JACC: Cardiovascular Imaging
Early online date	10 Jul 2024
DOIs	https://doi.org/10.1016/j.jcmg.2024.05.016
Publication status	E-pub ahead of print - 10 Jul 2024

Keywords

CT coronary angiography
risk-scoring

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jcmg.2024.05.016Licence: CC BY

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McDermott, M., Meah, M. N., Khaing, P., Wang, K. L., Ramsay, J., Scott, G., Rickman, H., Burt, T., McGowan, I., Fairbairn, T., Bucukoglu, M., Bull, R., Timmis, A., van Beek, E. J. R., Roditi, G., Adamson, P. D., Lewis, S., Norrie, J., McKinstry, B., ... Newby, D. E. (2024). Rationale and Design of SCOT-HEART 2 Trial: CT Angiography for the Prevention of Myocardial Infarction. JACC: Cardiovascular Imaging. Advance online publication. https://doi.org/10.1016/j.jcmg.2024.05.016

McDermott, M, Meah, MN, Khaing, P, Wang, KL, Ramsay, J, Scott, G, Rickman, H, Burt, T, McGowan, I, Fairbairn, T, Bucukoglu, M, Bull, R, Timmis, A, van Beek, EJR, Roditi, G, Adamson, PD, Lewis, S, Norrie, J, McKinstry, B, Guthrie, B, Ritchie, L, Mills, NL, Dweck, MR, Williams, MC & Newby, DE 2024, 'Rationale and Design of SCOT-HEART 2 Trial: CT Angiography for the Prevention of Myocardial Infarction', JACC: Cardiovascular Imaging. https://doi.org/10.1016/j.jcmg.2024.05.016

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abstract = "Coronary artery disease continues to be the leading cause of death globally. Identifying patients who are at risk of coronary artery disease remains a public health priority. At present, the focus of cardiovascular disease prevention relies heavily on probabilistic risk scoring despite no randomized controlled trials demonstrating their efficacy. The concept of using imaging to guide preventative therapy is not new, but has previously focused on indirect measures such as carotid intima-media thickening or coronary artery calcification. In recent trials, patients found to have coronary artery disease on computed tomography (CT) coronary angiography were more likely to be started on preventative therapy and had lower rates of cardiac events. This led to the design of the SCOT-HEART 2 (Scottish Computed Tomography of the Heart 2) trial, which aims to determine whether screening with the use of CT coronary angiography is more clinically effective than cardiovascular risk scoring to guide the use of primary preventative therapies and reduce the risk of myocardial infarction.",

keywords = "CT coronary angiography, risk-scoring",

author = "Michael McDermott and Meah, {Mohammed N.} and Phyo Khaing and Wang, {Kang Ling} and Jennifer Ramsay and Gillian Scott and Hannah Rickman and Tom Burt and Ian McGowan and Timothy Fairbairn and Marise Bucukoglu and Russell Bull and Adam Timmis and {van Beek}, {Edwin J.R.} and Giles Roditi and Adamson, {Philip D.} and Steff Lewis and John Norrie and Brian McKinstry and Bruce Guthrie and Lewis Ritchie and Mills, {Nicholas L.} and Dweck, {Marc R.} and Williams, {Michelle C.} and Newby, {David E.}",

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doi = "10.1016/j.jcmg.2024.05.016",

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T2 - CT Angiography for the Prevention of Myocardial Infarction

AU - McDermott, Michael

AU - Meah, Mohammed N.

AU - Khaing, Phyo

AU - Wang, Kang Ling

AU - Ramsay, Jennifer

AU - Scott, Gillian

AU - Rickman, Hannah

AU - Burt, Tom

AU - McGowan, Ian

AU - Fairbairn, Timothy

AU - Bucukoglu, Marise

AU - Bull, Russell

AU - Timmis, Adam

AU - van Beek, Edwin J.R.

AU - Roditi, Giles

AU - Adamson, Philip D.

AU - Lewis, Steff

AU - Norrie, John

AU - McKinstry, Brian

AU - Guthrie, Bruce

AU - Ritchie, Lewis

AU - Mills, Nicholas L.

AU - Dweck, Marc R.

AU - Williams, Michelle C.

AU - Newby, David E.

PY - 2024/7/10

Y1 - 2024/7/10

N2 - Coronary artery disease continues to be the leading cause of death globally. Identifying patients who are at risk of coronary artery disease remains a public health priority. At present, the focus of cardiovascular disease prevention relies heavily on probabilistic risk scoring despite no randomized controlled trials demonstrating their efficacy. The concept of using imaging to guide preventative therapy is not new, but has previously focused on indirect measures such as carotid intima-media thickening or coronary artery calcification. In recent trials, patients found to have coronary artery disease on computed tomography (CT) coronary angiography were more likely to be started on preventative therapy and had lower rates of cardiac events. This led to the design of the SCOT-HEART 2 (Scottish Computed Tomography of the Heart 2) trial, which aims to determine whether screening with the use of CT coronary angiography is more clinically effective than cardiovascular risk scoring to guide the use of primary preventative therapies and reduce the risk of myocardial infarction.

AB - Coronary artery disease continues to be the leading cause of death globally. Identifying patients who are at risk of coronary artery disease remains a public health priority. At present, the focus of cardiovascular disease prevention relies heavily on probabilistic risk scoring despite no randomized controlled trials demonstrating their efficacy. The concept of using imaging to guide preventative therapy is not new, but has previously focused on indirect measures such as carotid intima-media thickening or coronary artery calcification. In recent trials, patients found to have coronary artery disease on computed tomography (CT) coronary angiography were more likely to be started on preventative therapy and had lower rates of cardiac events. This led to the design of the SCOT-HEART 2 (Scottish Computed Tomography of the Heart 2) trial, which aims to determine whether screening with the use of CT coronary angiography is more clinically effective than cardiovascular risk scoring to guide the use of primary preventative therapies and reduce the risk of myocardial infarction.

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KW - risk-scoring

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U2 - 10.1016/j.jcmg.2024.05.016

DO - 10.1016/j.jcmg.2024.05.016

M3 - Review article

C2 - 39001735

AN - SCOPUS:85199439072

SN - 1936-878X

JO - JACC: Cardiovascular Imaging

JF - JACC: Cardiovascular Imaging

ER -

Rationale and Design of SCOT-HEART 2 Trial: CT Angiography for the Prevention of Myocardial Infarction

Abstract

Keywords

UN SDGs

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