Rationale and Design of SCOT-HEART 2 Trial: CT Angiography for the Prevention of Myocardial Infarction

Michael McDermott; Mohammed N. Meah; Phyo Khaing; Kang Ling Wang; Jennifer Ramsay; Gillian Scott; Hannah Rickman; Tom Burt; Ian McGowan; Timothy Fairbairn; Marise Bucukoglu; Russell Bull; Adam Timmis; Edwin J.R. van Beek; Giles Roditi; Philip D. Adamson; Steff Lewis; John Norrie; Brian McKinstry; Bruce Guthrie; Lewis Ritchie; Nicholas L. Mills; Marc R. Dweck; Michelle C. Williams; David E. Newby

doi:10.1016/j.jcmg.2024.05.016

Rationale and Design of SCOT-HEART 2 Trial: CT Angiography for the Prevention of Myocardial Infarction

Michael McDermott^*
, Mohammed N. Meah
, Phyo Khaing
, Kang Ling Wang
, Jennifer Ramsay
, Gillian Scott
, Hannah Rickman
, Tom Burt
, Ian McGowan
, Timothy Fairbairn
, Marise Bucukoglu
, Russell Bull
, Adam Timmis
, Edwin J.R. van Beek
, Giles Roditi
, Philip D. Adamson
, Steff Lewis
, John Norrie
, Brian McKinstry
, Bruce Guthrie

Lewis Ritchie, Nicholas L. Mills, Marc R. Dweck, Michelle C. Williams, David E. Newby^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

27 Citations (Scopus)

Abstract

Coronary artery disease continues to be the leading cause of death globally. Identifying patients who are at risk of coronary artery disease remains a public health priority. At present, the focus of cardiovascular disease prevention relies heavily on probabilistic risk scoring despite no randomized controlled trials demonstrating their efficacy. The concept of using imaging to guide preventative therapy is not new, but has previously focused on indirect measures such as carotid intima-media thickening or coronary artery calcification. In recent trials, patients found to have coronary artery disease on computed tomography (CT) coronary angiography were more likely to be started on preventative therapy and had lower rates of cardiac events. This led to the design of the SCOT-HEART 2 (Scottish Computed Tomography of the Heart 2) trial, which aims to determine whether screening with the use of CT coronary angiography is more clinically effective than cardiovascular risk scoring to guide the use of primary preventative therapies and reduce the risk of myocardial infarction.

Original language	English
Pages (from-to)	1101-1112
Number of pages	12
Journal	JACC: Cardiovascular Imaging
Volume	17
Issue number	9
Early online date	3 Sept 2024
DOIs	https://doi.org/10.1016/j.jcmg.2024.05.016
Publication status	Published - Sept 2024

Funding

Dr McDermott is supported by a British Heart Foundation Clinical Research Training Fellowship (FS/CRTF/23/24491). Drs Mills and Newby are supported by a Chair Award, Programme Grant, and Research Excellence Award (CH/F/21/90010, CH/09/002/26360, RG/20/10/34966, RG/F/22/110093, RE/24/130012) from the British Heart Foundation. The SCOT-HEART 2 trial is funded by the British Heart Foundation (CS/18/4/34074). Dr Williams is supported by the British Heart Foundation (FS/ICRF/20/26002); and has given talks for Canon Medical Systems, Siemens Healthineers, and Novartis. Dr Mills has received research grants, honoraria, or consultancy fees from Abbott Diagnostics, Roche Diagnostics, Siemens Healthineers, LumiraDx, and Pyros Laboratories. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Funders	Funder number
British Heart Foundation	FS/CRTF/23/24491, CH/F/21/90010, CH/09/002/26360, RG/20/10/34966, RG/F/22/110093, RE/24/130012, CS/18/4/34074, FS/ICRF/20/26002

Keywords

CT coronary angiography
risk-scoring

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

McDermott, M., Meah, M. N., Khaing, P., Wang, K. L., Ramsay, J., Scott, G., Rickman, H., Burt, T., McGowan, I., Fairbairn, T., Bucukoglu, M., Bull, R., Timmis, A., van Beek, E. J. R., Roditi, G., Adamson, P. D., Lewis, S., Norrie, J., McKinstry, B., ... Newby, D. E. (2024). Rationale and Design of SCOT-HEART 2 Trial: CT Angiography for the Prevention of Myocardial Infarction. JACC: Cardiovascular Imaging, 17(9), 1101-1112. https://doi.org/10.1016/j.jcmg.2024.05.016

McDermott, M, Meah, MN, Khaing, P, Wang, KL, Ramsay, J, Scott, G, Rickman, H, Burt, T, McGowan, I, Fairbairn, T, Bucukoglu, M, Bull, R, Timmis, A, van Beek, EJR, Roditi, G, Adamson, PD, Lewis, S, Norrie, J, McKinstry, B, Guthrie, B, Ritchie, L, Mills, NL, Dweck, MR, Williams, MC & Newby, DE 2024, 'Rationale and Design of SCOT-HEART 2 Trial: CT Angiography for the Prevention of Myocardial Infarction', JACC: Cardiovascular Imaging, vol. 17, no. 9, pp. 1101-1112. https://doi.org/10.1016/j.jcmg.2024.05.016

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abstract = "Coronary artery disease continues to be the leading cause of death globally. Identifying patients who are at risk of coronary artery disease remains a public health priority. At present, the focus of cardiovascular disease prevention relies heavily on probabilistic risk scoring despite no randomized controlled trials demonstrating their efficacy. The concept of using imaging to guide preventative therapy is not new, but has previously focused on indirect measures such as carotid intima-media thickening or coronary artery calcification. In recent trials, patients found to have coronary artery disease on computed tomography (CT) coronary angiography were more likely to be started on preventative therapy and had lower rates of cardiac events. This led to the design of the SCOT-HEART 2 (Scottish Computed Tomography of the Heart 2) trial, which aims to determine whether screening with the use of CT coronary angiography is more clinically effective than cardiovascular risk scoring to guide the use of primary preventative therapies and reduce the risk of myocardial infarction.",

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Rationale and Design of SCOT-HEART 2 Trial: CT Angiography for the Prevention of Myocardial Infarction

Abstract

Funding

Keywords

UN SDGs

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