Recognition and diagnosis of invasive fungal infections in neonates

Joanne L Calley, Adilia Warris

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Fungal infections largely caused by Candida species are responsible for a significant disease burden in neonates and invasive candidiasis in hospitalised neonates has high associated morbidity and mortality. Early initiation of antifungal treatment improves outcome but the recognition and diagnosis of systemic fungal infection in this population is difficult due to the non-specific clinical presentation and the high false negative rate of cultures. There is a need for a practical, sensitive and rapid diagnostic test to enhance identification and early treatment. Serum detection of (1,3)-β-d-glucan and Candida PCR are promising candidates but at present limited data exists for their use in the neonatal intensive care setting. Until such investigations are validated, early initiation of antifungal treatment on the basis of risk factor profile and clinical features remains the safest practical approach.

Original languageEnglish
Pages (from-to)S108-S113
Number of pages6
JournalJournal of Infection
Issue numberSuppl 1
Early online date23 Jun 2017
Publication statusPublished - Jun 2017

Bibliographical note

This work has been supported by the MRC and the University of Aberdeen (MRC Centre for Medical Mycology) and by the Wellcome Trust Strategic Award − Medical Mycology Fungal Immunology.


  • Candidiasis
  • Premature neonate
  • Low birth weight infants
  • Risk factors
  • Biomarkers


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