Ribosomally synthesized and post-translationally modified peptide natural products: Overview and recommendations for a universal nomenclature

Paul G. Arnison, Mervyn J. Bibb, Gabriele Bierbaum, Albert A. Bowers, Tim S. Bugni, Grzegorz Bulaj, Julio A. Camarero, Dominic J. Campopiano, Gregory L. Challis, Jon Clardy, Paul D. Cotter, David J. Craik, Michael Dawson, Elke Dittmann, Stefano Donadio, Pieter C. Dorrestein, Karl-Dieter Entian, Michael A. Fischbach, John S. Garavelli, Ulf GöranssonChristian W. Gruber, Daniel H. Haft, Thomas K. Hemscheidt, Christian Hertweck, Colin Hill, Alexander R. Horswill, Marcel Jaspars, Wendy L. Kelly, Judith P. Klinman, Oscar P. Kuipers, A. James Link, Wen Liu, Mohamed A. Marahiel, Douglas A. Mitchell, Gert N. Moll, Bradley S. Moore, Rolf Müller, Satish K. Nair, Ingolf F. Nes, Gillian E. Norris, Baldomero M. Olivera, Hiroyasu Onaka, Mark L. Patchett, Joern Piel, Martin J. T. Reaney, Sylvie Rebuffat, R. Paul Ross, Hans-Georg Sahl, Eric W. Schmidt, Michael E. Selsted, Konstantin Severinov, Ben Shen, Kaarina Sivonen, Leif Smith, Torsten Stein, Roderich D. Süssmuth, John R. Tagg, Gong-Li Tang, Andrew W. Truman, John C. Vederas, Christopher T. Walsh, Jonathan D. Walton, Silke C. Wenzel, Joanne M. Willey, Wilfred A. van der Donk

Research output: Contribution to journalArticlepeer-review

1392 Citations (Scopus)


Covering: 1988 to 2012

This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products. The current knowledge regarding the biosynthesis of the >20 distinct compound classes is also reviewed, and commonalities are discussed.

Original languageEnglish
Pages (from-to)108-160
Number of pages53
JournalNatural Product Reports
Issue number1
Early online date19 Nov 2012
Publication statusPublished - Jan 2013

Bibliographical note

The recommendations in this review were compiled from the answers to two sets of successive questionnaires. Several discussion groups then made recommendations to the entire group of authors. The discussion groups were led by David Craik (cyclotides), Elke Dittmann (microviridins), Baldomero Olivera (conopeptides), Sylvie Rebuffat (microcins), Eric Schmidt (cyanobactins and LAPs), Wilfred van der Donk (lanthipeptides and glycocins), John Vederas (sactipeptides and N-to-C cyclized peptides), and Christopher Walsh (thiopeptides). The final write-ups for the several classes of compounds were provided by David Craik (cyclotides), Elke Dittmann (microviridins), Wendy Kelly (thiopeptides), Douglas Mitchell (LAPs), Joern Piel (proteusins), Baldomero Olivera (conopeptides), Martin Reaney (orbitides), Sylvie Rebuffat (microcins and lasso peptides), Eric Schmidt (cyanobactins), Wilfred van der Donk (introduction, lanthipeptides, linaridins, bottromycins, glycocins, quorum sensing peptides, PQQ, methanobactin, linear nomenclature, and outlook) and John Vederas (sactipeptides, N-to-C cyclized peptides, linear nomenclature). Coordination of the discussions and assembly and editing of the final review was done by Wilfred van der Donk. We thank Dr Qi Zhang (UIUC) for help with illustrations.


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