Risk factors for Barrett's oesophagus and oesophageal adenocarcinoma: Results from the FINBAR study

Lesley A. Anderson*, R. G.Peter Watson, Seamus J. Murphy, Brian T. Johnston, Harry Comber, Jim McGuigan, John V. Reynolds, Liam J. Murray

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

220 Citations (Scopus)


Aim: To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma. Methods: This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients, 227 oesophageal adenocarcinoma patients and 260 controls. All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors. Results: Gastro-oesophageal reflux was associated with Barrett's [OR 12.0 (95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48 (95% CI 2.25-5.41)]. Oesophageal adenocarcinoma patients were more likely than controls to be ex- or current smokers [OR 1.72 (95% CI 1.06-2.81) and OR 4.84 (95% CI 2.72-8.61) respectively] and to have a high body mass index [OR 2.69 (95% CI 1.62-4.46)]. No significant associations were observed between these risk factors and Barrett's oesophagus. Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50 (95% CI 0.30-0.86)]. Conclusion: A high body mass index, a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma.

Original languageEnglish
Pages (from-to)1585-1594
Number of pages10
JournalWorld Journal of Gastroenterology
Issue number10
Publication statusPublished - 14 Mar 2007


  • Barrett's oesophagus
  • Body mass index
  • Case-control
  • Diet
  • Gastro-oesophageal reflux
  • Oesophageal adenocarcinoma
  • Smoking


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