Role of Pullulan in preparation of ceria nanoparticles and investigation of their biological activities

Mohammad Bagher Khorrami, Hamid Reza Sadeghnia, Alireza Pasdar, Majid Ghayour-Mobarhan, Bamdad Riahi-Zanjani, Majid Darroudi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


Throughout this work, a facile, environmental–friendly, and “green” method is delineated for preparing ceria nanoparticles (CNPs), which utilizes nontoxic and renewable degraded polysaccharide polymer including pullulan as a natural matrix. Pullulan behaves as a suitable stabilizing (capping) agent for CNPs that are effectively formed at various high temperatures, while they are structurally analyzed through different techniques such as TGA/DTG, XRD, FESEM, and FTIR instruments. This procedure was found to be comparable to the ones that were acquired from conventional preparation methods that employ hazardous materials, which confirms this approach to be an exquisite alternative in preparing CNPs through the benefit of bioorganic materials. The in vitro cytotoxicity studies on Neuro2A cells have mentioned nontoxic particles in a range of concentrations (0.97–125 μg/ml) and thus, we reckon that the prepared particular CNPs will have persistent utilization in various fields of biology and medicine.

Original languageEnglish
Pages (from-to)127-131
Number of pages5
JournalJournal of Molecular Structure
Early online date20 Dec 2017
Publication statusPublished - 5 Apr 2018

Bibliographical note

M. Darroudi thankfully acknowledge for technical and financial support for this project provided by Mashhad University of Medical Sciences (Grant # 930954) based on the PhD thesis of Mr. M.B. Khorrami.


  • Ceria (CeO)
  • Cytotoxicity
  • Electron microscopy
  • Nanoparticles
  • Pullulan


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