Screening of the central nervous system in children with invasive pulmonary aspergillosis

Emmi Broenen; Annelies Mavinkurve-Groothuis; Karin Kamphuis-van Ulzen; Roger Brüggemann; Paul Verweij; Adilia Warris

doi:10.1016/j.mmcr.2014.02.001

Screening of the central nervous system in children with invasive pulmonary aspergillosis

Emmi Broenen, Annelies Mavinkurve-Groothuis, Karin Kamphuis-van Ulzen, Roger Brüggemann, Paul Verweij, Adilia Warris

Radboud University Nijmegen

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

6 Downloads (Pure)

Abstract

The existing guidelines regarding the management of invasive pulmonary aspergillosis do not recommend screening of the extra-pulmonary sites. Due to the fact that the presence of central nervous system (CNS) aspergillosis will influence treatment decisions regarding which antifungal to use and the aimed target concentrations of azoles in plasma, to be informed about dissemination of the infection to the CNS is absolutely necessary. We demonstrate the need for a structured approach to screening of pediatric patients for CNS aspergillosis.

Original language	English
Pages (from-to)	8-11
Number of pages	4
Journal	Medical mycology case reports
Volume	4
Early online date	20 Feb 2014
DOIs	https://doi.org/10.1016/j.mmcr.2014.02.001
Publication status	Published - Apr 2014

Keywords

Aspergillosis
Central nervous system
Pediatrics
Screening
Therapeutic drug monitoring
Voriconazole

Access to Document

10.1016/j.mmcr.2014.02.001Licence: CC BY-NC-SA

Screening of the central nervous system in children with invasive pulmonary aspergillosis
© 2014 The Authors. International Society for Human and Animal Mycology. Published by Elsevier B.V. Open access under CC BY-NC-SA license. https://creativecommons.org/licenses/by-nc-sa/3.0/
Final published version, 438 KBLicence: CC BY-NC-SA

Cite this

@article{9a4dc032de6c4c899523247dd983fbad,

title = "Screening of the central nervous system in children with invasive pulmonary aspergillosis",

abstract = "The existing guidelines regarding the management of invasive pulmonary aspergillosis do not recommend screening of the extra-pulmonary sites. Due to the fact that the presence of central nervous system (CNS) aspergillosis will influence treatment decisions regarding which antifungal to use and the aimed target concentrations of azoles in plasma, to be informed about dissemination of the infection to the CNS is absolutely necessary. We demonstrate the need for a structured approach to screening of pediatric patients for CNS aspergillosis.",

keywords = "Aspergillosis, Central nervous system, Pediatrics, Screening, Therapeutic drug monitoring, Voriconazole",

author = "Emmi Broenen and Annelies Mavinkurve-Groothuis and {Kamphuis-van Ulzen}, Karin and Roger Br{\"u}ggemann and Paul Verweij and Adilia Warris",

year = "2014",

month = apr,

doi = "10.1016/j.mmcr.2014.02.001",

language = "English",

volume = "4",

pages = "8--11",

journal = "Medical mycology case reports",

issn = "2211-7539",

publisher = "Elsevier BV",

}

TY - JOUR

T1 - Screening of the central nervous system in children with invasive pulmonary aspergillosis

AU - Broenen, Emmi

AU - Mavinkurve-Groothuis, Annelies

AU - Kamphuis-van Ulzen, Karin

AU - Brüggemann, Roger

AU - Verweij, Paul

AU - Warris, Adilia

PY - 2014/4

Y1 - 2014/4

N2 - The existing guidelines regarding the management of invasive pulmonary aspergillosis do not recommend screening of the extra-pulmonary sites. Due to the fact that the presence of central nervous system (CNS) aspergillosis will influence treatment decisions regarding which antifungal to use and the aimed target concentrations of azoles in plasma, to be informed about dissemination of the infection to the CNS is absolutely necessary. We demonstrate the need for a structured approach to screening of pediatric patients for CNS aspergillosis.

AB - The existing guidelines regarding the management of invasive pulmonary aspergillosis do not recommend screening of the extra-pulmonary sites. Due to the fact that the presence of central nervous system (CNS) aspergillosis will influence treatment decisions regarding which antifungal to use and the aimed target concentrations of azoles in plasma, to be informed about dissemination of the infection to the CNS is absolutely necessary. We demonstrate the need for a structured approach to screening of pediatric patients for CNS aspergillosis.

KW - Aspergillosis

KW - Central nervous system

KW - Pediatrics

KW - Screening

KW - Therapeutic drug monitoring

KW - Voriconazole

U2 - 10.1016/j.mmcr.2014.02.001

DO - 10.1016/j.mmcr.2014.02.001

M3 - Article

C2 - 24624324

SN - 2211-7539

VL - 4

SP - 8

EP - 11

JO - Medical mycology case reports

JF - Medical mycology case reports

ER -

Screening of the central nervous system in children with invasive pulmonary aspergillosis

Abstract

Keywords

Access to Document

Fingerprint

Cite this