Selective AMPA Receptor Modulators

Iain Greig; Fang Liu; Dongxu Zhai; Zheng Cao

Selective AMPA Receptor Modulators

Iain Greig (Inventor)
, Fang Liu (Inventor)
, Dongxu Zhai (Inventor)
, Zheng Cao (Inventor)

Campbell Family Mental Health Research Institute, Toronto

Research output: Patent

Abstract

Provided are compounds of Formula (I) and related compositions and methods, including methods of therapy for treating neurological diseases and disorders, including multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS), and methods for in vivo imaging of AMPA receptor, or surrogate thereof, in the brain.

Original language	English
Patent number	WO2025068990
IPC	A61K31/506,A61K51/04,A61P25/16,A61P25/28,C07D487/04
Priority date	29/09/23
Filing date	27/09/24
Publication status	Published - 3 Apr 2025

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title = "Selective AMPA Receptor Modulators",

abstract = "Provided are compounds of Formula (I) and related compositions and methods, including methods of therapy for treating neurological diseases and disorders, including multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS), and methods for in vivo imaging of AMPA receptor, or surrogate thereof, in the brain.",

author = "Iain Greig and Fang Liu and Dongxu Zhai and Zheng Cao",

year = "2025",

month = apr,

day = "3",

language = "English",

publisher = "World Intellectual Property Organization",

type = "Patent",

note = "WO2025068990; A61K31/506,A61K51/04,A61P25/16,A61P25/28,C07D487/04",

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TY - PAT

T1 - Selective AMPA Receptor Modulators

AU - Greig, Iain

AU - Liu, Fang

AU - Zhai, Dongxu

AU - Cao, Zheng

PY - 2025/4/3

Y1 - 2025/4/3

N2 - Provided are compounds of Formula (I) and related compositions and methods, including methods of therapy for treating neurological diseases and disorders, including multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS), and methods for in vivo imaging of AMPA receptor, or surrogate thereof, in the brain.

AB - Provided are compounds of Formula (I) and related compositions and methods, including methods of therapy for treating neurological diseases and disorders, including multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS), and methods for in vivo imaging of AMPA receptor, or surrogate thereof, in the brain.

M3 - Patent

M1 - WO2025068990

Y2 - 2024/09/27

PB - World Intellectual Property Organization

ER -

Selective AMPA Receptor Modulators

Abstract

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